A5088517488- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Dysphagia Assessment and Management
- Sarcoma Diagnosis and Treatment
- Voice and Speech Disorders
- RNA regulation and disease
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Cardiac tumors and thrombi
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Chemical synthesis and alkaloids
- Heme Oxygenase-1 and Carbon Monoxide
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Neurological diseases and metabolism
- High Altitude and Hypoxia
- Electroconvulsive Therapy Studies
- PARP inhibition in cancer therapy
- Traditional and Medicinal Uses of Annonaceae
- Intracranial Aneurysms: Treatment and Complications
- Amyotrophic Lateral Sclerosis Research
- Bone Tumor Diagnosis and Treatments
Sendai Nishitaga National Hospital
2015-2024
Juntendo University
2007-2014
Centre for Addiction and Mental Health
2014
University of Toronto
2014
Juntendo University Urayasu Hospital
2008-2010
Ministry of Education, Culture, Sports, Science and Technology
2006
Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and an animal model based on increased polysialic acid-like immunoreactivity. Changes neurogenesis often appear parallel to changes angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) its receptors VEGFR-1 (Flt-1) VEGFR-2 (Flk-1). Using immunohistochemistry, identified this study upregulation VEGF substantia nigra but not...
Early identification of the poor prognosis subtype by surrogate markers would be advantageous for selecting treatments Parkinson's disease (PD). The aim present study was to test whether plasma neurofilament light chain (NF-L), total tau (t-tau), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), fatty acid-binding protein 3 (FABP3), and phosphorylated (p-tau) can used as prognostic biomarkers in PD. In study, both retrospective prospective studies were performed. Plasma samples at baseline...
Background In recent years, there has been increasing evidence that several lipid metabolism abnormalities play an important role in the pathogenesis of neurodegenerative diseases. However, it is still unclear which most Plasma metabolomics (lipidomics) shown to be unbiased method can used explore lipidomics diseases performed only idiopathic Parkinson’s disease (IPD) and Alzheimer’s (AD), comprehensive studies are needed clarify pathogenesis. Methods this study, we investigated plasma...
An increase in the global aging population is leading to an age-related conditions such as dementia and movement disorders, including Alzheimer's disease (AD), Parkinson's (PD), with Lewy bodies (DLB). The accurate prediction of risk factors associated these disorders crucial for early diagnosis prevention. Biomarkers play a significant role diagnosing monitoring diseases. In neurodegenerative like α-synucleinopathies, specific biomarkers can indicate presence progression disease. We...
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder characterized by motor and nonmotor symptoms. Several features have prognostic importance been used as key indicators for identifying clinical subtypes. However, the symptom-based classification approach has limitations with respect to stability of obtained subtypes.The purpose this study was identify subtypes PD using nuclear imaging biomarkers targeting cardiac sympathetic nervous nigro-striatal systems compare patterns...
Abstract Granulocyte colony‐stimulating factor (G‐CSF) has been used for the treatment of neutropenia in hematologic disorders. The neuroprotective effects G‐CSF were reported neurological disease models. In present study, we examined whether can protect dopaminergic neurons against MPTP‐induced cell death a mouse model Parkinson's disease. Mice one group injected intraperitoneally with MPTP five consecutive days, those another and intraperitoneal at 2 days 1 day before first injection, 30...
Background: Recently, the hypothesis that pathological α-Synuclein propagates from gut to brain has gained attention. Although results animal studies support this hypothesis, specific mechanism remains unclear. This study focused on intestinal fatty acid-binding protein (FABP2), which is one of subtypes acid binding proteins localizing in gut, with FABP2 involved gut-to-brain propagation α-synuclein. The aim was clarify significance pathogenesis and progression synucleinopathy. Methods: We...
Parkinson’s disease (PD) and multiple system atrophy are types of adult-onset neurodegenerative disorders named synucleinopathies, which characterized by prominent intracellular α-synuclein (αSyn) aggregates. We have previously found that αSyn aggregates the vulnerability dopaminergic neurons in mouse brain partly associated with expression fatty acid-binding protein 3 (FABP3, heart FABP). However, it remains to be elucidated whether FABP3 accumulation is human tissues. Here, we...
Increasing evidence suggests that alpha-synuclein (αSyn) accumulation in cholinergic and adrenergic fibers the skin is a useful biomarker to diagnose idiopathic Parkinson's disease (IPD). It has been widely reported phosphorylated αSyn (p-αSyn) deposits autonomic IPD are skin, but other tissue localizations have not fully investigated.
A 60-year-old male was first treated for World Health Organization (WHO) grade II chondrosarcoma arising from the ring finger manifesting as painful swelling. Four years later, patient presented with cerebral infarction. Echocardiography revealed a tumor occupying left atrium. He underwent open heart surgery and identified metastatic malignant transformation to WHO III lesion. Five months following cardiac surgery, suffered generalized seizure. Cerebral magnetic resonance imaging multiple...
A rare case of de novo formation dural and osteodural arteriovenous fistulas after encephalitis is presented. We review discuss the etiological angiogenetic factors processes in intracranial formation. Local tissue hypoxia may have played a role initial step causing sprouting angiogenesis as main pathogenesis DAVFs