A5100321916- Signaling Pathways in Disease
- S100 Proteins and Annexins
- Trace Elements in Health
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Cardiovascular Function and Risk Factors
- Child Nutrition and Water Access
- Sesquiterpenes and Asteraceae Studies
- Iron Metabolism and Disorders
- Autophagy in Disease and Therapy
- Clusterin in disease pathology
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Regulation of Appetite and Obesity
- Microbial Metabolism and Applications
- Protein Kinase Regulation and GTPase Signaling
- Sulfur Compounds in Biology
- Tannin, Tannase and Anticancer Activities
- Nerve injury and regeneration
- Phytochemistry and Bioactivity Studies
- Cardiac Health and Mental Health
- Luminescence and Fluorescent Materials
- Extracellular vesicles in disease
Guangzhou Medical University
2016-2025
Guangdong Institute of Biological Products and Drugs
2022-2025
State Key Laboratory of Respiratory Disease
2019-2024
Boston Children's Hospital
2022
Second Affiliated Hospital of Guangzhou Medical University
2018-2019
Sun Yat-sen University
2008-2016
Hunan Normal University
2010
Background: Diabetic cardiomyopathy (DCM), a common complication of diabetes mellitus, eventually leads to heart failure. Carvacrol is food additive with diverse bioactivities. We aimed study the protective effects and mechanisms carvacrol in DCM. Methods: used streptozotocin-induced db/db mouse model types 1 2 mellitus (T1DM T2DM), respectively. Both groups received daily intraperitoneal injections for 6 weeks. Cardiac remodeling was evaluated by histological analysis. determined gene...
Non-small cell lung cancer (NSCLC), one type of cancer, owns high rates morbidity and mortality. B-Raf is the promising oncogenic drivers NSCLC. Parthenolide, a natural product, mainly extracted from herbal plant Tanacetum parthenium. The effect parthenolide on NSCLC cells its potential as inhibitor were studied in this study. It's shown that exhibited strong cytotoxicity against with IC50 ranging 6.07 ± 0.45 to 15.38 1.13 μM. Parthenolide was also able induce apoptosis, suppress...
Monascus red (MR) is widely used as a natural food colorant and preservative in East Asia. However, the potential effects of MR during pregnancy remains unknown. In this study, was administrated to Sprague-Dawley (SD) rats at doses 0, 0.50, 1.58, 5.00g/kg bw on gestational days 6-15 by oral gavage. maternal embryo-fetal examinations, there were no marked toxicities terms general clinical signs, body weight, consumption, serum endocrine indices, organ weights, thyroid histopathology,...
Myocardial infarction (MI) remains a major cause of chronic heart failure. Endoplasmic reticulum (ER) stress is an emerging therapeutic strategy to prevent adverse remodeling the infarcted heart. However, little known about how Bax-interacting protein 1 (Bif-1), member endophilin B family, involved in mediating cardiac ER ischemic disease. Here, combination left anterior descending (LAD) coronary artery ligation mouse model and adenovirus-based transfection was used investigate effect Bif-1...
Costunolide being a sesquiterpene lactone, is known to have anticancer properties. The present study investigated the effects of costunolide against H1299 human non‑small‑cell lung cancer (NSCLC) cell line. Inhibition viability by was assessed via MTT assay. Furthermore, apoptotic rate detected using Annexin V/propidium iodide labeling. A colony forming assay performed investigate antiproliferative costunolide. Wound healing and Transwell assays were determine inhibitory on migration...
Abstract There is a large amount of evidence that selective serotonin reuptake inhibitors (SSRIs) are related to cardiovascular toxicity, which has aroused concern regarding their safety. However, few studies have evaluated the effects SSRIs on cardiac injury biomarkers, such as creatine kinase (CK) and isoenzyme (CK-MB). The purpose our study was determine whether elevated CK CK-MB levels prior medicated depressive patients (PMDP) compared first-episode drug-naïve (FDDPs). We performed an...
Background: Apicidin, as an inhibitor of histone deacetylase, showed a wide range antiproliferative activity against various cancer cell lines. Apicidin has also been reported to induce apotosis via Fas/Fas ligand. Yet few studies have focused on mitochondrial pathway for its anti-tumor activity. Objective: In this study, we evaluated involved mechanism non-small lung GLC-82 cells. Method: was isolated from the mangrove endophtic fungi Fusarium sp. by solvent extraction and column...
Vascular complications induced by diabetes constitute the principal cause of morbidity and mortality in diabetic patients. It has been reported that carvacrol (CAR) possesses a wide range biological activities. The effects CAR on diabetes-induced vasculopathy remain unknown. In this study, mice were created intraperitoneal injection streptozotocin (STZ) male C57BL/6 J to investigate whether provided protective effect against underlying mechanisms. We found decreased blood glucose levels...
Abstract Cardiac hypertrophy is one of the major risk factors for chronic heart failure. The role endophilinA2 (EndoA2) in clathrin‐mediated endocytosis and clathrin‐independent well documented. In present study, we tested hypothesis that EndoA2 protects against angiotensin II (Ang II)‐induced cardiac by mediating intracellular type 1 receptor (AT1‐R) trafficking neonatal rat cardiomyocytes (NRCMs). was evaluated using cell surface area quantitative RT‐PCR (qPCR) analyses. For first time,...
Abstract Objectives Accumulating evidence demonstrates that copper deficiency (CuD) is a risk factor for cardiovascular diseases, besides, fructose has been strongly linked to the development of diseases. However, how CuD or causes diseases not clearly delineated. The present study aims investigate mechanism on cardiac remodeling. Methods We established model CuD- fructose-induced hypertrophy in 3-week-old male Sprague–Dawley (SD) rats by diet supplemented with without 30% 4 weeks. In vitro...
Natural products from the genus Euphorbia show attention-attracting activities, such as anticancer activity. In this article, classical isolation and structure identification were used in a study on Caper Seed. Subsequently, MTT wound healing assays, flow cytometry, western blotting, Hoechst 33258 staining fluorescence microscopy examination applied to investigate activity of obtained compounds. result, lathyrol-3-phenyl- acetate-5,15-diacetate (deoxy factor L1, DEFL1) was isolated Moreover,...
Two GPR39 transcripts, designated as sbGPR39-1a and sbGPR39-1b, were identified in black seabream ( Acanthopagrus schlegeli ). The deduced amino acid (aa) sequence of contains 423 residues with seven putative transmembrane (TM) domains. On the other hand, sbGPR39-1b 284 aa only five TM Northern blot analysis confirmed presence two transcripts intestine, stomach, liver. Apart from seabream, was also found to exist a number teleosts (zebrafish pufferfish) mammals (human mouse). Analysis gene...
Cinobufagin (CB), with its steroidal nucleus structure, is one of the major, biologically active components Chan Su. Recent studies have shown that CB exerts inhibitory effects against numerous cancer cells. However, regarding metastasis non-small cell lung (NSCLC) and involved mechanisms need to be further studied. The purpose present study aimed report function proliferation H1299 inhibited cells an IC50 value 0.035±0.008 μM according results MTT assays. Antiproliferative activity was also...
Cardiac injury upon myocardial infarction (MI) is the leading cause of heart failure.The present study aims to investigate role EndoA2 in ischemia-induced cardiomyocyte apoptosis and cardiac injury.In vivo, we established an MI mouse model by ligating left anterior descending (LAD) coronary artery, intramyocardial injection adenoviral (Ad-EndoA2) was used overexpress EndoA2.In vitro, siRNA Ad-EndoA2 transfection strategies.Here, reported that expression remarkably elevated infarct border...