A5100773835- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Autoimmune Neurological Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Genetics and Neurodevelopmental Disorders
- Ginkgo biloba and Cashew Applications
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Psoriasis: Treatment and Pathogenesis
Institute of Biophysics
2022-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2017-2025
Jiangsu Academy of Agricultural Sciences
2024-2025
Peking University
2008-2024
Peking University Cancer Hospital
1998-2024
First Hospital of Jilin University
2015-2024
Jilin University
2015-2024
Binzhou University
2024
Binzhou Medical University
2024
Mycoplasma hyorhinis infection has been postulated to play a role in the development of several types cancer, but direct evidence and mechanism remained be determined. Immunohistochemistry assay nested polymerase-chain reaction (PCR) were performed examine mycoplasma gastric cancer tissues. Statistical analysis was used check association between clinicopathologic parameters. Transwell chamber metastasis evaluate hyorhinis' effects on vitro vivo. hyorhinis-induced extracellular...
Objective This study is aimed at examining the potential roles of circulating memory T follicular helper (Tfh) cells in patients with multiple sclerosis (MS). Methods The numbers different subsets Tfh 25 relapsed MS before and after treatment as well 14 healthy controls (HC) were examined by flow cytometry. levels plasma IL-21 all cerebrospinal fluid (CSF) some non-inflammatory neuronal diseases (NND) measured ELISA. Results In comparison that HC, CD3+CD4+CXCR5+CD45RA-, ICOS+, CCR7+...
This paper applies a linear Bayesian regression model to study the effects of economic policy uncertainty (EPU) and Chief Executive Officer (CEO) characteristics on firm Research Development (R&D) expenditure. We specifically analysed data from 1,163 Chinese companies listed as A-shares 2008–2016. EPU is believed curtail investments it causes unexpected market conditions. Yet, our findings obtained with analysis show positive relationship between R&D Specifically, we found that some CEO...
Common wheat is a leading global food crop that impacts security. Wheat powdery mildew (PM), caused by Blumeria graminis f. sp. tritici (Bgt), poses significant threat to grain yield and flour quality. The identification utilization of broad-spectrum resistance genes against PM are essential for effective disease control. spectrum test during the seedling stage adult were conducted evaluate landrace Honghuamai (HHM). Five segregating populations investigated assess inheritance in HHM. To map...
Isocyanic acid, as a reactive metabolite synthesized by the enzyme LACC1, can carbamoylate ε-amino group of lysine residues in proteins. However, role isocyanic acid inflammatory response remains elusive. Herein, we reveal that lipopolysaccharide stimulation increases LACC1-dependent production, which attenuates inflammation limiting NLRP3 inflammasome activation macrophages primed with for 8 hours. Mechanistically, directly carbamoylates at lysine-593 to disrupt NLRP3-NEK7 interaction, key...
N-α-Acetyltransferase 10 protein (Naa10p, also called arrest-defective 1), the catalytic subunit of N-acetyltransferase A, is a critical regulator cell death and proliferation. Naa10p shown to regulate cancer metastasis by inhibiting motility; however, its role in not fully understood. In this study, we found that high expression positively correlated with survival patients breast cancer, whereas negatively lymph node metastasis. inhibits migration invasion vitro decreases xenograft growth...
Abstract Excessive consumption of fructose in the Western diet contributes to cancer development. However, it is still unclear how cells coordinate glucose and metabolism during tumor malignant progression. We demonstrate here that glioblastoma multiforme (GBM) switch their energy supply from glycolysis fructolysis response deprivation. Mechanistically, deprivation induces expression two essential fructolytic proteins GLUT5 ALDOB through selectively activating translation transcription...
Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely matched nonneoplastic adjacent tissues. In this study, we investigated the prognostic potential of SNCG colon particularly patients with normal carcinoembryonic antigen (CEA) levels.SNCG levels were assessed immunohistochemically tissues from 229 adenocarcinoma mean follow-up 44 months. Correlations between and clinicopathologic features,...
Background: Blood-brain barrier (BBB) pathology exists in neuromyelitis optica spectrum disorders (NMOSD). However, the clinical use of BBB permeability, such as predicting disease severity NMOSD, has rarely been studied a large cohort patients. Objectives: The current study explored association between permeability and parameters order to assess if could be biomarker predict characteristics NMOSD. Methods: Among 69 enrolled NMOSD patients, 47 with albumin index over 5 × 10-3 were assigned...
Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In present study, for first time we established cancerous line OSCC-BD induced B(a)P/DMBA mixture transformed from dysplastic DOK. Cell morphology, proliferation ability, migration colony formation, tumorigenicity were studied confirmed malignant characteristics cells. We further...
// Caiyun Liu 1, 2, * , Bingbing Shi 3, Chonghua Hao 4, Qinghai Wang 5, Qiang Lv 6, Nianzeng Xing 7, Jianzhong Shou 8, Like Qu 2 Yanning Gao 9 Chao Qin 6 Jiyu Zhao 7 Chengchao 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry Education) Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China Department Biochemistry 3 Urology, Union Medical College Hospital, Chinese Academy Sciences College, 4 Clinical Laboratory, Shanxi Provincial...