A5036618500- Crystallization and Solubility Studies
- Molecular Junctions and Nanostructures
- X-ray Diffraction in Crystallography
- Quantum and electron transport phenomena
- Enzyme Catalysis and Immobilization
- Asymmetric Synthesis and Catalysis
- Enzyme Structure and Function
- Plant tissue culture and regeneration
- Organic Light-Emitting Diodes Research
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Traditional Chinese Medicine Analysis
- Fungal Biology and Applications
- Magnetism in coordination complexes
- Aldose Reductase and Taurine
- Organic and Molecular Conductors Research
- Organic Electronics and Photovoltaics
- Cyclopropane Reaction Mechanisms
- Plant Physiology and Cultivation Studies
- Carbohydrate Chemistry and Synthesis
- Graphene research and applications
- Plant Water Relations and Carbon Dynamics
Shandong Normal University
2017-2025
Hong Kong University of Science and Technology
2024-2025
University of Hong Kong
2024-2025
Henan University
2015-2024
Zhejiang University of Science and Technology
2023-2024
Hangzhou Botanical Garden
2017-2024
University of California, Los Angeles
2024
Tianjin Medical University
2024
Chongqing University
2023
East China Jiaotong University
2023
Abstract Cardiovascular diseases (CVDs) continue to drive global mortality rates, underscoring an urgent need for advancements in healthcare solutions. The development of point‐of‐care (POC) devices that provide rapid diagnostic services near patients has garnered substantial attention, especially as traditional systems face challenges such delayed diagnoses, inadequate care, and rising medical costs. advancement machine learning techniques sparked considerable interest research engineering,...
We explore the possibility that hyperfine interaction causes recently discovered organic magnetoresistance (OMAR) effect. deduce a simple fitting formula from Hamiltonian relates saturation field of OMAR traces to coupling constant. compare results literature values for this parameter. Furthermore, we apply an excitonic pair mechanism model based on interaction, previously suggested by others explain various magnetic-field effects in organics, data. Whereas can few key aspects experimental...
A new strategy for the construction of optically active 5'-CF3 spiro[pyrrolidin-3,2'-oxindole] was described. series unprecedented 1,3-dipoles were obtained by condensation CF3CH2NH2 with isatins. The 1,3-dipolar cycloaddition reactions these ketimines enals gave products bearing four contiguous stereogenic centers in excellent yields, diastereoselectivities and enantioselectivities.
Abstract Aim Conservation strategies must anticipate how climate change may alter the geographic distributions of limited food resources for highly specialized species. Here, we use bamboo as a case study to investigate change‐induced changes in species diversity and discuss protect critical giant pandas. Location Giant panda habitats. Methods Using niche‐based model most updated projections, projected current future distribution 16 under no universal dispersal assumptions. We then assessed...
Antimicrobial peptide has the potential to be developed as new kind of antimicrobial agents with novel action mechanism. However, susceptibility protease is a drawback for peptides clinical used. d-amino acid substitution can one way increase proteolytic stability peptides. In present study, we synthesized d-lysines substituted analog (d-lys-MPI) and d-enantiomer polybia-MPI (D-MPI) improve resistance polybia-MPI. Our results showed that, its partially d-lys-MPI was increased. it lost...
Abstract We report a synthetic strategy for chemoselective switch and diastereo‐divergent approach the asymmetric reaction of 5 H ‐oxazol‐4‐ones N ‐itaconimides catalyzed by l ‐ tert ‐leucine‐derived tertiary amine–urea compounds. The was modulated to harness either tandem conjugate addition–protonation or [4+2] cycloaddition as major product with excellent enantio‐ diastereoselectivities. Subjecting enantio‐enriched products basic silica gel reagent yields diastereomer vis‐à‐vis directly...
