A5079955356- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Cerebrospinal fluid and hydrocephalus
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Dysphagia Assessment and Management
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Spinal Dysraphism and Malformations
- Cerebrovascular and genetic disorders
- Traumatic Brain Injury Research
- Hereditary Neurological Disorders
- Obstructive Sleep Apnea Research
- Neurogenetic and Muscular Disorders Research
- Clostridium difficile and Clostridium perfringens research
- Amino Acid Enzymes and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Nerve injury and regeneration
- Glycogen Storage Diseases and Myoclonus
- Infant Health and Development
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
First Affiliated Hospital of Zhengzhou University
2020-2024
Zhengzhou University
2020-2024
Central South University
2018-2020
Xiangya Hospital Central South University
2018-2020
Allen Institute for Brain Science
2020
Icahn School of Medicine at Mount Sinai
2020
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and an independent risk factor for cognitive impairment. However, it remains unclear how OSA linked to In the present study, we found correlation between morphological changes of perivascular spaces (PVSs) impairment in patients. Moreover, developed a novel set dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods evaluate fluid dynamics glymphatic drainage system. We that inflow outflow parameters...
Alpha-synuclein (α-syn) pathology is the hallmark of Parkinson's disease (PD). The leucine-rich repeat kinase 2 (LRRK2) gene a major-effect risk for sporadic PD (sPD). However, what environmental factors may trigger formation α-syn in carriers LRRK2 variants are still unknown. Here, we report that markedly increased abundance Escherichia coli (E. coli) intestinal microbiota was detected variant(R1628P or G2385R) with sPD compared without sPD. Animal experiments showed E. administration...
The neuropathological feature of multiple system atrophy (MSA), a fatal adult-onset disorder without effective therapy, is the accumulation pathological α-synuclein (α-Syn) in central nervous (CNS). Here we show that α-Syn exists nerve terminals detrusor and external urethral sphincter (EUS) patients with MSA. Furthermore, α-Syn-preformed fibrils (PFFs) injected EUS or TgM83+/− mice initiated transmission from urogenital tract to brain via micturition reflex pathways, these developed...
Introduction: This study was designed to explore the associations between impaired cognition in chronic kidney disease (CKD) patients and dysfunction of glymphatic system. Method: Data were obtained from 77 CKD 50 age-matched healthy control individuals First Affiliated Hospital Zhengzhou University. stratified into with without cognitive function. T2-weighted magnetic resonance imaging results used assess area ratios for perivascular space ventricles participants, while Montreal Cognitive...
SNCA/α-synuclein is a major component in the Lewy body (LB), pathological hallmark of Parkinson disease (PD) and dementia with (DLB), collectively known as synucleinopathies. can be secreted from neurons transmitted to neighboring cells including glia, which underlie spreading LB pathology described by Braak colleagues. We recently have investigated mechanism significance for microglia, prototypic phagocyte brain, engulfing controlling homeostasis brain. Using microglia-specific...
Introduction Generalized anxiety disorder (GAD) is one of the most enduring disorders, being associated with increased systemic inflammation. However, trigger and mechanisms underlying activation inflammatory cytokine responses in GAD remain poorly understood. Materials methods We characterized ear canal microbiome patients through 16S rRNA gene sequencing metagenomic identified serum markers patients. Spearman correlations were applied to test relationship between microbiota changes Results...
Progressive supranuclear palsy (PSP) is characterized by the presence of hyperphosphorylated and misfolded tau aggregates in neurons glia. Recent studies have illuminated prion-like cell-to-cell propagation via exosomes. Recognizing potential significance excretion through urine as a crucial pathway for eliminating pathological from central nervous system, this study aimed to investigate whether exosomes derived PSP-Richardson's syndrome (PSP-RS) patients can elicit pathology PSP-like symptoms mice.
The meningeal lymphatic vessels (mLVs) in central nervous system (CNS) have been validated by rodent and human studies. mLVs play a vital role draining soluble molecules trafficking lymphocytes, antigens antibodies from CNS into cervical lymph nodes (CLNs). This indicates that may serve as link between the peripheral immune system, perhaps involving neuroinflammatory disease. However, morphology drainage function of patients with disease, such neuromyelitis optica spectrum disorders (NMOSD),...
Abstract Objective Parkinson’s disease (PD) and essential tremor (ET) are the two most common movement disorders. A significant overlap in clinical features, epidemiology, imaging, pathology suggests that PD ET may also share genetic risk factors. Previous studies have only assessed a limited number of ET‐associated genes patients vice versa. Consequently, association between remains incompletely characterized. In this study, we systematically investigated potential rare coding variants PD,...
Inflammation has been demonstrated to be involved in Parkinson’s disease (PD) pathogenesis. There were evidences that the disturbance of protective function IL-10 gene contributed PD. In our study, haplotype analyses conducted rs1800871 and rs1800872 on 371 PD patients. Because two SNPs exposed significant linkage disequilibrium by Haploview software, we included 177 carriers both 190 noncarriers clinical phenotype analyses. As nonmotor symptoms, score gastrointestinal dysfunction domain...
SNCA-rs11931074 had been demonstrated to be strongly correlated with PD risk. However, there was lack of comprehensive analysis SNCA-rs11931074-related clinical features which may help explain heterogeneity PD. In our study, we performed association analyses on the relationship between and motor symptoms, nonmotor comorbidities in 611 rs11931074 carriers 113 noncarriers were enrolled. phenotype analyses, Unified Parkinson's Disease Rating Scale part II (UPDRS II) III III) scores lower than...
The clinical data of 7 patients with anti-α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid receptor (AMPAR) encephalitis admitted to the First Affiliated Hospital Zhengzhou University from January 2015 2024 were retrospectively collected, and 87 cases complete literature included for summary analysis. Seven casess exhibited limbic encephalitis, including 3 lung cancer 1 thymoma. All treated glucocorticoids and/or human immunoglobulin. Four concurrent tumors followed up 25 months all...
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant inherited neurodegenerative disorder for which there currently no cure, nor effective treatment strategy.
Abstract Hypertrophic olivary degeneration (HOD) is a transsynaptic characterized by the disruption of dentato-rubro-olivary tract, region also known as Guillain-Mollaret triangle (GMT), which often occurs because posterior fossa or brainstem lesions. Infratentorial cerebrovascular diseases (ICVD) has been linked to HOD in previous studies. The underlying mechanism ICVD patients developed HOD, however, remains undetermined. In this study, we analyzed clinical features 334 with and results...