A5101664829- Autophagy in Disease and Therapy
- Renal Diseases and Glomerulopathies
- Physiological and biochemical adaptations
- Cerebrovascular and Carotid Artery Diseases
- Systemic Lupus Erythematosus Research
- Plant tissue culture and regeneration
- Wheat and Barley Genetics and Pathology
- Intracranial Aneurysms: Treatment and Complications
- Cell death mechanisms and regulation
- Photosynthetic Processes and Mechanisms
- Chronic Kidney Disease and Diabetes
- Transgenic Plants and Applications
- Plant Gene Expression Analysis
- Calcium signaling and nucleotide metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Moyamoya disease diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Phytoestrogen effects and research
- Adipose Tissue and Metabolism
- Advances in Cucurbitaceae Research
- 14-3-3 protein interactions
- Spaceflight effects on biology
- Nitrogen and Sulfur Effects on Brassica
- Genetic factors in colorectal cancer
- Acute Kidney Injury Research
China Medical University
2014-2024
Changchun University of Science and Technology
2019-2023
Heilongjiang University
2022-2023
Taizhou Second People's Hospital
2016-2018
Sheng Jing Hospital
2006-2012
Western University
2012
Baylor College of Medicine
2012
Nanjing Agricultural University
1998
Zhengzhou University
1993
Abstract Ischemia–reperfusion injury (IRI)-induced acute kidney (AKI) is a life-threatening disease. The activation of mitophagy was previously identified to play an important role in IRI. Maternally expressed 3 (MEG3) can promote cerebral IRI and hepatic present study designed the MEG3 renal Renal mice models were established, HK-2 cells used construct vitro Hematoxylin–eosin staining assay applied reveal IRI-triggered tubular injury. MitoTracker Green FM ALP kit employed for detection...
Stanniocalcin-1 (STC-1) protects against renal ischemia-reperfusion injury (RIRI). However, the molecular mechanisms remain widely unknown. STC-1 inhibits reactive oxygen species (ROS), whereas most ROS-mediated pathways are associated with ischemic injury. Therefore, to explore mechanism, effects of on ROS-medicated were studied. Non-traumatic vascular clamps used establish RIRI mouse models. The serum levels STC-1, interleukin-6 (IL-6), interferon (IFN) γ, P53, and capase-3 measured by...
OBJECTIVE Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing synthesis and increasing degradation. Since an herbal compound, berberine, lowers blood levels of glucose lipids, we proposed that it would improve signaling, blocking losses. RESEARCH DESIGN AND METHODS We evaluated whether berberine ameliorates atrophy db/db mice, a model type 2 diabetes, measuring degradation muscles normal mice treated with or without berberine. also examined mechanisms for...
Rationale We have previously shown increased cardiac stanniocalcin-1 (STC1) in patients with idiopathic dilated cardiomyopathy. STC1 localizes to the inner mitochondrial membrane and transgenic over-expression of is associated energy utilization. Objective examined hypothesis that uncouples oxidative phosphorylation - suppress superoxide generation modulate neurohormonal effects on cardiomyocytes. Methods Results Compared WT mouse heart, Tg heart displays: 2-fold higher uncoupling protein 3...
Immune activation, chronic inflammation, and renal interstitial fibrosis (RIF) are associated with kidney disease (CKD). The herbal formula, Shenkang injection (SKI), has been reported to attenuate RIF. However, the mechanisms by which SKI alleviates fibrosis, especially role of natural killer (NK) cells, unknown require exploration.This study aimed determine RIF.Differential gene expression between CKD mice control groups was explored using bioinformatics analysis. To reveal how reduces RIF...
The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrated that 14-3-3ε (YWHAE) is responsible for maintaining prophase | arrest mouse oocyte. However, roles of the mitosis fertilized eggs have remained unclear. Here, we showed interacts cooperates with CDC25B phosphorylated at Ser321 regulating G2/M transition mitotic progress eggs. Disruption...
Background/Aims: Hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN) is characterized by a reduced number of podocytes due to apoptosis and shedding from the basement membrane. However, pathological mechanism HBV-GN unclear. We previously showed that hepatitis X protein (HBx) promotes in tubular epithelial cells. In this study, we transfected with HBx examined effects on adhesion these Methods: Podocytes were pc-DNA3.1 (+)-HBx. One control group was not another empty plasmids....
Background/Aims: The hepatitis B virus X protein (HBx) contributes to HBV-induced injury of renal tubular cells and induces apoptosis via Fas/FasL up-regulation. However, the mechanism activation is unknown. Recent studies indicated that HBx induction in hepatic depends on activating MLK3-MKK7-JNKs signaling module, which then up-regulates FasL expression. In this study, we used NRK-52E transfected an expression vector examine role pathway HBx-induced cell injury. Methods: were with...
Abstract The transcription factor methylated c‐Myc heterodimerizes with MAX to modulate gene expression, and plays an important role in energy metabolism kidney injury but the exact mechanism remains unclear. Mitochondrial solute transporter Slc25a24 imports ATP into mitochondria is central metabolism. Gene Expression Omnibus data analysis reveals are consistently upregulated all acute (AKI) cells. Pearson correlation also shows that strongly correlated ( ⍴ > 0.9). Mutant arginine (R299A...
To investigate the mechanism of reversing resistance a hepatic carcinoma multidrug-resistant cell BEL-7402/5-FU with parthenolide (PTL).BEL-7402/5-FU cells were treated different concentrations PTL and/or 5-fluorouracil. The proliferation inhibition rates, NF-κB, P-glycoprotein, MRP, Bcl-2, WNT1 and p53 levels determined.The results showed that did not only have influence on in concentration-dependent manner, but also significantly increased role 5-fluorouracil BEL-7402/5-FU, to reverse...
The inflammatory response and NLRP3 inflammasome activation are typical characteristics of lupus nephritis (LN). Guanylate-binding protein 5 (GBP5) has effects on the release proinflammatory cytokines inflammasome. However, it is largely unknown whether how GBP5 contributes to progression LN.To detect role in LN, MRL/lpr mice were administrated with lentiviral vectors that knockdown via tail vein. Proximal tubular epithelial HK-2 cells treated LPS ATP mimic LN vitro.GBP5 expression was...
Tetramethylpyrazine has been suggested to have a therapeutic effect on impaired hearing that is induced by aminoglycoside antibiotics. However, its effectiveness streptomycin ototoxicity and cellular mechanisms are relatively unknown. Here we investigate the protective of tetramethylpyrazine streptomycin-induced in guinea pig cochlea.Prospective randomized laboratory study.Hearing Research Laboratory China Medical University.Adult pigs were 4 groups. Hearing sensitivity was tested auditory...
ABSTRACT In this work, we present a new type of glutathione (GSH)‐responsive polyurethane‐based core‑shell nanogels (RS‐CS‐PUNGs) with hydrophilic methoxypolyethylene glycols (mPEG) shell, which was prepared by one‐pot synthetic method. The obtained RS‐CS‐PUNGs not only show good size distribution the hydrodynamic radii around 20 nm, but also exhibit stability in organic solvent. results demonstrate that GSH (10 mM) trigger nanogel swelling and accelerate loaded drug release PBS (pH = 7.4)....