Abstract We examined the warming effects on stomatal frequency, aperture size and shape, their spatial distribution pattern of maize ( Z ea may L .) leaves using a light microscope, an electron scanning geostatistic techniques. A field manipulative experiment was conducted to elevate canopy temperature by 2.08°C, average. found that experimental had little effect density, but significantly increased index due reduction in number epidermal cells under treatment. Warming also decreased length...
Background To date, several studies have indicated a major role for microRNAs (miRNAs) in regulating plant development, but miRNA-mediated regulation of the developing somatic embryo is poorly understood, especially during early stages embryogenesis hardwood plants. In this study, Solexa sequencing and miRNA microfluidic chips were used to discover conserved species-specific miRNAs hybrid yellow poplar (Liriodendron tulipifera×L. chinense). Methodology/Principal Findings A total 17,214,153...
The β-isocupreidine, a cinchonine derived alkaloid, catalyzed asymmetric SN2′–SN2′ reaction between N-2,2,2-trifluoroethylisatin ketimines and MBH type carbonates was realized in simple efficient way. A series of chiral α-trifluoromethylamines were prepared with excellent yields stereoselectivities. subsequent easy process deprotection gave γ-trifluoromethyl-α-methylenelactam stereoselective manner.
A catalytic asymmetric method for the synthesis of 2-CF3 chromanes has been described. Generally, squaramide-catalyzed cascade reaction 2-hydroxychalcones with β-CF3-nitroalkenes gave CF3-containing heterocyclic compounds bearing three contiguous stereogenic centers in excellent yields, diastereoselectivities, and enantioselectivities.
Carbonyl reductase (CR)-catalyzed asymmetric reduction offers an approach for producing t-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-1b), which serves as a key building block in atorvastatin (Liptor). However, controlling the stereopreference of CR with desired selectivity remains challenging because natural CRs usually exhibit Prelog preference. Moreover, transferring knowledge from engineered anti-Prelog to other is difficult. Herein, residues that regulate Kluyveromyces marxianus...
Abstract Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization. Exosomes show potential as ideal vehicles. However, an affordable generalizable system for efficient loading on exosomes remain lacking. Here, we identified Exosomal Anchor DNA Aptamer (EAA) via SELEX against immobilized with our proprietary CP05 peptides. EAA shows high binding affinity to different enables nucleic acid drugs...
We have developed a new family of dipeptide-based multifunctional Brønsted base organocatalysts capable the asymmetric [4 + 2] annulation 5<italic>H</italic>-thiazol-4-ones with electron-deficient alkenes.
Abstract Enzyme engineering usually generates trade‐offs between activity, stability, and selectivity. Herein, we report semirational of an aldo–keto reductase (AKR) Km AKR for simultaneously enhancing its thermostability catalytic activity. Previously, constructed M9 (W297H/Y296W/K29H/Y28A/T63M/A30P/T302S/N109K/S196C), which showed outstanding activity towards t ‐butyl 6‐chloro‐(3 R ,5 S )‐dihydroxyhexanoate ((3 )‐CDHH), 6‐cyano‐(3 )‐dihydroxyhexanoate, the key chiral building blocks...
Highly enantio- and chemo-selective 1,4-conjugate addition process of 5H-thiazol-4-ones with maleimides or 1,4-naphthoquinones, 5H-oxazol-4-ones were performed under a dipeptide-based tertiary amine (DP-UAA) catalyst. A series valuable N,S- N,O-containing heterocyclic compounds excellent disastereo-selectivities (up to >99% ee, > 20:1 dr) attained.
Helicenes with persistent luminescence have received relatively little attention, despite their demonstrated highly efficient intersystem crossing (ISC) from the excited singlet to triplet state. Herein, we designed a series of
The misuse and overuse of antibiotics result in the emergence resistant bacteria fungi, which make an urgent need new antimicrobial agents. Nowadays, peptides have attracted great attention researchers. However, low physiological stability biological system limits application naturally occurring as novel therapeutics. In present study, we synthesized derivatives protonectin by substituting all amino acid residues or cationic lysine residue with corresponding D-amino acids. Both D-enantiomer...