A5019633275- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Nerve injury and regeneration
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Trigeminal Neuralgia and Treatments
- Transcranial Magnetic Stimulation Studies
- Nuclear Receptors and Signaling
- Balance, Gait, and Falls Prevention
- Acute Ischemic Stroke Management
- Facial Nerve Paralysis Treatment and Research
- Cancer Treatment and Pharmacology
- RNA regulation and disease
- Parkinson's Disease and Spinal Disorders
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
Shanghai Sunshine Rehabilitation Center
2021-2025
Tongji Hospital
2016-2025
Tongji University
2016-2025
Shanghai Clinical Research Center
2021-2023
Ministry of Education of the People's Republic of China
2020
GTx (United States)
2020
Yangpu Hospital of Tongji University
2018
Medizinische Hochschule Hannover
2009
Brain cancer is a kind of tough carcinoma because the blood-brain barrier (BBB) remains formidable obstacle in medicine. Curcumin (Cur) was determined to have anticancer potency on several kinds carcinoma. However, its medical application limited poor bioavailability, unsatisfying dispersity and rapid metabolism vivo. In this study, Cur delivered by nanostructured lipid carriers (NLCs) for brain treatment. The physiochemical characters NLC-Cur were detected using high-performance liquid...
Exercise has been proposed as an effective non-pharmacological management for Parkinson's disease (PD) patients. Irisin, a recently identified myokine, is increased by exercise and plays pivotal roles in energy metabolism. However, it remains unknown whether irisin any protective effects on PD. Here, we found that serum levels of PD patients were markedly elevated after 12-week regular exercise, which had positive correlation with improved balance function scored Berg Balance Scale....
China and the world are facing severe population aging an increasing burden of age-related diseases. Aging brain causes major diseases, such as neurodegenerative diseases stroke. Identifying biomarkers for effective assessment establishing a system could facilitate development intervention strategies prevention treatment aging-related Thus, experts from Biomarker Consortium (ABC) have combined latest research results practical experience to recommend form expert consensus, aiming provide...
Stroke is a prevalent, severe, and disabling health-care issue on global scale, inevitably leading to motor cognitive deficits. It has become one of the most significant challenges in China, resulting substantial social economic burdens. In addition medication surgical interventions during acute phase, rehabilitation treatment plays crucial role stroke care. Robotic technology takes distinct advantages over traditional physical therapy, occupational speech increasingly gaining popularity...
Abstract Botulinum toxin (BT) therapy is a complex and highly individualised defined by treatment algorithms injection schemes describing its target muscles their dosing. Various consensus guidelines have tried to standardise improve BT therapy. We wanted update by: (1) Acknowledging recent advances of algorithms. (2) Basing dosing tables on statistical analyses real-life data 1831 injections in 36 different 420 dystonia patients 1593 31 240 spasticity patients. (3) Providing more detailed...
Objective The primary aim of this study was to investigate the effects two different patterns rehabilitation training on movement and balance function in patients with idiopathic Parkinson disease. Design Forty disease were randomized into tai chi group (n = 20) or multimodal exercise 20). Outcome measures assessed at baseline after 12 wks exercise. Balance using Berg Scale, by Unified Parkinson’s Disease Rating Scale—Motor Examination, stride length, gait velocity, Timed Up Go Test. Results...
Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi (GSTP1) are commonly upregulated in GBM. NQO1 GSTP1 decrease the formation of reactive oxygen species (ROS), which mediates oxidative stress promotes GBM cell proliferation.
Introduction. Phantom limb pain and sensations are common in amputees. The pathophysiology remains unclear the treatment difficult often unsuccessful. Opioids frequently used when non-narcotics have failed, but not effective many cases. We report on three phantom stump patients, refractive to previous treatments, who were successfully treated with botulinum toxin A (BoNT-A). Methods. Three patients had previously undergone amputation of their leg due accident (N = 2) or injury by a landmine...
Objective Intracranial blood blister-like aneurysm (BBA) is a rare type of that lacks all layers the arterial wall. These fragile aneurysms have propensity to rupture with minimal manipulation, which makes them hazardous and difficult treat. The present study evaluated safety feasibility endovascular treatment BBAs Willis covered stent. Materials Thirteen patients (7 men 6 women, age range 28–68 years) who presented ruptured were treated stent retrospectively reviewed. Results procedures...
Glioblastoma (GBM) is the most common and aggressive brain tumor, associated with high levels of reactive oxidative species (ROS) due to metabolic signaling aberrations. High ROS are detrimental cells, but it remains incompletely understood how cancer cells cope adverse effects. Here we show that C/EBPβ, a responsive transcription factor, regulates NQO1 GSTP1, two antioxidative reductases, which neutralize in GBM mediates their proliferation. C/EBPβ upregulated EGFR overexpressed inversely...
Parkinson’s disease (PD) is a neurodegenerative characterized by the gradual loss of dopaminergic (DA) neurons in substantia nigra (SN) and formation intracellular Lewy bodies (LB) brain, which aggregates α -synuclein ( -Syn) as main component. The interest flavonoids potential neuroprotective agents increasing due to its high efficiency low side effects. Baicalin one flavonoid compounds, predominant isolated from Scutellaria baicalensis Georgi. However, key molecular mechanism can prevent...
T lymphocytes are involved in the pathogenesis of Parkinson's disease (PD), while heterogeneity T-cell subpopulations remains elusive. In this study, we analyzed up to 22 115 PD patients and 60 matched healthy controls (HC) using flow cytometry. We found that exhibited decreased naïve CD8+ cells (CD3+ CD45RA+ CD45RO-) increased late-differentiated CD4+ CD28- CD27-), compared HC, which were not affected by anti-parkinsonism medication administration. The proportion was positively correlated...
Introduction Brain-computer interfaces (BCIs) have the potential in providing neurofeedback for stroke patients to improve motor rehabilitation. However, current BCIs often only detect general intentions and lack precise information needed complex movement execution, mainly due insufficient execution features EEG signals. Methods This paper presents a sequential learning model incorporating Graph Isomorphic Network (GIN) that processes sequence of graph-structured data derived from EMG...
Surface electromyography (sEMG) signals are electrical released by muscles during movement, which can directly reflect the muscle conditions various actions. When a series of continuous static actions connected along temporal axis, sequential action is formed, more aligned with people's intuitive understanding real-life movements. The acquired known as sEMG signals, including an additional dimension sequence, embodying richer features compared to signals. However, existing methods show...