To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α levels in posttraumatic stress disorder (PTSD) patients.We utilized ELISA technology to examine cytokines such as from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, age- gender-matched healthy controls. We conservatively employed Mann-Whitney U testing.Individuals had significantly elevated peripheral cytokine for all 6 different compared controls (all P<0.01).These findings suggest that generalized...

Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that HCC. However, the role homeobox A11 antisense (HOXA11-AS) determining HCC stem cell characteristics remains to be explained; hence, this study aimed investigate effects HOXA11-AS on characteristics. Initially, expression patterns and HOXA11 tissues, cells, cells were...

Abstract Posttraumatic stress disorder (PTSD) is a psychiatric that plagues trauma survivors. Evidence shows brain‐derived neurotrophic factor (BDNF) may be involved in the occurrence and development of PTSD. Here we tried to demonstrate whether BDNF gene polymorphisms are correlated with neurocognitive function following PTSD patients hepatocellular carcinoma (HCC). This study included 102 HCC complicated PTSD, 146 patients, 152 healthy volunteers. Initially, evaluated subjects. Next,...

Cervical cancer is the second deadliest gynecologic malignancy, characterized by apparently precancerous lesions and cervical intraepithelial neoplasia (CIN), having a long course from development of CIN to cancer. Cyclin-dependent kinase inhibitor 2A (CDKN2A) well-documented tumor suppressor gene commonly methylated in However, relationship between CDKN2A carcinogenesis inconsistent, diagnostic accuracy underinvestigated. In this study, we attempted quantify association methylation cancer,...

To investigate residents' psychological stress factors and research the correlation between post-traumatic disorder (PTSD) platelet 5-HT concentrations so as to provide scientific bases for diagnosis treatment of PTSD intervention people in disaster area.A questionnaire survey 5500 residents who have accepted help was conducted by emphatic investigation method. While high performance liquid chromatography used detect serotonin concentration 100 patients healthy people.(1) Of 5114 cases, 3167...

To evaluate the clinical effects of comprehensive therapy psychological intervention and rehabilitation training on mental health patients with acute stroke. A total 120 stroke were randomly divided into trial group control group. Both groups given corresponding drug therapy, medical basic nursing convention nursing. Besides, added to SCL-90, Europ scales (ESS) score assessed each patient day 3 for first time 21 second time; Barthel index was 90. After intervention, SCL-90 declined...

Objective To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods A total 300 patients sporadic PTSD and 150 healthy subjects (the control group) were selected according to diagnostic criteria (DSM-IV), genotypes BDNF SNPs G-712A, C270T, rs6265, rs7103411 detected by polymerase chain reaction direct DNA sequencing determine intergroup differences in allele frequencies; p...

To explore the characteristics of metabolic changes in patients with post-traumatic stress disorder through 1H-MRS neuroanatomical circuit comparing age-matches controls.Fifty and 50 gender-and age-matched normal controls were involved. The neurochemical abnormalities including levels choline (Cho)/creatine(Cr) N-acetylaspartate (NAA)/Cr measured respectively hippocampus anterior cingulate gyrus three-dimension 1H-proton spectroscopy(3D 1H-MRS).The values NAA/Cr ratios significant lower...

To evaluate the clinical effects of psychological interventions and drug therapy against peptic ulcer. 96 patients with ulcer were divided into control group Tagamet 800 mg per evening p.o. trial intervention on basis treatment. There significant differences between two groups (P<0.05), showed that anxiety depression cases declined obviously effective rate was much higher than group. In sum, combined provides an method for

Background Cancer patients with posttraumatic stress disorder can lead to their noncompliant behaviors. However, less is known about the neurocognitive functioning of in general cancer types or patient populations. The current study attempted examine prevalence and relationships executive function individuals cancer. Methods A total 285 150 healthy were recruited for present study. Clinician Administered PTSD Scale, Tower Hanoi, Wisconsin Card Sorting Test, Wechsler Adult Intelligence...

SUMMARY OBJECTIVE To explore the association of brain-derived neurotrophic factor gene (BDNF) polymorphism with latent cognitive endophenotype posttraumatic stress disorder (PTSD) after major natural disasters in Hainan Province, China. METHODS A total 300 patients PTSD and 150 healthy controls (HC) were surveyed by psychoanalysis scale to assess their functions. Polymerase chain reaction (PCR) polyacrylamide gel electrophoresis (PAGE) used detect BDNF polymorphism. RESULTS In terms...

