A5020376217- Microbial Natural Products and Biosynthesis
- Cardiac electrophysiology and arrhythmias
- Analytical Chemistry and Chromatography
- Fungal Biology and Applications
- Gastroesophageal reflux and treatments
- Cardiac Ischemia and Reperfusion
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Residue Analysis and Safety
- Genomics and Phylogenetic Studies
- Lipid metabolism and disorders
- Hydrocarbon exploration and reservoir analysis
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Esophagitis
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Mycorrhizal Fungi and Plant Interactions
- Reproductive Biology and Fertility
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience and Neuropharmacology Research
Guangxi Medical University
2020-2025
Nanjing Medical University
2015-2024
Kunming University
2022-2024
Yunnan University
2013-2024
Zhongda Hospital Southeast University
2024
Southeast University
2024
Shanghai University of Sport
2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021-2023
The study aims to investigate the demographic characteristics, variations in their immune status, and mortality risk among HIV-1 infection long-term non-progressors (LTNP). Eligible LTNP typical progressors (TP) were recruited Guangxi by December 2018. Participants followed up until 2022, monitoring ART CD4+ T cell counts, survival/death outcomes. Multivariate logistic, Cox regression, Kaplan-Meier method employed scrutinize associated factors of LTNP. A total 212 390 TP included. cohort...
The JAK/STAT signal transduction pathway controls numerous events in Drosophila melanogaster development. Receptors for the have yet to be identified. Here we identified a gene that shows embryonic mutant phenotypes identical those hopscotch (hop)/JAK kinase and marelle (mrl)/Stat92e mutations. We named this master of (mom). Genetic analyses place mom's function between upd (the ligand) hop. further show cultured cells transfected with mom bind UPD activate HOP/STAT92E pathway. encodes...
1. In the present study, we tested hypothesis that long‐term administration of hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor simvastatin may regress hypertrophy and possible effect on angiotensin‐converting enzyme (ACE) activity in rats with pressure‐overload cardiac hypertrophy. 2. Pressure‐overload left ventricular (LVH) was induced by part coarctation abdominal aorta; a sham‐operated group served as control. Six weeks after operation, animals were divided into three...
Seven new 3,4,6-trisubstituted α-pyrone derivatives, violapyrones A–G (1–7), were isolated from Streptomyces violascens obtained Hylobates hoolock feces. Their structures elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities 1–7 evaluated against Gram-positive and Gram-negative bacteria fungi. Compounds 1–3 showed moderate antibacterial Bacillus subtilis Staphylococcus aureus with MIC values 4–32 μg/mL.
// Jiayu Li 1 , Xuefei 2 Shengxiang Ren Xiaoxia Chen Yishi Zhang Fei Zhou Mingchuan Zhao Chao Xiu 3 Ningning Cheng Yinmin 4 Caicun Fred R. Hirsch 5 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School Medicine, Cancer Institute, Shanghai, China Lung and Immunology, University, Respiration, Zaozhuang Municipal Zaozhuang, Shandong, Central Laboratory, Departments Medicine Pathology, Colorado Center, Aurora, Colorado, USA. Correspondence to: Dr. Zhou, e-mail:...
From a fermentation broth of Streptomyces albolongus obtained from Elephas maximus feces, nine bafilomycins (1–9) and seven odoriferous sesquiterpenoids (10–16) were isolated. The structures the new compounds, including three bafilomycins, 19-methoxybafilomycin C1 amide (1), 21-deoxybafilomycin A1 (2), A2 (3), two sesquiterpenoid degradation products, (1β,4β,4aβ,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (10) (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol...
1. Oxidative mechanisms have been implicated in neonatal cardiomyocyte hypertrophy. We and others shown that a HMG-CoA reductase inhibitor preserves endogenous antioxidant enzyme activity inhibits cardiac hypertrophy vivo. therefore examined whether noradrenaline (NA) induces the generation of reactive oxygen species (ROS) during its induction simvastatin, inhibitor, attenuates ROS production thus NA-induced cardiomyocytes. 2. NA increased intracellular levels concentration-dependent manner....
A mechanochemical-assisted extraction (MCAE) method was proposed and investigated for the fast of two kaempferol glycosides (kaempferol-3-O-[2-O-β-d-galactopyranosyl-6-O-α-l-rhamnopyranosyl]-β-d-glucopyranoside kaempferol-3-O-[2-O-β-d-xylopyranosyl-6-O-α-l-rhamnopyranosyl]-β-d-glucopyranoside) from Camellia oleifera Abel. meal. The effects operating parameters in terms NaOH content, grinding time, ratio solution to solid were evaluated by means response surface methodology (RSM). Under...
Abstract The enantioselective degradation behavior of the chiral insecticide dinotefuran in cucumber and soil was investigated under greenhouse conditions based on method established with a normal‐phase high‐performance chromatography (HPLC) ChromegaChiral CCA column (250 × 4.6 mm, 5 µm, ES Industries). linearity range, matrix effect, precision, accuracy were evaluated then successfully applied for analysis soil. Significant enantioselectivity observed according to results. (+)‐dinotefuran...
ABSTRACT Chiral pesticide enantiomers often show different bioactivity and toxicity; however, this property is usually ignored when evaluating their environmental public health risks. Hexaconazole a chiral fungicide used on variety of crops for the control many fungal diseases. This use provides opportunities pollution food soil. In study, sensitive convenient liquid chromatography coupled with tandem mass spectrometry (LC‐MS/MS) method was developed validated measuring hexaconazole in...
Six new fusicoccane-type diterpenoids (2–7) were isolated from the fermentation broth of Streptomyces violascens, which was Ailuropoda melanoleuca (giant panda) feces. The structures these compounds elucidated by a detailed spectroscopic data and X-ray crystallographic analysis. Compounds 5–7 demonstrated cytotoxicity against five human cancer cell lines, with IC50 values ranging 3.5 ± 0.7 to 14.1 0.8 μM. Cell adhesion, migration, invasion assays showed that 6 inhibited migration...