A5101408993- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Toxoplasma gondii Research Studies
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Alzheimer's disease research and treatments
- Histone Deacetylase Inhibitors Research
- Ginkgo biloba and Cashew Applications
- Ferroptosis and cancer prognosis
- Biological and pharmacological studies of plants
- Cancer Genomics and Diagnostics
- Cardiac and Coronary Surgery Techniques
- TGF-β signaling in diseases
- Virus-based gene therapy research
- Inflammasome and immune disorders
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- Advanced Sensor and Control Systems
- Nuclear Receptors and Signaling
Shanxi Medical University
2013-2025
The Fourth People's Hospital
2024
Guiyang Medical University
2022-2024
Haikou City People's Hospital
2024
Jiangxi University of Traditional Chinese Medicine
2024
Wenzhou City People's Hospital
2017-2023
People's Hospital of Xinjiang Uygur Autonomous Region
2023
Hainan General Hospital
2010-2021
Hainan Medical University
2021
China Medical University
2006-2020
Alzheimer's disease is characterized by abnormal β-amyloid and tau accumulation, mitochondrial dysfunction, oxidative stress, synaptic dysfunction. Here, we aimed to assess the mechanisms signalling pathways in neuroprotective effect of gastrodin, a phenolic glycoside, on murine neuroblastoma N2a cells expressing human Swedish mutant APP (N2a/APP). We found that gastrodin increased levels presynaptic-SNAP, synaptophysin, postsynaptic-PSD95 reduced phospho-tau Ser396, Aβ
Colorectal cancer (CRC) is the third leading cause of cancer-related death in western world. In this study, we evaluated expression matrix metalloproteinase 2 gene (MMP2) CRC and analyzed its correlation with clinicopathological features. We found that MMP2 was significantly higher tissues than colorectal tissues. addition, high levels protein were positively correlated status tumor size, lymph node metastasis, distant Dukes' stage, invasion. Moreover, patients had markedly shorter overall...
Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that HCC. However, the role homeobox A11 antisense (HOXA11-AS) determining HCC stem cell characteristics remains to be explained; hence, this study aimed investigate effects HOXA11-AS on characteristics. Initially, expression patterns and HOXA11 tissues, cells, cells were...
Abstract Background Peritoneal metastasis (PM) is an important pathological process in the progression of gastric cancer (GC). The metastatic potential tumor and stromal cells governed by hypoxia, which a key molecular feature microenvironment. Mesothelial also participate this complex dynamic process. However, mechanisms underlying hypoxia-driven mesothelial-tumor interactions that promote peritoneal GC remain unclear. Methods We determined hypoxic microenvironment PM nude mice...
A previous study reported that LINC00261 is significantly downregulated in human ectopic endometrial tissues. The present aimed to explore whether functional endometriosis cell proliferation, apoptosis and migration.By transfecting line CRL-7566 with plasmids containing LINC00261, we successfully established the CRL-7566/LINC00261 a high expression level. Cell-counting kit-8 colony formation assays were conducted evaluate effect of on flow cytometry analysis transwell migration assay its...
Abstract Histone methylation plays important roles in mediating the onset and progression of various cancers, lysine‐specific demethylase 5B (KDM5B), as a histone demethylase, is reported to be an oncogene hepatocellular carcinoma (HCC). However, mechanism underlying its tumorigenesis remains undefined. Hence, we explored regulatory role KDM5B HCC cells, aiming identify novel therapeutic targets for HCC. Gene Expression Omnibus database StarBase were used predict pathways related Then,...
Two classical models have been proposed for the development of colorectal cancer (CRC) from colon epithelial cells. The first model described process transformation adenoma to cancer, and other, serrated polyps cancer. However, clinical data showed that there is still a certain amount CRC not derived above two pathways, forming theoretical island pathogenesis. Laterally spreading tumor (LST) special digestive tract tumor, an important precancerous lesion CRC. Pathologically, LST has...
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a widespread lung marked by alveolar wall damage, leading to inflammation and fibrosis. Key risk factors include age, smoking, sex, education, with smoking being the most crucial. These are globally consistent linked aging. Club cell secretory protein 16 (CC16), primarily secreted non‐ciliated bronchial epithelial cells, crucial for health, offering anti‐inflammatory antioxidant benefits. CC16 levels notably reduced in COPD, suggesting...
Toxoplasma gondii is a ubiquitous protozoan parasite that can infect all warm-blooded animals, including both mammals and birds. Protein disulfide isomerase (PDI) localises to the surface of T. tachyzoites modulates interactions between host cells. In this study, protective efficacy recombinant PDI (rTgPDI) as vaccine candidate against infection in BALB/c mice was evaluated. rTgPDI expressed purified from Escherichia coli. Five groups animals (10 animals/group) were immunised with 10, 20,...
