A5082981111- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- Air Quality and Health Impacts
- S100 Proteins and Annexins
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related gene regulation
- Natural Language Processing Techniques
- DNA Repair Mechanisms
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Cystic Fibrosis Research Advances
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Wnt/β-catenin signaling in development and cancer
Central South University
2014-2024
Hainan Medical University
2024
The First People's Hospital of Jiangxia District
2024
Huazhong University of Science and Technology
2024
He Eye Hospital
2023
Panyu District Central Hospital
2020
Hunan Institute of Science and Technology
2019
Hunter Medical Research Institute
2014-2016
Anshun University
2014
National Engineering Research Center of Human Stem Cells
2005-2008
Alzheimer' disease (AD), a progressive neurodegenerative characterized by impairments of cognitive function, is associated with inflammation which suggested to be potential cause synaptic deficits and neuronal loss. Apelin-13, predominant neuropeptide inhibiting effect on inflammation, has beneficial effects cognition memory damage. However, whether apelin-13 can protect neurons ameliorate AD inflammatory response the underling mechanism remains largely unknown. To test this hypothesis, rats...
Abstract Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets ROS, oxidative DNA modification is a major driving signal. However, role damage modulation profibrotic processes has not been fully delineated. Herein, we report that base lesions, 8-oxoG, complexed with 8-oxoguanine glycosylase 1 (OGG1) functions as pioneer factor, contributing to transcriptional reprogramming...
Human embryonic stem cells (hESCs) during long-term culture acquire chromosomal changes similar to those occurring in tumorigenesis. This was raised concerns about the progression from hESCs malignant cells. study aimed investigate chromosomes, cell phenotype, and genes culture-adapted ascertain whether tumorigenic transformation occurred. By cytogenetic analysis we found progressive karyotypic simple complex chHES-3, one of hESC lines established our laboratory, a suboptimal culture. We...
Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that HCC. However, the role homeobox A11 antisense (HOXA11-AS) determining HCC stem cell characteristics remains to be explained; hence, this study aimed investigate effects HOXA11-AS on characteristics. Initially, expression patterns and HOXA11 tissues, cells, cells were...
Aging is characterized by a progressive loss of physiological integrity, leading to impaired organ function and, ultimately, increased vulnerability death. Many complex diseases are related aging, including asthma. In the lung, airway epithelium serves as first barrier prevent access inspired external stimuli and dictates initial stress responses. Notably, in mucosa asthma patients, an increase senescent epithelial cells has been detected. Although it speculated that senescence could...
MicroRNAs (miRNAs) are short noncoding RNAs that regulate a broad spectrum of biological processes, including immune responses. Although the contributions miRNAs to function cells beginning emerge, their specific roles remain largely unknown. IL-33 plays an important role in macrophage activation for innate host defense and proinflammatory In this study, we report miR-487b can suppress levels mRNA protein during differentiation bone marrow-derived macrophages (BMDMs). This results inhibition...
Cervical cancer is a deadly disease. Some microRNAs are involved in tumor invasion and metastasis. Decreased expression of microRNA-199a has been correlated with tumorigenesis. In our study, the quantitative real-time polymerase chain reaction results indicated that was expressed at lower levels cervical tissues, level B7-H3 significantly increased compared adjacent normal tissues were inversely correlated. We also found downregulated cell lines when to immortalized cells. this identified as...
Abstract Our previous study indicated that adhesion molecule catenin alpha‐like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and animal model but little known about how the CTNNAL1 affects pathogenesis. To reveal direct relationship between CTNNAL1, CTNNAL1‐deficient mouse bronchopulmonary tissue was constructed by introducing CTNNAL1‐siRNA sequence using adeno‐associated virus (AAV) as vector. The established stimulation house dust mite (HDM). After...
Airway epithelial cells play a significant role in the pathogenesis of asthma. Although structural and functional defects airway have been postulated to increase asthma susceptibility exacerbate severity, mechanism implication these remain uncertain. Integrin β4 (ITGB4) is adhesion molecule that downregulated epithelium patients. In this study, we demonstrated ITGB4 deficiency leads severe allergy-induced inflammation hyper-responsiveness (AHR) mice. After house dust mite (HDM) challenge,...
SNHG3, a long noncoding RNA (lncRNA), has been linked to poor outcomes in patients with liver hepatocellular carcinoma (LIHC). In this study, we found that SNHG3 was overexpressed LIHC and associated LIHC. Functional assays, including colony formation, spheroid vivo assays showed promoted stemness of cancer stem cells (CSC) tumor growth by interacting microRNA-502-3p (miR-502-3p). miR-502-3p inhibitor repressed the tumor-suppressing effects depletion. Finally, pull-down, dual-luciferase...
The shedding of airway epithelial cells and loss functional homeostasis are major pathological characteristics asthma; however, the mechanism underlying these pathologies remains obscure. Our previous work showed that there were three variation sites in 5' flanking region integrin beta4 asthma patients, which was correlated with decreased expression peripheral leukocytes. Integrin is an important structural adhesion molecule on epithelia to keep cells. In this work, we further demonstrated...
Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, direct relevance between BD-like psychiatric is almost unknown. Integrin β4 (ITGB4) downregulated on epithelial patients, which might play a critical role in parthenogenesis inflammation. So this study aimed to examine ITGB4 deficiency mediating further leading behaviors. ITGB4−/− mice were generated by mating ITGB4fl/fl CCSP–rtTAtg/−/TetO-Cretg/tg mice. Mania-like...
Persistent injury and the following improper repair in bronchial epithelial cells are involved pathogenesis of airway inflammation remodeling asthma. E-cadherin (ECAD) has been shown to be epithelium repair, but its underlying mechanisms this process is poorly understood. Here, we describe a previously undetected function ECAD regulating balance EMT MET during repair. Injury mice human (HBECs) was induced by successive ozone stress for 4 days at 30 min per day. overexpression HBECs stable...
Background:In airway disease such as asthma a hyperactive cellular event of epithelial-mesenchymal transition (EMT) is considered the mechanism pathological tissue remodeling after injury to epithelium.And initiation EMT in airways depends on epithelial disruption involving dissolution and/or destabilization adhesive structures between cells and ECM.Previously, we have shown that integrin-β4, an adhesion molecule bronchial epithelium important regulator cell proliferation wound repair human...
A complex network of regulatory neuropeptides controls airway inflammation reaction, in which epithelial cells adhering to and activating leukocytes is a critical step. To study the effect intrapulmonary peptides on adhesion polymorphonuclear (PMNs) bronchial (BECs) its mechanism, several including vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1) calcitonin gene-related (CGRP), were investigated. The results demonstrated that VIP EGF showed inhibitory...
Airway epithelial cells have been demonstrated to be accessory antigen presentation (APC) capable of activating T and may play an important role in the development allergic airway inflammation asthma. In asthmatic airways, loss expression adhesion molecule integrin β4 (ITGB4) increase Th2 bias has observed our previous study. Given that ITGB4 is engaged multiple signaling pathways, we studied whether disruption ITGB4-mediated cell contribute adaptive immune response cells, including their...