A5113855033- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Cardiovascular Function and Risk Factors
- Essential Oils and Antimicrobial Activity
- Biochemical and Structural Characterization
- Click Chemistry and Applications
- Microbial Natural Products and Biosynthesis
- Malaria Research and Control
- Dermatology and Skin Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Diabetes Treatment and Management
- Magnolia and Illicium research
- Cancer therapeutics and mechanisms
- Adipose Tissue and Metabolism
- Bacterial Genetics and Biotechnology
- Probiotics and Fermented Foods
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Synthesis and biological activity
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
Guangzhou Medical University
2018-2025
Kingmed Diagnostics
2020-2025
Urumqi General Hospital of PLA
2009-2021
Sun Yat-sen Memorial Hospital
2020
Sun Yat-sen University
2020
State Key Laboratory of Respiratory Disease
2020
Army Medical University
2011-2015
Northwest University
2008
Artificial intelligence holds great promise for the design of antimicrobial peptides (AMPs); however, current models face limitations in generating AMPs with sufficient novelty and diversity, they are rarely applied to generation antifungal peptides. Here, we develop an alternative pipeline grounded a diffusion model molecular dynamics de novo AMPs. The generated by our have lower similarity identity than those other reported methodologies. Among 40 synthesized experimental validation, 25...
Background: Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus, eventually leads to heart failure. Carvacrol is food additive with diverse bioactivities. We aimed study the protective effects and mechanisms carvacrol in DCM. Methods: used streptozotocin-induced db/db mouse model types 1 2 mellitus (T1DM T2DM), respectively. Both groups received daily intraperitoneal injections for 6 weeks. Cardiac remodeling was evaluated by histological analysis. determined gene...
ABSTRACT The emergence of Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern worldwide. PVL associated with community-associated MRSA and linked to skin soft tissue infections (SSTIs). However, genes have also been detected in care-associated (HA) isolates. diseases PVL-positive HA-MRSA isolates the distributions PVL-encoding bacteriophages not determined. In this study, total 259 strains isolated between 2009 2012 China...
Because of the rapid increase in bacterial resistance, there is an urgent need for developing new antimicrobial agents to combat multidrug-resistant pathogens. In this study, we designed and synthesized a series kaempferol derivatives as biomimicking structural properties biological functions host defense peptides. After fine-tuning hydrophobic cationic hydrophilic moieties linked flavone scaffold kaempferol, obtained lead compound (52) that displayed high membrane selectivity (>128), poor...
ObjectivesMethicillin-resistant Staphylococcus aureus (MRSA) infection is increasing and causing global concern. The mechanism of MRSA resistance to amikacin poorly understood. We report on the first matched-pair study reveal that phenotypic cell wall thickening associated with adaptive amikacin.
Staphylococcus aureus (S. aureus) is one of the important human pathogens and causes both superficial systemic infections. More importantly, formation S. biofilms, a main cause its pathogenicity drug resistance, has been critical challenge in clinical treatment. Carvacrol, plant-based natural product, gained great interest for therapeutic purposes due to effective biological activity with low cytotoxicity. The present study aimed investigate effect carvacrol on anti-biofilm activity. Growth...
Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease. Staphylococcus aureus the key microbial factor in AD, linked to disease activity. However, there limited knowledge of genomic prevalence characteristics and phenotypic features S. AD patients China. We investigated 108 China globally publicly available genome sequences 579 AD. Sequence type (ST) 7, ST15 ST188 were major lineages Genes esaC, esxB, sea only detected ST7, potentially contributing its exhibited high virulence...
Sequence type (ST) 239 with SCCmec III methicillin-resistant Staphylococcus aureus (ST239-MRSA-III) is the most predominant multidrug-resistant clone in China. The subclone ST239-MRSA-III-t037 has been gradually replaced ST239-MRSA-III-t030 since 2000. Subclones are characterized by drug resistance profiles. However, mechanisms of clonal dynamics and determinants distinct remain poorly understood. In present study, 12 strains were collected from Chongqing, Guangzhou, Shanghai; these selected...
Staphylococcus aureus is among the most common causes of health care- and community-associated infections worldwide. The distributions different S. clones change over time also vary geographically. purpose this study was to determine molecular type antimicrobial resistance profiles clinical strains isolated in Urumqi, Northwestern China.A total 605 isolates were collected from Xinjiang Military General Hospital, Urumqi. Protein A-encoding (spa) typing, multilocus sequence staphylococcal...
The antibacterial activity and the synergistic effect with β-lactam antibiotics of a new 1-methylquinolinium iodide derivative were investigated. experimental results indicate that compound possesses strong against panel bacteria including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus NDM-1 Escherichia coli MIC values from 0.75 μg/mL to 6 μg/mL. In addition, this combined shows antimicrobial activities antibiotic-resistant strains S. aureus. biochemical...
Bacterial biofilms do serious harm to the diabetic foot ulcer (DFU) because they play a crucial role in infection invasion and spread. Staphylococcus aureus, predominant Gram-positive bacteria (DFI), is often associated with colonization biofilm formation. Through formation tests vitro, we observed that S. aureus isolated from DFU wounds were more prone form than those non-diabetic patients, while there was no difference blood sugar between (+) diabetics (DB+) (-) (DB-). Furthermore, found...
Background: The prevalence of drug-resistant bacterial infections urges the development new antibacterial agents that possess a mechanism action different from traditional antibiotics. FtsZ has been recognized as key functional protein in cell division and it is currently believed to be potential target for novel agents. Purpose: primary aim study screen out an inhibitor targeting at followed investigate its activity mode action. Methods: Cell-based inhibitory screening assay, antimicrobial...
Abstract Background Carvacrol is a food additive with various bioactivities, including reducing the blood glucose level as well improvement of heart function, in diabetic mice. We explored antihyperglycemic effect carvacrol and its on key hepatic enzymes accounting for metabolism. Methods A streptozotocin (STZ)-induced diabetes-mellitus model mice was used. Mice were divided randomly into control group, low dose carvacrol-treated group (10 mg/kg body weight [BW]), high (20 BW). injected...
Methazolamide (MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit cardiomyocyte hypertrophy and exert hypoglycemic effect in patients with type 2 diabetes diabetic db/db mice. However, whether MTZ cardioprotective the setting of cardiomyopathy is not clear. We investigated effects mouse model streptozotocin-induced 1 mellitus (T1DM). Diabetic mice received by intragastric gavage (10, 25, or 50 mg/kg, daily for 16 weeks). In group, significantly reduced both random fasting blood...
Dengue viruses (DENVs) are mosquito-borne infectious pathogens that pose a serious global public health threat, and at present, no therapy or effective vaccines available. Choosing suitable units as candidates is fundamental for the development of dengue subunit vaccine. Domain III DENV-2 E protein (EDIII) was chosen in present study expressed Escherichia coli by N-terminal fusion to bacterial leader (pelB), C-terminal with 6×His tag based on functions DENV structure proteins, especially...