Accumulating evidence indicates that Clara cell protein-16 (CC16) has anti-inflammatory functions, although the involved molecular pathways have not been completely elucidated. Here, we evaluated effect of recombinant rat CC16 (rCC16) on expression tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and IL-8 in lipopolysaccharide (LPS)-stimulated mouse macrophages (RAW264.7 cells) explored underlying mechanisms. It was found rCC16 inhibited LPS-induced TNF-α, IL-6, at both messenger...
Abstract Hepatocellular carcinoma (HCC) occurs mainly in patients with chronic liver disease and cirrhosis. Increasing evidence has identified the involvement of microRNAs (miRNAs) acting as essential regulators progression HCC. As predicted by microarray analysis, miR‐448 might potentially affect HCC regulating melanoma‐associated antigen (MAGEA). Therefore, present investigation focused on exploring whether or not MAGEA6 were involved self‐renewal stemness maintenance stem cells. The...
Abstract Background Bladder cancer (BCa) is a common malignancy characterized by high heterogeneity, yet the current treatment modalities are limited. The aim of present investigation was to unravel functional role Karyopherin alpha 2 (KPNA2), tumor facilitator identified in multiple malignancies, progression BCa. Methods BCa tissues and adjacent normal were surgically resected analyzed from patients with determine expression profile KPNA2 Chromobox 8 (CBX8) RT-qPCR, Western blot analysis...
Esophageal squamous cell carcinoma (ESCC) demonstrates high genome instability. Here, we analyze 528 whole genomes to investigate structural variations' mechanisms and biological functions. SVs show multi-mode distributions in size, indicating distinct mutational processes. We develop a tool define five types of complex rearrangements with templated insertions. highlight type fold-back inversion, which is associated poor outcomes. Distinct rearrangement signatures demonstrate variable...
Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, regulates multiple biologic and pathologic processes including mitosis, genomic integrity, cell homeostasis tumorigenesis. However, the role of SIRT2 in immune response to cancer remains largely elusive. In this study, we found significantly lower expression peripheral T lymphocytes from breast patients when compared normal individuals. Moreover, levels positively correlated with CD8+ effector memory (TEM) cells patients. keeping these...
The ankyrin repeat domain 49 (ANKRD49) is an evolutionarily conserved protein highly expressed in testes. However, the function of ANKRD49 spermatogenesis unknown. In this study, we found that resides primarily nucleus spermatogonia, spermatocytes and round spermatids. overexpression augments starvation-induced autophagy male germ GC-1 cells whereas shRNA knockdown attenuates autophagy. Inhibition NF-κB pathway by its inhibitors or p65 siRNA prevents ANKRD49-dependent augmentation,...
Hepatocellular carcinoma (HCC) remains a life-threatening malignant tumor. Cancer stem cells (CSCs) harbor tumor-initiating capacity and can be used as therapeutic target for human malignancies. Bone morphogenetic proteins (BMPs) play regulatory role in CSCs. This study investigated the mechanism of BMP2 CSCs HCC.BMP2 expression HCC tissues cells, from HepG2 SMMC7721 (HepG2-CSCs SMMC7721-CSCs) was measured. The association between prognosis patients analyzed. were interfered with to evaluate...
ABSTRACT Abnormal amyloid-β (Aβ) abnormal accumulation and oxidative stress play important roles in Alzheimer’s disease (AD). Quercetin has been reported to possess antioxidant anti-inflammatory properties, thus of therapeutic interests for neurodegenerative disorders. In the present study, we aimed characterize mechanisms by which quercetin exerts neuroprotective effects murine neuroblastoma N2a cells stably expressing human Swedishh mutant amyloid precursor protein (APP). treatment...
This study aimed at comparing sacrospinous ligament fixation (SSLF) with uterosacral and cardinal (USCLF) concerning complications outcomes in patients pelvic organ prolapse (POP).A retrospective analysis was performed on the clinical data of POP stage III or above uterine treated Wenzhou People's Hospital from January 2013 to December 2019. Patients were divided into two groups: USCLF group SSLF group. The perioperative indicators, postoperative complications, quantification (POP-Q), Pelvic...
Abstract We investigated the somatic mutations and key driving factors of cervical cancer by whole exome sequencing . found 22,183 single nucleotide variations (SNVs) in 52 paired samples. Somatic SNVs were significantly higher than those high-grade intraepithelial lesion low-grade squamous groups ( P < 0.05). C → T/G accounted for 44.12% base substitution. Copy number variation (false discovery rate 0.05) was 57 chromosome regions. The three regions with significant differences between...
The apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908) secretes a group of serine/threonine kinases from rhoptries, which play vital roles in boosting intracellular infection.Toxoplasma rhoptry organelle protein 17 (ROP17) is one these important kinase proteins.Nevertheless, its function remains unclear.Here, we showed that ROP17 induced autophagy vitro and vivo.The small intestine tissues T. tachyzoite (RH strain)-infected mice was detected by the immunohistochemistry staining LC3B,...