Hepatoprotective effects of Chinese herbal medicine Schisandra Chinensis (Schisandra) have been widely investigated. However, most studies were focused on its lignan extracts. We investigated the polysaccharide (SCP) in a mouse model non-alcoholic fatty liver disease (NAFLD), and studied effect sterol regulatory element binding proteins (SREBPs) related genes.The NAFLD was established by feeding mice with high-fat diet for 16 weeks. Effect SCP-treatment (100 mg/kg, once daily 12 weeks)...

Cortex Dictamni is a commonly-used traditional Chinese herbal medicine for the treatment of skin inflammation, tinea, and eczema. Recently, some studies reported that might induce liver injury, suggesting more attention to its safety. The current study was designed investigate subchronic toxicity aqueous extract (CDAE) ethanol (CDEE) in mice potential hepatotoxicity mechanisms vitro. Firstly, CDAE or CDEE groups were administrated with varying dosages (2.3, 4.6, 9.2 g/kg/day, p.o.) 28 days...

Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are treatment to relieve it. Polysacharides Citrus grandis L. Osbeck (PCG) luteolin have been reported activities. In this study, protective effects PCG on chronic evaluated underlying mechanisms explored. administrated animal models with granuloma, ear edema disease severity evaluated. We also evaluate inflammatory cytokine production in macrophages stimulated...

Abstract Background Norovirus (NoV) is a major cause of viral acute gastroenteritis (AGE) in children worldwide. Epidemiological analysis with respect to the virus strains limited China. This study aimed investigate prevalence, patterns, and molecular characteristics NoV infection among AGE Methods A total 4848 stool samples were collected from who admitted Tianjin Children’s Hospital August 2018 July 2020. was preliminarily detected using real-time reverse transcription polymerase chain...

Parkinson's disease (PD) is one of the most common nervous system degenerative diseases. However, etiology this remains elusive. Here, a proteasome inhibitor (PSI)-induced undifferentiated SH-SY5Y PD model was established to analyze protein alterations through proteomic study.Cultured cells were divided into control group and treated with 2.5 µM PSI (PSI-treated group). An methyl thiazolyl tetrazolium (MTT) assay applied detect cell viability. Acridine orange/ethidium bromide (AO/EB),...

This paper presents an effective optimization method using the Kriging surrogate model combing with modified rectangular grid sampling to reduce stent dogboning effect in expansion process. An infilling criterion named expected improvement (EI) is used balance local and global searches iteration. Four commonly finite element models of dilation were investigate rate. Thrombosis three typical shapes are built test effectiveness results. Numerical results show that two dilated by pressure...

As a main method of structure-based virtual screening, molecular docking is the most widely used in practice. However, non-ideal efficacy scoring functions thought as biggest barrier which hinders improvement method.A new multi-objective strategy for docking, named MoDock, presented to further improve accuracy with available functions. Instead simple combination multiple objectives fixed weight factors, an aggregate function adopted approximate real solution original and multi-constraint...

Purpose: This study aimed to investigate the species distributions and drug sensitivities among 19 strains of Nocardia isolated from Yantai, China, 2017 2019. Patients methods: Definitive identification was performed by sequencing a fragment 16S rRNA gene (1480 bp) matrix-assisted laser desorption/ionization-time flight mass spectrometry (MALDI-TOF MS). The susceptibilities isolates 15 commonly-used antibiotics were tested using microbroth dilution method. Results: Among isolates, five...

To investigate the epidemiological features of Klebsiella pneumoniae infection hepatobiliary system patients in Yantai, China.This retrospective study was conducted from January to December 2019 Yantai Yuhuangding Hospital. Patients for whom K. isolated were considered inclusion. The clinical and genetic analyses explore characteristics.A total 88 cases enrolled, including 69 hypervirulent (hvKP) 19 classical (cKP). Community-acquired infections, fever, liver abscess, C-reactive protein...

Norovirus (NoV) is the leading cause of acute gastroenteritis (AGE) worldwide. Globally, GII.4 Sydney 2012 strain has predominated since 2012, although variant strains have caused AGE outbreaks in China. Recent patterns NoV genotype distributions 6011 children with Tianjin, China were investigated. was detected using real-time reverse-transcriptase polymerase chain reaction and sequencing partial sequences viral capsid gene. genotypes determined, phylogenetic analysis conducted....

Objective: This study aims to analyze the prevalence of hypertension and 10-year cardiovascular disease (CVD) risk among older adults living in a coastal region southeast China. Methods: A population-based cross-sectional survey 2018 was conducted on 60– 98-year-old residents Quanzhou from September 2016 March using multistage stratified cluster random sampling. The CVD estimated by applying Chinese model recommended guidelines for prevention. Results: overall hypertension, prehypertension,...

Although intestinal microbiota play crucial roles in fish digestion and health, little is known about fungi fish. This study investigated the fungal diversity of three coral reef (Lates calcarifer, Trachinotus blochii, Lutjanus argentimaculatus) from South China Sea using a culturable method. A total 387 isolates were recovered identified by sequencing their internal transcribed spacer sequences, belonging to 29 species. The similarity communities intestines verified that colonization might...

The drug release analysis and optimization for drug‐eluting stents in the arterial wall are studied, which involves mechanics, fluid dynamics, mass transfer processes design optimization. Finite Element Method (FEM) is used to analyze process of vessels (DES). Kriging surrogate model build an approximate function relationship between distribution coating parameters, replacing expensive FEM reanalysis DES process. diffusion coefficients thickness selected as variables. An adaptive approach...

Cefoperazone/sulbactam (CSL) and piperacillin/tazobactam (TZP) are commonly used in clinical practice China because of their excellent antimicrobial activity. CSL TZP-nonsusceptible Enterobacteriaceae typically resistant to extended-spectrum cephalosporins such as ceftriaxone (CRO). However, 11 nonrepetitive strains, which were TZP yet susceptible CRO, collected from January December 2020. Antibiotic susceptibility tests whole-genome sequencing conducted elucidate the mechanism for this rare...

Abstract This study aims to investigate the characteristics of heat transfer and its mechanism for styling a design garment differently, improve thermal comfort caused by clothing design, computational fluid dynamics (CFD) approach has been used perform numerical investigations flow across air gap. Relationships between from body (computed equations) gap were examined loss different styles garments. Also, temperature distribution garments was obtained compared. Computed results reveal that...