A5103122545- Amyotrophic Lateral Sclerosis Research
- Botulinum Toxin and Related Neurological Disorders
- Ion channel regulation and function
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Natural Antidiabetic Agents Studies
- Intensive Care Unit Cognitive Disorders
- Liver Disease Diagnosis and Treatment
- Peripheral Nerve Disorders
- Nicotinic Acetylcholine Receptors Study
- Liver Disease and Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Essential Oils and Antimicrobial Activity
- Nerve Injury and Rehabilitation
- Trigeminal Neuralgia and Treatments
- Hereditary Neurological Disorders
- Pain Management and Treatment
- Respiratory Support and Mechanisms
- Laser Applications in Dentistry and Medicine
- Congenital Anomalies and Fetal Surgery
- Neurogenetic and Muscular Disorders Research
Yasuj University of Medical Sciences
2012-2023
International Neuroscience Institute
2008-2016
University of Lübeck
2011-2016
Tehran University of Medical Sciences
2011-2012
Medizinische Hochschule Hannover
2000-2010
Otto-von-Guericke University Magdeburg
2009
Deutsche Forschungsgemeinschaft
2005
Pancreatic Cancer Action Network
2003
Cervical dystonia (CD) is the most common form of adult-onset focal dystonia, and botulinum toxin A (BoNT-A) has become first-line treatment for this condition.In work, we present data 207 CD patients treated with BoNT-A 6.7 +/- 3.5 years. One hundred sixty-three were Dysport (mean dose, 389 144 U) 44 Botox 145 U).The mean clinical benefit, based on a 0-3 scale (0=no effect, 1=slight, 2=moderate 3=marked improvement) was similar (2.5 0.3) (2.2 0.4). Adverse events mild both products. Fewer...
Abstract The administration of dopamine agonists in Parkinson's disease has been associated with impulse control disorders, particular, pathological gambling. In the present investigation, 17 patients without disorders and matched participants were offered choices between monetary rewards (ranging 11 80 euros) available immediately larger (between 25 85 after delays ranging from 7 to 186 days. Participants had a 1‐in‐6 chance winning reward that they chose on 1 randomly selected trial....
Introduction. Phantom limb pain and sensations are common in amputees. The pathophysiology remains unclear the treatment difficult often unsuccessful. Opioids frequently used when non-narcotics have failed, but not effective many cases. We report on three phantom stump patients, refractive to previous treatments, who were successfully treated with botulinum toxin A (BoNT-A). Methods. Three patients had previously undergone amputation of their leg due accident (N = 2) or injury by a landmine...
Many traditional treatments have been recommended in the alternative system of medicine for treatment diabetes mellitus. Juglans regia is one medicinal plants used Iranian as a diabetes, but little scientific documentation supports its antidiabetic action. The purpose this study was to investigate effect J. leaves type 1 induced animal model. Materials and methods: Four groups animals were selected. Group I fed normal diet. Animals II, III, IV received streptozotocin. III treated with leaf...
Abstract Background Besides the defining involvement of upper and lower motor neurons, extramotor structures has been increasingly acknowledged in amyotrophic lateral sclerosis (ALS). Methods Here we investigated a group 14 mildly to moderately affected ALS patients age-matched healthy control participants using cortical thickness analysis. Cortical was determined from high resolution 3D T1 magnetic resonance images involved semiautomatic segmentation grey white matter, alignment...
Protein arginine methyltransferase 7 (PRMT7) is an enzyme that methylates residues within protein substrates, influencing biological processes such as gene expression regulation, stress response, neuromuscular development, and adipogenesis. PRMT7-related syndrome a neurodevelopmental disorder characterized by growth impairment, skeletal endocrine abnormalities, hypotonia, digital craniofacial malformations, seizures, obesity. In murine models, PRMT7 has been shown to positively regulate...
Insufficient amounts of survival motor neuron protein is leading to one the most disabling neuromuscular diseases, spinal muscular atrophy (SMA). Before current study, detailed characteristics Iranian patients with SMA had not been determined.To describe key demographic, clinical, and genetic registered in Registry (IRSMA).IRSMA has established since 2018, were recorded according methods treat disease (TREAT-NMD) project.By October 1, 2022, 781 5q registered. Of them, 164 died, majority them...
Spasticity is a complex disorder that causes significant disability in affected patients. We here present long-term results of botulinum toxin type A (BoNT-A) treatment spasticity various etiologies the upper and lower limbs.We evaluated BoNT-A with Dysport Botox for up to 12 years 137 patients etiologies. The focus was laid on efficacy, dosage, safety side effects over time retrospective analysis database our movement clinic.The mean clinical benefit, latency duration response were...
The effects of extracellular pH (6.2, 7.4 and 8.2) 0.1 mM mexiletine, a channel blocker the lidocaine type, are studied on two mutations fourth voltage sensor Nav1.4 sodium channel, R1448H/C. fast inactivated state to which mexiletine preferentially binds is destabilized by mutations. By contrast expected low response R1448H/C carriers, particularly effective in preventing exercise-induced stiffness paralysis from these patients suffer. Our measurements performed whole-cell mode stably...
Missense mutations of the human skeletal muscle voltage-gated Na+ channel (hSkM1) cause a variety neuromuscular disorders. The mutation R1448H results in paramyotonia congenita and causes cold-induced myotonia with subsequent paralysis. M1360V an overlapping syndrome both K+-induced weakness myotonia. molecular mechanisms temperature dependence these disorders are not well understood. Therefore we investigated physiological parameters at different temperatures. Channel proteins were...
It can be difficult to detect upper motor neuron (UMN) involvement in early amyotrophic lateral sclerosis (ALS). The present study tested the usefulness of mirror movements (MMs), i.e., contralateral coactivation hand muscles, as a UMN sign ALS. Thirty-seven patients with possible, probable or definite ALS and 19 suspected without clinical signs involvement, 21 disease controls 15 healthy volunteers were included. MMs studied clinically, electromyographically by transcranial magnetic...
In Guillain-Barré syndrome (GBS), immunoglobulin G (IgG) antibodies block neuromuscular transmission pre- and postsynaptically thus are of potential pathogenic relevance. We investigated whether IgG from GBS patients has a direct interaction with nicotinic acetylcholine receptor (nAChR) channels. Purified fractions six that blocked in previous study were analyzed by the patch-clamp technique combination an ultrafast system for solution exchange. Sera three other inflammatory neurological...