A5101680750- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Signaling Pathways in Disease
- Hedgehog Signaling Pathway Studies
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Cardiovascular Function and Risk Factors
- Biochemical Analysis and Sensing Techniques
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Birth, Development, and Health
- Calcium signaling and nucleotide metabolism
- Wound Healing and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Chromatin Remodeling and Cancer
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
Ministry of Agriculture and Rural Affairs
2023-2024
South China Agricultural University
2023-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024
Hangzhou Red Cross Hospital
2024
Ji Hua Laboratory
2023
Guangzhou Medical University
2013-2022
State Key Laboratory of Respiratory Disease
2020-2022
Second Affiliated Hospital of Guangzhou Medical University
2010-2021
Xiaomi (China)
2021
Shanghai Jian Qiao University
2017
Obesity is a major risk factor for the development of cardiovascular disease. Emerging evidence indicates that leptin, protein encoded by obesity gene, linked with cardiac hypertrophy in obese humans and directly induces cardiomyocyte vitro. However, mechanisms which leptin are poorly understood.This study investigated how contributes to hypertrophy. Cultured neonatal rat cardiomyocytes were used evaluate effects on Both endothelin-1 (ET-1) reactive oxygen species (ROS) levels elevated...
Background— Nitric oxide (NO) deficiency contributes to diabetic wound healing impairment. The present study tested the hypothesis that increased cutaneous superoxide (O 2 − ) levels in type 1 mice cause NO and delayed healing. Methods Results— Wound was markedly streptozotocin-induced compared with normal controls. There were significantly reduced of endothelial synthase (eNOS) protein constitutive NOS activity wounds, whereas O increased. A single regimen gene therapy eNOS or manganese...
Objective Autophagy is activated in ischemic heart diseases, but its dynamics and functional roles remain unclear controversial. In this study, we investigated the role of autophagy mechanism(s), if any, during postinfarction cardiac remodeling. Methods results Acute myocardial infarction (AMI) was induced by ligating left anterior descending (LAD) coronary artery. found to be sharply 12–24 hours after surgery testing LC3 modification Electron microscopy. P62 degradation infarct border zone...
Background: Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus, eventually leads to heart failure. Carvacrol is food additive with diverse bioactivities. We aimed study the protective effects and mechanisms carvacrol in DCM. Methods: used streptozotocin-induced db/db mouse model types 1 2 mellitus (T1DM T2DM), respectively. Both groups received daily intraperitoneal injections for 6 weeks. Cardiac remodeling was evaluated by histological analysis. determined gene...
1. In the present study, we tested hypothesis that long‐term administration of hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor simvastatin may regress hypertrophy and possible effect on angiotensin‐converting enzyme (ACE) activity in rats with pressure‐overload cardiac hypertrophy. 2. Pressure‐overload left ventricular (LVH) was induced by part coarctation abdominal aorta; a sham‐operated group served as control. Six weeks after operation, animals were divided into three...
1. Oxidative mechanisms have been implicated in neonatal cardiomyocyte hypertrophy. We and others shown that a HMG-CoA reductase inhibitor preserves endogenous antioxidant enzyme activity inhibits cardiac hypertrophy vivo. therefore examined whether noradrenaline (NA) induces the generation of reactive oxygen species (ROS) during its induction simvastatin, inhibitor, attenuates ROS production thus NA-induced cardiomyocytes. 2. NA increased intracellular levels concentration-dependent manner....
Sonic hedgehog (SHH) plays an important role in postnatal tissue repair. The present study tested the hypothesis that impaired SHH pathway results delayed wound healing by suppressing cutaneous nitric oxide (NO) function type 1 diabetes. Adult male C57/B6 mice and streptozotocin (STZ)-induced diabetic were used. Although Patched-1 (Ptc-1 encoded PTCH, PTCH 1) proteins increased significantly on day 4 after wounding compared with 0 normal mice, both decreased STZ-induced mice. Topical...
Safe and effective gene delivery is essential to the success of therapy. We synthesized characterized a novel nonviral system in which folate (FA) molecules were functioned as blockers on cationic polyrotaxanes (PR) composed poly(ethylenimine) (PEI)600-grafted α-cyclodextrin rings linearized polyethylene glycol form FA-terminated PR-PEI600 (FPP). The FA terminal caps FPP target cell surfaces abundant receptor (FR), common feature tumor cells. structure was by using 1H nuclear magnetic...
The incidence and mortality of myocardial infarction (MI) in diabetic patients are higher than non-diabetic patients; however, the mechanisms by which diabetes results cardiac dysfunction poorly understood. present study tested hypothesis that an impaired sonic hedgehog (Shh) pathway contributes to type 1 mice with MI.Adult male C57/B6 streptozotocin-induced were used. Myocardial proteins Shh, Patched-1 (Ptc1), glioma-associated oncogene-1 (Gli1) significantly decreased at 10 weeks, this was...
Diabetes is a potent risk factor for heart failure with preserved ejection fraction (HFpEF). Autophagy can be activated under pathological conditions, including diabetic cardiomyopathy. The therapeutic effects of chloroquine (CQ), an autophagy inhibitor, on left ventricle function in streptozotocin (STZ)-induced mice were investigated. cardiac function, light chain 3 (LC3)-II/LC3-I ratio, p62, beclin 1, reactive oxygen species, apoptosis, and fibrosis measured 14 days after CQ (ip 60...
The mechanisms underlying the myocardial protection of valsartan against ischemia/reperfusion (I/R) injury are complicated and remain unclear. aim this study was to investigate whether autophagy machinery involved in I/R that is induced by valsartan. In vivo rat hearts were subjected ischemia 30 min ligation left anterior descending coronary artery, followed a 120 reperfusion. 3‑methyladenine (3‑MA), specific inhibitor on autophagic sequestration, used inhibit autophagy. hemodynamics,...
Maternal high-fat diet (HFD) is associated with cardiovascular disease later in life. This study tested the hypothesis that maternal HFD causes programming of increased cardiac angiotensin II receptor type 2 (AGTR2) expression, resulting heightened susceptibility to ischemic injury male offspring a sex-dependent manner. Pregnant rats were divided between control and (HFD-fed during gestation) groups. resulted hypertrophy only offspring, but had no effect on systolic diastolic function both...