A5100420557- Immune cells in cancer
- Immune Cell Function and Interaction
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Mast cells and histamine
- Atherosclerosis and Cardiovascular Diseases
- Insect symbiosis and bacterial influences
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Food Allergy and Anaphylaxis Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Immune Response and Inflammation
- Viral Infections and Vectors
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Inflammasome and immune disorders
- Inflammatory mediators and NSAID effects
Hunan Academy of Traditional Chinese Medicine
2025
Liaocheng People's Hospital
2020-2024
Liaocheng University
2020-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Northwest A&F University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Chinese Academy of Sciences
2012-2023
The First People's Hospital of Changde
2023
Hefei Institutes of Physical Science
2023
Lasting activations of toll-like receptors (TLRs), MAPK and NF-κB pathways can support influenza A virus (IAV) infection promote pneumonia. In this study, we have investigated the effect mechanism action emodin on IAV using qRT-PCR, western blotting, ELISA, Nrf2 luciferase reporter, siRNA plaque inhibition assays. The results showed that could significantly inhibit (ST169, H1N1) replication, reduce IAV-induced expressions TLR2/3/4/7, MyD88 TRAF6, decrease phosphorylations p38/JNK nuclear...
Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. respond to different environmental factors thereby polarized into specialized functional subsets. Although hypoxia is an important factor, its impact on human macrophage polarization subsequent modification the inflammatory microenvironment have not been fully established. The present study aimed elucidate effect exposure ability macrophages polarize classically activated...
Summary C ucurbita moschata FLOWERING LOCUS T ‐ LIKE 2 (hereafter FTL 2) and A rabidopsis thaliana ( rabidopsis) FT ), components of the plant florigenic signaling system, move long‐distance through phloem from source leaves to vegetative apex where they mediate floral induction. The mechanisms involved in trafficking / remain be elucidated. In this study, we identified critical motifs on both required for cell‐to‐cell mutant analyses using a zucchini yellow mosaic virus expression vector....
Abstract Hepatocellular carcinoma (HCC) is a common high-mortality cancer, mainly due to diagnostic difficulties during its early clinical stages. In this study, we aimed identify genes that are important for HCC diagnosis and treatment, investigated the underlying mechanism of prognostic differences. Differentially expressed (DEGs) were identified by using limma package, receiver operating characteristic curve analysis was performed markers HCC. Bioinformatics specimens used assess...
Establishing a successful pregnancy depends on the endometrium and embryo. It is estimated that suboptimal endometrial receptivity account for one-third of implantation failures. Despite indepth understanding processes associated with embryo-endometrial cross-talk, little progress has been achieved diagnosis treatments receptivity.This retrospective study included women undergoing their first frozen-thawed embryo transfer (FET) cycles at our reproductive medicine center from March 2021 to...
The outbreak of white spot syndrome (WSS) is a looming challenge, due to dramatic losses the crustacean aquaculture industry. However, at present, there are no prophylactic or therapeutic means control this infectious viral disease. Here, we screened fifteen medicinal plants for their inhibitory activity on virus (WSSV), using red swamp crayfish (Procambarus clarkii) as model species. results showed that crude extracts Pinellia ternata (Thunb.) Breit. had highest effect (91.59%, 100 mg/kg)...
To explore the differentially expressed genes (DEGs) along with infiltrating immune cells landscape and their potential mechanisms in progression of atherosclerosis from onset to plaque rupture.In this study, three atherosclerosis-related microarray datasets were downloaded NCBI-GEO database. The gene set enrichment analysis (GSEA) was performed for interpreting biological insights expression data. CIBERSORTx algorithm applied infer relative proportions atherosclerotic samples. DEGs screened...
Previous studies have established a positive link between nurse managers' caring leadership and nurses' work engagement, but the processes conditions through which this style influences behaviors remain largely unexplored. To address gap contribute to existing body of knowledge, we developed chain-mediated effects model elucidate impact on engagement underlying mechanisms. In model, identified professional mission affective organizational commitment as mediating variables, offering novel...
Background: Pyroptosis is programmed cell death that induces anti-tumour immunity, inhibiting tumour growth. Oral squamous carcinoma (OSCC) a common malignant tumour, and promoting pyroptosis in OSCC can play tumour-killing role. Cucurbitacin B (CuB) natural compound extracted from many plants inhibits various tumours. However, whether CuB exert effects through has not been illuminated.Results: inhibited the proliferation of cells, induced increased levels inflammation factor supernatant;...
Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value epithelial ovarian cancer remains insufficiently investigated. A total 34 patients diagnosis (EOC), 15 benign (TB), 30 healthy volunteers (NOR) were enrolled this study. Fecal samples collected, followed by sequencing V3–V4 region 16S rRNA gene. The clinical data pathological characteristics comprehensively recorded for further...
Lymphogranuloma venereum (LGV) is a sexually transmitted disease (STD) caused by infection with invasive Chlamydia trachomatis serovars L1-L3 (1). LGV characterized inguinal and/or femoral lymphadenopathy, typically following transient, self-limited genital ulcer or papule that might go unnoticed. Rectal can result in proctocolitis present mucoid hemorrhagic rectal discharge, anal pain, constipation, fever, and tenesmus, signs of granulomas ulcerations on anoscopy (1,2). be an invasive,...
Intestinal microecology has been shown to participate in the pathogenesis of many diseases through different pathways, and intestinal premature infants is significantly from full-term infants. affected by various factors such as gestational age, diet, antibiotic use. However, there are few studies focus on effects diet microecological development This study explored formula milk (FM) breast (BM) for The results showed that BM feeding increases alpha diversity flora, however, FM contributes...
White spot syndrome virus (WSSV) is a major cause of disease in shrimp cultures worldwide. The infection process this large circular double-stranded DNA has been well studied, but its entry mechanism remains controversial. virion envelope protein VP28 implicated oral and systemic viral shrimp. However, genetic analysis shown the presence few genes related to proteins per os infectivity factor (PIF) complex baculoviruses. This essential for baculoviruses, terrestrial viruses, into midgut...
Human oral squamous cell carcinoma (OSCC) is the most common type of cancer and has a poor survival rate. Cell-cell communication between OSCC cells cancer-associated fibroblasts (CAFs) plays important roles in progression. We previously demonstrated that CAFs promote migration invasion. However, how influence proliferation unknown.