Objective: To investigate the occurrence of PTSD in pre-hospital emergency nurses and its related factors, to compare differences neurotransmitter immune-related factors between who experienced traumatic events those did not develop healthy people. How: Post-traumatic Stress Disorder Self-Rating Scale (PCL-C) tests were performed on group, non-PTSD group control plasma monoamine neurotransmitters serum cytokines determined by double-antibody sandwich ABC-ELISA assay using enzyme-linked...

Abstract The necroptosis mediated by RIPK3 is stringently regulated for intestinal homeostasis. Here we found that mice lacking Prmt5 (Protein arginase methyltransferase 5) in epithelial cells (IECs) caused premature death with IECs necroptosis, villus atrophy and loss of Paneth cells. This pathology can be partially rescued antibiotic treatment, germ-free breeding condition pharmaceutical inhibition RIPK1 RIPK3, but aggravated embryonic lethality Caspase -8 deficiency, which demonstrating...

Background: To explore the relevant risk factors of poor prognosis in patients with sudden sensorineural hearing loss (SSNHL), constructing prognostic prediction model, formulating effective treatment strategies, and providing reliable theoretical basis for clinical prevention SSNHL. Methods: A retrospective analysis was conducted on data 123 SSNHL who received at Zhongxian People’s Hospital Chongqing from March 2022 to 2024. According prognosis, they were divided into an group (68 cases...

Objective: To investigate the effects of cognitive behavioral intervention on psychological stress response in breast cancer patients by patients. Methods: Adopting random comparison method, 100 with were divided into group and 50 cases. The underwent at same time as only received conventional treatment without intervention. Two groups enrolled general questionnaire, Self-Rating Anxiety Scale (SAS), Medical Coping Modes Questionnaire (MCMQ) within one week after admission month to understand...

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Abstract The objective of this study was to investigate the effects ultrasound‐guided injection ultrasound contrast agents (UCAs) and p53 gene on treatment rats with breast cancer (BC). Assembly expression vector as well that a rat model BC consisted 200 successfully modeled randomly divided into 5 groups: introduction, introduction + irradiation, UCAs, UCA irradiation groups. Expression detected via quantitative real‐time polymerase chain reaction (qRT‐PCR), western blotting...

Objective: To study the association between post-traumatic stress disorder (PTSD) and serotonin transporter promoter (5-HTTLPR) gene polymorphism in Han children Hainan; to explore genetic mechanism of PTSD children. Methods: 50 patients with healthy nationality Hainan were selected. Detection 5-HTTLPR by polymerase chain reaction (PCR) amplified fragment length polymorphism, genotype allele frequencies analyzed using a case-control analysis method. Results: There 4, 14 32 cases LL, SL SS...

Studies have shown that the expression level of brain-derived neurotrophic factor (also known as BDNF) is great significance on neutron activity, which has a close relationship with improvement learning and memory ability; it effect physical growth development an individual well. On other hand, childhood autism group serious neurodevelopmental disorders. Some literature pointed out BDNF plays tremendously important role in pathogenesis treatment neuropsychiatric diseases. In recent years,...

Objective: To investigate the correlation between 5-HTTLPR (5-and serotonin transporter linked polymer region) gene polymorphism and BDNF (brain derived neural factor) PTSD (post traumatic stress disorders) in Li Han nationalities Hainan Province. Methods: 167 patients, 141 patients 158 healthy volunteers (control group) were investigated by ETI, caps, Toh, WCST, TMT WAIS-RC. The polymorphisms of rs6265 locus genes detected PCR (polymerase chain reaction) page (polycylamide gel...

Enhanced recovery after surgery (ERAS), a series of evidence-based optimization measures during the perioperative period, to reduce patients’ physical and psychological traumatic stress responses, complications, shorten length hospital stay, risk readmission mortality, ultimately promote rapid patient resuscitation, is adopted. The negative emotional experience patients may aggravate surgical response, interfere with endocrine system nervous system, cause imbalance internal environment, have...

Objective To build the access standard and role function of cancer case manager which is suitable for China. Methods The draft indicators were formulated based on literature review, group discussion Delphi method. All appraised by using two-round method. Results Round 1 consulting experts 43, round 2 41. The showed high degree during two rounds expert advice (two advisory Kendall coordination coefficients 0.300, 0.358 0.375, 0.358, P < 0.01). included 4 first-level 34 secondary...

Objective To investigate the relationship between levels of psychological resilience and coping styles patients with recurrence nasopharyngeal neoplasms during hospitalization, in order to provide scientific data about clinical intervention. Methods A total 240 cases hospitalized were selected measured general information questionnaire which was self-designed, scale (CD-RISC) scale. Results Resilience average score recurrent (53.22 ± 12.09) points, level positively correlated...