A5058136835- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Cancer-related gene regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- FOXO transcription factor regulation
- MicroRNA in disease regulation
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Microbial Natural Products and Biosynthesis
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Posttraumatic Stress Disorder Research
Hainan General Hospital
2019-2025
Hainan Medical University
2020-2024
Hainan Provincial Hospital of Traditional Chinese Medicine
2021
Hainan Medical College Hospital
2020
The First Affiliated Hospital, Sun Yat-sen University
2006
Sun Yat-sen University
2006
Abstract Hepatocellular carcinoma (HCC) is a common high-mortality cancer, mainly due to diagnostic difficulties during its early clinical stages. In this study, we aimed identify genes that are important for HCC diagnosis and treatment, investigated the underlying mechanism of prognostic differences. Differentially expressed (DEGs) were identified by using limma package, receiver operating characteristic curve analysis was performed markers HCC. Bioinformatics specimens used assess...
4092 Background: Hepatocellular carcinoma (HCC) is a significant health concern in China, and it has been leading cause of cancer-related deaths. Immunotherapy combined with anti-vascular growth therapy the first recommended therapy. In this study, we evaluated safety efficacy SCT-I10A (an anti-programmed death 1 [PD-1] monoclonal antibody) SCT510 (a bevacizumab biosimilar) compared to sorafenib as first-line treatment for advanced HCC. Methods: open-label, multicenter, phase 3 trial...
Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that HCC. However, the role homeobox A11 antisense (HOXA11-AS) determining HCC stem cell characteristics remains to be explained; hence, this study aimed investigate effects HOXA11-AS on characteristics. Initially, expression patterns and HOXA11 tissues, cells, cells were...
The significant response of immunotherapy is currently limited to a small number patients, which has high degree selectivity. Therefore, distinguishing the immune subtypes tumor necessary for patients who may benefit from checkpoint therapy. Clinical data and RNA expression Cancer Genome Atlas (TCGA) GENE EXPRESSION OMNIBUS (GEO) databases were used study relationship regulatory pathways with subtypes, effects on prognosis hepatocellular carcinoma (HCC) patients. Eight coding genes (ICGs)...
Abstract Histone methylation plays important roles in mediating the onset and progression of various cancers, lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene hepatocellular carcinoma (HCC). However, mechanism underlying its tumorigenesis remains undefined. Hence, we explored regulatory role KDM5B HCC cells, aiming identify novel therapeutic targets for HCC. Gene Expression Omnibus database StarBase were used predict pathways related Then,...
Examining the communications in tumor microenvironment (TME) specific to hepatocellular carcinoma (HCC), this exploration looks into role played by beta-1,4-Galactosyltransferase III (B4GALT3) bone marrow mesenchymal stromal cell-derived extracellular vesicles (BMSCs-EVs) regarding NF-κB pathway and triggering of cancer-associated fibroblasts (CAF). Through a multidisciplinary approach combining transcriptome sequencing, bioinformatic analysis, various experimental models, involvement...
SNHG3, a long noncoding RNA (lncRNA), has been linked to poor outcomes in patients with liver hepatocellular carcinoma (LIHC). In this study, we found that SNHG3 was overexpressed LIHC and associated LIHC. Functional assays, including colony formation, spheroid vivo assays showed promoted stemness of cancer stem cells (CSC) tumor growth by interacting microRNA-502-3p (miR-502-3p). miR-502-3p inhibitor repressed the tumor-suppressing effects depletion. Finally, pull-down, dual-luciferase...
Abstract Posttraumatic stress disorder (PTSD) is a psychiatric that plagues trauma survivors. Evidence shows brain‐derived neurotrophic factor (BDNF) may be involved in the occurrence and development of PTSD. Here we tried to demonstrate whether BDNF gene polymorphisms are correlated with neurocognitive function following PTSD patients hepatocellular carcinoma (HCC). This study included 102 HCC complicated PTSD, 146 patients, 152 healthy volunteers. Initially, evaluated subjects. Next,...
Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on clinical characteristics, treatment and prognosis of GBC Chinese population.The Research Group Cancer (CRGGC) study is multicentre retrospective registry cohort study. Clinically diagnosed patient with will be identified from 1 January 2008 to December, 2019, by reviewing electronic medical records 76 tertiary...
The aim of this study was to construct a model based on the prognostic features associated with epithelial-mesenchymal transition (EMT) explore various mechanisms and therapeutic strategies available for treatment metastasis invasion by hepatocellular carcinoma (HCC) cells.EMT-associated genes were identified, their molecular subtypes determined consistent clustering analysis. differentially expressed (DEGs) among ascertained using limma package they subjected functional enrichment immune...
Although extracellular vesicles (EVs) in body fluid have been considered to be ideal biomarkers for cancer diagnosis and prognosis, it is still difficult distinguish EVs derived from tumor tissue normal tissue. Therefore, the prognostic value of tumor-specific was evaluated through related molecules pancreatic NA sequencing data adenocarcinoma (PAAD) were acquired The Cancer Genome Atlas (TCGA) International Consortium (ICGC). EV-related genes obtained exoRBase. Protein-protein interaction...
Hepatocellular carcinoma (HCC) remains a life-threatening malignant tumor. Cancer stem cells (CSCs) harbor tumor-initiating capacity and can be used as therapeutic target for human malignancies. Bone morphogenetic proteins (BMPs) play regulatory role in CSCs. This study investigated the mechanism of BMP2 CSCs HCC.BMP2 expression HCC tissues cells, from HepG2 SMMC7721 (HepG2-CSCs SMMC7721-CSCs) was measured. The association between prognosis patients analyzed. were interfered with to evaluate...
Background: The immune microenvironment plays a vital role in the development of hepatocellular carcinoma (HCC). This study explored novel immune-related biomarkers to predict prognosis patients with HCC. Methods: RNA-Seq data were downloaded from Cancer Genome Atlas (TCGA). Univariate Cox regression was used identify prognosis-related genes; Lasso method construct risk model. Validation performed on International Consortium (ICGC) cohort, and C-index calculated evaluate its overall...
Background: The prognosis of patients with hepatocellular carcinoma (HCC) is negatively affected by the lack effective prognostic indicators. change tumor immune microenvironment promotes development HCC. This study explored new markers and predicted HCC systematically analyzing characteristic genes. Methods: Immune-related genes were obtained, differentially expressed (DEIGs) between para-cancer samples identified analyzed using gene expression profiles from TCGA, HCCDB, GEO databases. An...
To investigate the malignant potential of hepatic stem cells derived from bone marrow stromal (BMSCs) in a mouse model chemical hepatocarcino-genesis.BMSCs male BALB/c mice were harvested and cultured, then transplanted into female syngenic via portal vein. Hepato-carcinogenesis was induced by 6 months treatment with diethylnitrosamine (DEN). Six later, liver removed each treated evaluated immunohistochemistry fluorescence situ hybridization (FISH).Twenty-six percent recipient survived...
Abstract To study the impact of total splenectomy (TS) on peripheral lymphocytes and their subsets in patients with hypersplenism associated cirrhotic portal hypertension (CPH). We studied 102 consecutive who received TS from January 2008 to 2020 due CPH-related hypersplenism. A similar number healthy individuals are used as controls (HC). The lymphocyte counts percentages B lymphocytes, T (cluster differentiation (CD)3 + ) (CD4 , CD8 ), natural killer (NK) cells preoperative blood samples...
Pancreatic adenocarcinoma (PAAD) is a malignant tumor of the digestive system that associated with poor prognosis in patients owing to its rapid progression and high invasiveness. Ninety-seven invasive-related genes obtained from CancerSEA database were clustered obtain molecular subtype pancreatic cancer based on RNA-sequencing (RNA-seq) data The Cancer Genome Atlas (TCGA). differentially expressed (DEGs) between subtypes using limma package R, multi-gene risk model DEGs was constructed by...
cells with high repopulation capacity in the fiberized liver induced by DEN, which restores function and reduces fibrosis.