A5008384639- Signaling Pathways in Disease
- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- Enzyme Production and Characterization
- Sexual Differentiation and Disorders
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- FOXO transcription factor regulation
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Sperm and Testicular Function
- Actinomycetales infections and treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Hormonal and reproductive studies
- Protease and Inhibitor Mechanisms
- Microbial Community Ecology and Physiology
- Cellular Mechanics and Interactions
- Mycobacterium research and diagnosis
Shanxi Medical University
2017-2025
Kunming University
2023-2024
Background/Objectives: Long noncoding RNAs (lncRNAs) participate in the occurrence and development of non-small-cell lung carcinoma (NSCLC). But for certain lncRNAs, their effects on NSCLC remain unclear. This work discovered that lncRNA RP11-297P16.4 is elevated NSCLC. Methods: LncRNA expression within LUAD tissues cells was measured through RT-qPCR Western blot. To assess role NSCLC, gain- or loss-of-function experiments were conducted using an mouse tumor model. Results: Silencing...
ABSTRACT Chronic obstructive pulmonary disease (COPD) is a widespread lung marked by alveolar wall damage, leading to inflammation and fibrosis. Key risk factors include age, smoking, sex, education, with smoking being the most crucial. These are globally consistent linked aging. Club cell secretory protein 16 (CC16), primarily secreted non‐ciliated bronchial epithelial cells, crucial for health, offering anti‐inflammatory antioxidant benefits. CC16 levels notably reduced in COPD, suggesting...
A Gram-positive, acid-fast, aerobic, rapidly growing and non-motile strain was isolated from lead–zinc mine tailing sampled in Lanping, Yunnan province, Southwest China. 16S rRNA gene sequence analysis showed that the most closely related species of KC 300 T Mycolicibacterium litorale CGMCC 4.5724 (98.47 %). Additionally, phylogenomic specific conserved signature indel revealed should be a member genus , Mycobacterium palauense CECT 8779 grossiae DSM 104744 also members . The genome size 6.2...
Lung adenocarcinoma (LUAD) is the most challenging neoplasm to treat in clinical practice. Ankyrin repeat domain 49 protein (ANKRD49) highly expressed several carcinomas; however, its pattern of expression and role LUAD are not known. Tissue microarrays, immunohistochemistry, χ2 test, Spearman correlation analysis, Kaplan-Meier, log-rank Cox's proportional hazard model were used analyse cases. The effect ANKRD49 on was investigated using CCK-8, clonal formation, would healing, transwell...
Previous studies demonstrated that herpes simplex virus thymidine kinase (HSVtk) could phosphorylate non‑toxic gancyclovir (GCV) efficiently to produce phosphorylated products result in cell apoptosis, kill tumor cells. The present study aimed construct a plasmid vector, pcDNA3.1‑pAFP‑TK, carrying the suicide gene driven by alpha‑fetoprotein (AFP) promoter, investigate cytotoxicity of HSVtk/GCV system on hepatoma carcinoma Reverse transcription‑polymerase chain reaction and western blotting...
Ankyrin repeat domain 49 (ANKRD49) has been found to be highly expressed in multiple cancer including lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC). However, the function of ANKRD49 pathogenesis NSCLC still remains elusive. Previously, demonstrated promote invasion metastasis A549 cells, a LUAD cell line, via activating p38-ATF-2-MMP2/MMP9 pathways. Considering heterogeneity tumor mechanism need more NSCLC-originated cells clarify.Real-time qPCR was employed test expression levels...
Background: It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this change remains elusive.Methods: The expression patterns Fancd2 opposite-strand (Fancd2os) BALB/c male mice and testicular tissue derived cell lines (GC-1, GC-2, TM3, TM4) were assessed using real-time polymerase chain reaction (RT-PCR), Western blot immunofluorescence. Fancd2os-overexpressing or knockdown TM3 cells constructed by infecting them lentivirus particles used...
Abstract Ankyrin repeat domain 49 (ANKRD49) has been found to highly expressed in multiple cancer including lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC). However, the function of ANKRD49 pathogenesis NSCLC still remains elusive. Previously, demonstrated promote invasion metastasis A549 cells, a LUAD cell line, via activating p38-ATF-2-MMP2/MMP9 pathways. Considering heterogeneity tumor mechanism need more NSCLC-originated cells clarify. We that promoted migration NCI-H1299...
Strain KC 927 T was isolated during an investigation of the soil bacteria diversity on Jiaozi Mountain, central Yunnan, Southwest China. The strain Gram-stain-negative, rod-shaped, non-motile, oxidase-negative, catalase-positive and aerobic. Results 16S rRNA gene alignment phylogenetic analysis indicated that a member genus Chryseobacterium closely related to caseinilyticum GCR10 (98.4%), piscicola DSM 21068 (98.3 %) ‘ formosus ’ CCTCC AB 2015118 (97.9 %). With genome size 4 348 708 bp, had...