A5101692561- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- 14-3-3 protein interactions
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Advanced Biosensing Techniques and Applications
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Fatty Acid Research and Health
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
Guangdong Provincial People's Hospital
2008-2025
North China Electric Power University
2025
Guangdong Academy of Medical Sciences
2015-2024
Southern Medical University
2023-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Guangdong General Hospital
2011-2022
Nanjing Medical University
2020-2022
Obesity is a major risk factor for the development of cardiovascular disease. Emerging evidence indicates that leptin, protein encoded by obesity gene, linked with cardiac hypertrophy in obese humans and directly induces cardiomyocyte vitro. However, mechanisms which leptin are poorly understood.This study investigated how contributes to hypertrophy. Cultured neonatal rat cardiomyocytes were used evaluate effects on Both endothelin-1 (ET-1) reactive oxygen species (ROS) levels elevated...
We have previously shown that dysregulation of miR-21 functioned as an oncomiR in breast cancer. The aim the present study was to elucidate mechanisms by which regulate tumor migration and invasion. applied pathway analysis on genome microarray data target-predicting algorithms for target screening, used luciferase reporting assay confirm direct target. Thereafter, we investigated function gene phosphoinositide-3-kinase, regulatory subunit 1 (α) (PIK3R1), detected PIK3R1 coding protein...
Abstract Reasonable scheduling and control of air‐source heat pumps (ASHPs) contribute to reducing operational costs for users while encouraging their participation in grid demand response. This article proposes a two‐layer optimal strategy ASHP loads incorporating phase change energy storage (PCES). First, an electricity‐heat coupling model is proposed. integrates PCES technology considers the influence outlet water temperature, ambient cold island effect on coefficient performance....
Background: Our retrospective study in breast cancer patients evaluated whether integrating subtype and pathologic complete response (pCR) information into axillary lymph node restaging after neoadjuvant chemotherapy (NAC) adds significance to its prognostic values. Methods: Patients included the analysis had stage II or III disease, with post-NAC dissection (ALND), without sentinel biopsy before completion of NAC, definitive subtyping data subtype-oriented adjuvant treatments. The ypN...
Purpose The present study sets out to evaluate the feasibility, safety, and effectiveness of conversion surgery following induction immunochemotherapy for patients with initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in a real-world scenario. Materials Methods In this multi-center, (NCT04822103), who had ESCC disease were enrolled across eight medical centers China. All received programmed death receptor-1 (PD-1) inhibitor plus chemotherapy every 3 weeks at...
Abstract Background Accurately assessing HER2-low (immunohistochemistry [IHC] 1 + and IHC 2+/in situ hybridization [ISH]–) HER2-ultralow (IHC > 0 < 1+) is essential given the emergence of novel therapies. Thorough understanding reproducibility rescoring stained slides or re-staining archived tissue essential. Methods 2,869 breast cancer patients diagnosed between July 2021 2022 from 10 hospitals in China were included this multicentre study. The prevalence different HER2 expression...
We used methylation-sensitive restriction fingerprinting (MSRF) to identify novel CpG (5'-CG-3' palindrome; p, phosphate group)-rich sequences that are methylated differentially between the hepatocellular carcinoma (HCC) genomes and adjacent nontumorous liver tissues. A 199-base-pair sequence in HCC tumor tissue was isolated showed high homology 5' island of zinc fingers homeoboxes protein 2 (ZHX2) gene. By using bisulfite sequencing, we confirmed hypermethylation ZHX2 occurred some HepG2...
The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role in diffuse large B-cell lymphoma (DLBCL) development remains unclear.We evaluated expression patient samples DLBCL using immunohistochemical staining. effect overexpression on cell viability and apoptosis was investigated activated (ABC) like lines. mechanism activity immunoprecipitation, ubiquitination, western blot qualitative analyses.The non-germinal center...
