A5020975601- interferon and immune responses
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Fungal and yeast genetics research
- Plant biochemistry and biosynthesis
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Pancreatic function and diabetes
- RNA regulation and disease
- Plant Reproductive Biology
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Multiple Sclerosis Research Studies
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Glycogen Storage Diseases and Myoclonus
Zhengzhou Central Hospital
2024
China Agricultural University
2024
Tianjin Medical University
2024
Tianjin University
2023-2024
Hunan University
2024
Baylor College of Medicine
2022-2023
Zhengzhou University
2021-2023
First Affiliated Hospital of Zhengzhou University
2021-2023
Kiel University
2006-2023
Sun Yat-sen University
2016-2022
In addition to investigating the virology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovering host-virus dependencies are essential identify and design effective antiviral therapy strategy. Here, we report that SARS-CoV-2 entry receptor, ACE2, conjugates with small ubiquitin-like modifier 3 (SUMO3) provide evidence indicating prevention ACE2 SUMOylation can block infection. E3 SUMO ligase PIAS4 prompts stabilization whereas deSUMOylation enzyme SENP3 reverses this...
Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and an independent risk factor for cognitive impairment. However, it remains unclear how OSA linked to In the present study, we found correlation between morphological changes of perivascular spaces (PVSs) impairment in patients. Moreover, developed a novel set dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods evaluate fluid dynamics glymphatic drainage system. We that inflow outflow parameters...
Abstract The adaptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular mechanisms controlling its activity and stability are unclear. Here we show that NLRP11, primate specific gene, inhibits TLR signalling by targeting for degradation. NLRP11 recruits ubiquitin ligase RNF19A to catalyze K48-linked ubiquitination of at multiple sites, thereby leading degradation TRAF6. Furthermore, deficiency either or abrogates TRAF6, which promotes activation...
The inflammasome plays a critical role in inflammation and immune responses against pathogens. However, whether or how activation regulates type I interferon (IFN-I) signaling the context of malaria infection remain unknown. Here we show mice deficient sensors AIM2, NLRP3 adaptor Caspase-1 produce high levels IFN-I cytokines are resistant to lethal Plasmodium yoelii YM infection. Inactivation reduces interleukin (IL)-1β production, but increases production. Mechanistically, inflammsome...
Lung cancer is one of the most common causes related deaths worldwide. The role several microRNAs (miRNAs) including miR-196b in different cancers has already been established. study was aimed to explore lung and its possible underlying mechanism.Human cell line A549 transfected with mimic, inhibitor corresponding controls. Then viability, migration, invasion, apoptosis cells either overexpression or suppression were estimated sequentially. Next, dual luciferase activity assay performed...
Melanoma differentiation-associated gene-5 (MDA5) recognizes distinct subsets of viruses including Encephalomyocarditis virus (EMCV) picornavirus family, but the molecular mechanisms underlying specificity viral recognition MDA5 in immune cells remain obscure. DHX29 is an RNA helicase required for translation 5' structured mRNA host and many picornaviruses (such as EMCV). We identify that DXH29 a key co-sensor, plays significant role specific triggering anti-EMCV immunity. have observed...
Studies implicate that gut dysbiosis is related with many neurological diseases. However, the potential role of in cryptogenic stroke (CS) has not been elucidated yet. In this study, a high prevalence gastrointestinal (GI) dysfunction and inflammation increased intestinal permeability have found CS patients compared normal controls (NCs). The systemic was also identified by measuring levels plasma C-reactive protein (CRP), lipopolysaccharide (LPS), LPS-binding (LBP), white blood cells (WBC)...
Abstract Transactive response DNA-binding protein 43 kDa (TDP-43) has been identified as the major component of ubiquitinated inclusions found in patients with sporadic amyotrophic lateral sclerosis (ALS). Increasing evidence suggests prion-like transmission TDP-43 aggregates via neuroanatomic connection vitro and pyramidal tract vivo. However, it is still unknown whether spreading pathological sequentially can initiate ALS-like pathology phenotypes. In this study, we reported that injection...
In murine models of Crohn's disease, rheumatoid arthritis and colon cancer, IL-6 (interleukin-6) signalling via the sIL-6R (soluble receptor; termed trans-signalling) has been shown to promote pathology associated with these conditions. These detrimental activities can, however, be selectively blocked by soluble forms gp130 (glycoprotein 130) receptor. Although sgp130 gp130) therefore represents a viable therapeutic modality for treatment conditions, mass manufacture such biologics is often...
Both type I interferon (IFN-I) and CD40 play a significant role in various infectious diseases, including malaria autoimmune disorders. is mostly known to function adaptive immunity, but previous observations of elevated levels early after infection mice led us investigate its roles innate IFN-I responses disease control. Using Plasmodium yoelii nigeriensis N67 C57BL/6 mouse model, we showed that infected CD40-/- had reduced STING serum IFN-β day-2 post infection, higher day-4 parasitemia,...
Invading pathogens trigger specific host responses, an understanding of which might identify genes that function in pathogen recognition and elimination. In this study, we performed trans-species expression quantitative trait locus (ts-eQTL) analysis using genotypes the Plasmodium yoelii malaria parasite phenotypes mouse gene expression. We significantly linked 1,054 to genetic loci (LOD score ≥ 3.0). Using LOD patterns, produced results differed from direct expression-level clustering,...
Neuropathic pain causes great distress among patients; however, its response to traditional analgesia techniques remains sub-optimal. There has been progress in stem cell research for neuropathic treatment; effective homing problematic. This study aimed establish Fe3O4@polydopamine(PDA)-labeled mesenchymal cells (MSCs); moreover, we guide MSCs using a magnetic field the spinal cord segments showing pain-related responses allow MSC and gathering, advance, order fully employ their repair...
ABSTRACT In this study, we investigate the effect of neuregulin 4 (NRG4) on podocyte damage in a mouse model diabetic nephropathy (DN) and elucidate underlying molecular mechanisms. vivo experiments were conducted using C57BL/6 DN to determine NRG4 proteinuria injury, vitro performed with conditionally immortalized podocytes treated high glucose assess protective effects injury. Autophagy‐related protein levels related signaling pathways evaluated both vitro. The involvement adenosine...
In Saccharomyces cerevisiae, the Rho-type GTPase Cdc42 regulates polarized growth through its effectors, including p21-activated kinases (PAKs) Ste20, Cla4, and Skm1. Previously, we demonstrated that Ste20 interacts with several proteins involved in sterol synthesis are crucial for cell polarization. Under anaerobic conditions, sterols cannot be synthesized need to imported into cells. Here, show Skm1 form a complex Sut1, transcriptional regulator promotes uptake. All three PAKs can...
Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased lung cancer. The present study aimed investigate the changes breast cancer and association between clinical characteristics, elucidate diagnostic prognostic significance of data RNA-sequencing values 1,104 patients with were downloaded from Cancer Genome Atlas database....
Perivascular spaces (PVSs) as the anatomical basis of glymphatic system, are increasingly recognized potential imaging biomarkers neurological conditions. However, it is not clear whether enlarged PVSs associated with alcohol-related brain damage (ARBD). We aimed to investigate effect long-term alcohol exposure on dyslipidemia and system in ARBD. found that patients ARBD exhibited significantly enlargement frontal cortex basal ganglia, well a notable increased levels total cholesterol (TC)...