A5047292905- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Radio Astronomy Observations and Technology
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Astrophysics and Cosmic Phenomena
- Acute Ischemic Stroke Management
- Glycogen Storage Diseases and Myoclonus
- Nuclear Receptors and Signaling
- Obsessive-Compulsive Spectrum Disorders
- Balance, Gait, and Falls Prevention
- Galaxies: Formation, Evolution, Phenomena
- Adaptive optics and wavefront sensing
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Muscle activation and electromyography studies
- Cerebrovascular and Carotid Artery Diseases
Royal Brisbane and Women's Hospital
2016-2025
The University of Queensland
2016-2025
Stanford University
2024
The University of Sydney
2015-2024
Royal Prince Alfred Hospital
2023-2024
Cork County Council
2016-2019
Wesley Hospital
2017-2018
Wesley Research Institute
2017-2018
Commonwealth Scientific and Industrial Research Organisation
1985-2016
Astronomy and Space
2015-2016
Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is powerful antioxidant. It absorbed orally and concentrates within mitochondria where it has been shown protect against damage. We enrolled 128 newly diagnosed untreated patients with PD in double-blind study two doses compared placebo explore the hypothesis that, over 12 months, would slow progression measured by clinical scores, particularly Unified...
Assigning meaning to words, sounds, and objects requires stored conceptual knowledge plus executive mechanisms that shape semantic retrieval according the task or context. Despite essential role of control in cognition, its neural basis remains unclear. Neuroimaging patient research has emphasized importance left inferior frontal gyrus (IFG)—however, impaired can also follow temporoparietal lesions, suggesting this function may be underpinned by a large-scale cortical network. We used...
The Fourier inversion method for reconstruction of images in computerized tomography has not been widely used owing to the perceived difficulty interpolating from polar or other measurement grids Cartesian grid required fast numerical inversion. Although is recognized as being computationally faster than back-projection parallel ray projection data, artifacts resulting inaccurate interpolation have generally limited application method. This paper presents a efficient gridding algorithm which...
Anxiety disorders are common in Parkinson's disease (PD) patients, yet poorly studied. We examined the prevalence of anxiety PD, investigated association between anxiety, and presentation progression studied for first time contribution putative risk factors PD. A case-series 79 PD patients recruited from neurology out-patient clinics was using DSM-IV criteria. The Unified Disease Rating Scale Hoehn Yahr Staging were employed to understand relationship disorders, clinical severity validated...
The Australia SKA Pathfinder (ASKAP) is a new telescope under development as world-class high-dynamic-range wide-field-of-view survey instrument. It will utilize focal plane phased array feeds on the 36 12-m antennas that compose array. large amounts of data present huge computing challenge, and ASKAP store products in an archive after near real-time pipeline processing. This powerful instrument be deployed at radio-quiet observatory, Murchison Radio-astronomy Observatory midwest region...
Abstract Background There is reported to be a decline in immune function and an alteration the frequency of circulating lymphocytes with advancing age. are also differences ageing lifespan between males females. We performed this study see if there were females different lymphocyte subsets Results Using flow cytometry we have examined populations peripheral blood leukocytes purified from healthy subjects age ranging third tenth decade. used linear regression analysis determine relationship...
Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of association studies Parkinson disease (PD) based on populations Caucasian descent. The extent to which these effects are consistent across different is unknown.Investigators from the Genetic Epidemiology Parkinson's Disease Consortium were invited participate study. A total 11 SNPs genotyped 8,750 cases and 8,955 controls. Fixed as well random models used provide summary risk estimates for variants. We...
Background and Purpose— To assess the prevalence of premorbid undernutrition its impact on outcomes 1 month after stroke. Methods— The study recruited from consecutive stroke admissions during a 10-month period. Premorbid nutritional status (using subjective global assessment [SGA]), functioning (modified Rankin scale [MRS]), severity (National Institutes Health Stroke Scale [NIHSS] score) were assessed at admission. associations between status, poor outcome (defined as MRS ≥3), mortality...
Abstract There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease. The objective this study was to determine efficacy three treatments (nonpharmacological therapy, fludrocortisone, and domperidone). Phase I assessed compliance, safety, nonpharmacological measures. II a double‐blind randomized controlled crossover trial two medications. Primary outcome measures consisted domain Composite Autonomic Symptom Scale (COMPASS‐OD), clinical global...
Introduction: The application of low frequency (1 Hz) Repetitive Transcranial Magnetic Stimulation (rTMS) to right hemisphere (RH) language homologues in non-fluent aphasic populations has yielded improvements behavioural function, up
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the loss of upper cortical and lower motor neurons. ALS causes death within 2–5 years diagnosis. Diet body mass index influence clinical course disease, however there limited information about expression metabolic proteins fat-derived cytokines (adipokines) in ALS. In healthy controls subjects with ALS, we have measured levels adipokines that metabolism. We find altered active ghrelin, gastric...
We previously identified a homozygous mutation in the Golgi SNAP receptor complex 2 gene (GOSR2) six patients with progressive myoclonus epilepsy. To define syndrome better we analysed clinical and electrophysiological phenotype 12 GOSR2 mutations, including new unrelated subjects. Clinical presentation was remarkably similar early onset ataxia (average years of age), followed by myoclonic seizures at average age 6.5 years. Patients developed multiple seizure types, generalized tonic clonic...
Background. Motor and nonmotor symptoms negatively influence Parkinson's disease (PD) patients' quality of life. Mindfulness interventions have been a recent focus in PD. The present study explores effectiveness manualized group mindfulness intervention tailored for PD improving both motor neuropsychiatric deficits Methods. Fourteen patients completed an 8-week that included 6 sessions. Five Facet Questionnaire (FFMQ), Geriatric Anxiety Inventory, Hamilton Depression Rating Scale, Cognitive...
We report the discovery of a new 21-cm HI absorption system using commissioning data from Boolardy Engineering Test Array Australian Square Kilometre Pathfinder (ASKAP). Using 711.5 - 1015.5 MHz band ASKAP we were able to conduct blind search for line in continuous redshift range between $z = 0.4$ and 1.0, which has, until now, remained largely unexplored. The is detected at 0.44$ towards GHz-peaked spectrum radio source PKS B1740$-$517 demonstrates ASKAP's excellent capability performing...