A5070021680- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Amino Acid Enzymes and Metabolism
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Enzyme Structure and Function
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Pharmacogenetics and Drug Metabolism
- Microbial Natural Products and Biosynthesis
- Analytical Chemistry and Chromatography
- Polyamine Metabolism and Applications
- Pancreatic function and diabetes
- Microbial Metabolites in Food Biotechnology
- Chemical Synthesis and Analysis
- Fungal Biology and Applications
- Peptidase Inhibition and Analysis
- Steroid Chemistry and Biochemistry
- Metabolism and Genetic Disorders
- Electrochemical sensors and biosensors
- Protein Hydrolysis and Bioactive Peptides
- Microbial metabolism and enzyme function
- Biochemical Acid Research Studies
- Diet, Metabolism, and Disease
- Neurological diseases and metabolism
Zhejiang University of Technology
2016-2025
Chemical Synthesis Lab
2025
Xingyi Normal University for Nationalities
2017-2025
Biocon (India)
2014-2025
Xiamen University
2023-2025
Industrial Technology Institute
2025
Guizhou University
2008-2024
Northwest A&F University
2024
Tan Kah Kee Innovation Laboratory
2023
Hangzhou Academy of Agricultural Sciences
2015-2020
Zinc (Zn) metal anodes suffer from the dendrite growth and hydrogen evolution reaction (HER) in classical aqueous electrolytes, which severely limit their lifespan. We propose a rational design of AgxZny protective coatings with selective binding to Zn2+ against H+ simultaneously regulate Zn pattern HER kinetics. further demonstrate that by tuning composition coating deposition behavior can be readily tuned conventional plating/stripping (on Zn-AgZn3 coating) alloying/dealloying Ag-AgZn...
Abstract Enzyme membrane reactors (EMRs) are becoming increasingly interesting for application in bioconversion processes food processing, pharmaceutics, biorefinery and wastewater treatment. Integrating the highly efficient enzymatic reaction with selectable separation technology, EMRs able to reduce product inhibition, improve stability of enzyme, increase number cycles sustainably separate products from biotransformation solutions. Generally, EMRs, enzymes can be either free solution,...
A novel magnetic hierarchically porous metal-organic framework (MOF) has been successfully fabricated via a modulator-induced defect-formation strategy. Amidase for the first time immobilized into this carrier and resultant bio-composite exhibits superior enzymatic catalysis performance compared to free enzyme its counterparts without hierarchical porosity.
Enzymatic synthesis of β-nicotinamide mononucleotide (NMN) from D-ribose has garnered widespread attention due to its cheap material, the use mild reaction conditions, and ability produce highly pure products with desired optical properties. However, overall NMN yield this method is impeded by low activity rate-limiting enzymes. The ribose-phosphate diphosphokinase (PRS) nicotinamide phosphoribosyltransferase (NAMPT), that control rate reaction, were engineered improve efficacy. actives...
Nicotinamide mononucleotide (NMN) has garnered substantial interest as a functional food product. Industrial NMN production relies on chemical methods, facing challenges in separation, purification, and regulatory complexities, leading to elevated prices. In contrast, biosynthesis through fermentation or enzyme catalysis offers notable benefits like eco-friendliness, recyclability, efficiency, positioning it primary avenue for future synthesis. Enzymatic synthesis encompasses the...
Abstract Carbonyl reductases are useful for producing optically active alcohols from their corresponding prochiral ketones. Herein, we applied a computer‐assisted strategy to increase the thermostability of previously constructed carbonyl reductase, Ls CR M4 (N101D/A117G/F147L/E145A), which showed an outstanding activity in synthesis ticagrelor precursor (1 S )‐2‐chloro‐1‐(3,4‐difluorophenyl)ethanol. The stability changes introduced by mutations at flexible sites were predicted using...
Ketopantoate hydroxymethyltransferase (KPHMT) plays a pivotal role in d-pantothenic acid biosynthesis. Most KPHMTs are homodecamers with low thermal stability, posing challenges for protein engineering and limiting output enhancement. Previously, high-enzyme activity KPHMT mutant (K25A/E189S) from Corynebacterium glutamicum was screened as mother strain (M0). Building upon this strain, our study focused on interface modifications, employing multifaceted approach including integrating...
The objective of this work is to investigate the effects reaction conditions on synthesis octenyl succinic anhydride (OSA)-modified starch from waxy corn and study characteristics OSA-modified as well its applications. A mathematical model was developed influences various processing condition factors production predict optimum conditions. maximal degree substitution (DS) (0.0204) predicted occur when concentration 31.2%, pH 8.6, temperature 33.6 degrees C, time 18.7 h. Repeated reactions for...