F-box and WD repeat domain-containing 7 (Fbw7) is well known as a tumor suppressor ubiquitin ligase which targets variety of oncogenic proteins for proteolysis. We previously reported that Fbw7 promotes apoptosis in diffuse large B-cell lymphoma (DLBCL) through Fbw7-mediated ubiquitination Stat3. This study aimed to identify the mechanism aerobic glycolysis reprogramming DLBCL.Expression levels Lactate Dehydrogenase A (LDHA) human DLBCL samples were evaluated by immunohistochemistry....
We used methylation-sensitive restriction fingerprinting (MSRF) to identify novel CpG (5'-CG-3' palindrome; p, phosphate group)–rich sequences that are methylated differentially between the hepatocellular carcinoma (HCC) genomes and adjacent nontumorous liver tissues. A 199-base-pair sequence in HCC tumor tissue was isolated showed high homology 5'-CpG island of zinc fingers homeoboxes protein 2 (ZHX2) gene. By using bisulfite sequencing, we confirmed hypermethylation ZHX2 occurred some...
Primary cardiac lymphoma (PCL) is a rare neoplasm. PCL fatal, unless it diagnosed and treated early. Recently, small number of cases diffuse large B cell (DLBCL) arising within atrial myxoma have been reported in immunocompetent patients showed aggressive histological features but an indolent clinical behaviour.We present four unusual Epstein-Barr virus (EBV)-positive DLBCL with detailed clinical, histological, immunophenotypical genotypical patients, review the literature for 11 similar...
Abstract Background The dietary nutritional status of the lactating mothers is related to maternal health and has a significant impact on growth development infants through secretion breast milk. food frequency questionnaire (FFQ) most cost-effective assessment method that can help obtain information usual pattern participants. Until now, FFQs have been used for different populations in China, but there are few available mothers. We aimed develop semi-quantitative, 156-item FFQ Chinese...
The purpose of this study was to investigate the correlation between tau expression in primary breast cancer and sensitivity taxanes during neoadjuvant chemotherapy patients with cancer. We used immunohistochemistry examine biopsies from 113 evaluated taxane sensitivity. Twenty-eight (24.78 %, 28/113) were positive for expression. After taxanes-based chemotherapy, 40 achieved pathological complete response (pCR) (35.4 %). Among pCR, five (12.5 %) In univariate analysis, estrogen receptor...
To determine the diagnostic potential of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM)-derived parameters for differentiation benign, intermediate, malignant solid soft-tissue tumors.The Institutional Review Board approved this prospective study, informed consent was obtained. IVIM imaging performed in 64 patients including 44 6 14 tumors at 1.5T. The were assessed using Kruskal-Wallis test. performance evaluated receiver operating characteristic (ROC)...
We compared the American Society of Clinical Oncology/College Pathologists (ASCO/CAP) immunohistochemical scoring criterion (30%) for determining HER2 status and Food Drug Administration (10%) with fluorescence in situ hybridization (FISH), gene amplification method 328 cases breast cancer. Of 294 tumor samples successfully analyzed simultaneously by FISH immunohistochemically, 178 196 scored 3+ using 10% 30% criteria. Using as reference, number false-positives was reduced from 24 to 9 after...
Population research on the intervention of docosahexaenoic acid (DHA) supplementation in lactating women is its infancy China. This study investigated effect DHA concentrations breast milk women, and effect, with respect to different dietary patterns. In this trial, 160 healthy Nanjing (30−50 days postpartum) were recruited randomly divided into control (one placebo capsule similar appearance per day) supplement 200 mg from algal oil groups for 8 weeks. Before after intervention, all...
Abstract Mammary mucoepidermoid carcinoma (MEC) is a rare entity. The molecular characteristics of breast MEC have not been fully investigated due to its rarity. We performed retrospective study among 1000 patients with carcinomas and identified four cases MEC. Clinical demographic data were collected. Immunohistochemistry panels which used diagnose salivary gland also performed. MAML2 rearrangements detected by FISH fusion partners RNA sequencing. Whole-exome sequencing (WES) was reveal the...