A5102858313- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- BRCA gene mutations in cancer
- PI3K/AKT/mTOR signaling in cancer
- Breast Implant and Reconstruction
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
Guangdong Provincial People's Hospital
2006-2024
South China University of Technology
2020-2024
Guangdong Academy of Medical Sciences
2014-2024
Guangdong General Hospital
2012-2024
Southern Medical University
2018-2024
Second Affiliated Hospital of Harbin Medical University
2018-2023
Harbin Medical University
2018-2023
Shantou University
2021-2022
Shantou University Medical College
2021-2022
Peking University First Hospital
2020
Abstract Background HER2-low breast cancers were reported to have distinct clinicopathological characteristics from HER2-zero; however, the difference in their genetic features remains unclear. This study investigated clinical and molecular of tumors according HER2 status. Methods We analyzed genomic data 523 Chinese women with cancer. Genomic was generated by targeted next-generation sequencing (NGS) tumor samples using a commercial 520 gene panel. The cohort stratified status as HER2-zero...
Background: The complexity of breast cancer at the clinical, morphological and genomic levels has been extensively studied in western population. However, mutational profiles Chinese patients have not explored any detail. Methods: We performed targeted sequencing using a panel consisting 33 cancer-related genes to investigate landscape 304 consecutive treatment-naïve Guangdong Provincial People's Hospital (GDPH), further compared results those 453 Caucasian from Cancer Genome Atlas (TCGA)....
The data on the phenotypes associated with some rare germline mutations in Chinese breast cancer patients are limited.The difference somatic mutation profiles BRCA and non-BRCA remains unexplored.We interrogated mutational profile of 524 various stages unselected for predisposing factors using a panel consisting 520 cancer-related genes including 62 susceptibility genes.We divided into three groups according to mutations: Germline-BRCA1/2, Germline-others (non-BRCA) Others (non-carriers).A...
Abstract Breast cancer (BC) is characterized by high morbidity. Mitochondrial ribosomal protein (MRP) family participates in mitochondrial energy metabolism, underlying BC progression. This study aims to analyze the expression and prognosis effect of MRP genes patients. GEPIA2, UALCAN, cBioPortal, MethSurv were used demonstrate differential expression, genomic alteration profiles, DNA methylation gene BC. Functional enrichment analysis protein–protein interaction network construction...
Background: Our retrospective study in breast cancer patients evaluated whether integrating subtype and pathologic complete response (pCR) information into axillary lymph node restaging after neoadjuvant chemotherapy (NAC) adds significance to its prognostic values. Methods: Patients included the analysis had stage II or III disease, with post-NAC dissection (ALND), without sentinel biopsy before completion of NAC, definitive subtyping data subtype-oriented adjuvant treatments. The ypN...
There are significant differences in the biological behavior between triple-negative breast cancer (TNBC) and non-triple-negative (non-TNBC). In present study, we identify key differential genes clinical outcomes TNBC non-TNBC.Transcriptomic analyses used GEO datasets (GSE76275), gene ontology, KEGG pathway analysis cBioPortal. Quantitative RT-PCR (qRT-PCR) was to validate differentially expressed genes. We KM Plotter Online Tool 240 patients with tissue microarray assay prognostic value of...
As an important regulator of epigenetics, histone lysine methyltransferase 2C (KMT2C), is frequently mutated in multiple human cancers and considered to be crucial for the occurrence development numerous cancers. However, relationship between KMT2C mutation clinicopathological characteristics patients with breast cancer unclear. In present study, we performed next-generation sequencing investigate status 411 treatment-naive Chinese at Guangdong Provincial People's Hospital (GDPH), further...
Comprehensive analysis of PI3K-AKT-mTOR pathway gene alterations in breast cancer may be helpful for targeted therapy.
HER2-positive breast cancer is a biologically and clinically heterogeneous disease. Based on the expression of hormone receptors (HR), tumors can be further categorized into HR positive negative. Here, we elucidated comprehensive somatic mutation profile HR+ HR- to understand their molecular heterogeneity. In this study, 64 HR+/HER2+ 43 HR-/HER2+ stage I-III patients were included. Capture-based targeted sequencing was performed using panel consisting 520 cancer-related genes, spanning 1.64...
Abstract Background Recent studies have shown that selenium-binding protein 1 (SELENBP1) is significantly down-regulated in a variety of solid tumors. Nevertheless, the clinical relevance SELENBP1 human bladder cancer has not been described any detail, and molecular mechanism underlying its inhibitory role cell growth largely unknown. Methods expression levels tumor tissues adjacent normal were evaluated using immunoblotting assay. The association expression, clinicopathological features,...
Abstract Background Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool improve prognosis prediction BC patients. Methods We obtained IRL expression profiles large cohorts (N = 911) from The Cancer Genome Atlas (TCGA) database. Then, light of the correlation between each and recurrence-free survival (RFS), screened prognostic signatures construct a novel RFS nomogram...
The outbreak of 2019 novel coronavirus disease (COVID-19) has gained intense attention, not only within China but internationally [1Khan S. Siddique R. Ali A. Xue M. Nabi G. Novel coronavirus, poor quarantine, and the risk pandemic.J Hosp Infect. 2020; https://doi.org/10.1016/j.jhin.2020.02.002Abstract Full Text PDF Scopus (61) Google Scholar,2Khan is putting whole world on alert.J https://doi.org/10.1016/j.jhin.2020.01.019Abstract (69) Scholar]. We report a infection control measure:...
Abstract Accumulating evidence revealed that autophagy played vital roles in breast cancer (BC) progression. Thus, the aim of this study was to investigate prognostic value autophagy‐related genes (ARGs) and develop a ARG‐based model evaluate 5‐year overall survival (OS) BC patients. We acquired ARG expression profiling large cohort (N = 1007) from The Cancer Genome Atlas (TCGA) database. correlation between ARGs OS confirmed by LASSO Cox regression analyses. A predictive established based...
Various genomic alterations and signatures, including ERBB2 amplification, mutations in PIK3CA, AKT1, ESR1, tumor mutational burden (TMB), have become important biomarkers for treatment selection breast cancer (BC). This study aimed to investigate the features of Chinese early-stage BC patients.Tumors matched blood samples collected from 589 patients with were sequenced using a commercial gene panel consisting 520 cancer-related genes analyze all types estimate TMB status.A total 18 found be...
Background: We assessed the accuracy and reproducibility of ChatGPTs recommendations in response to breast cancer cases by comparing generated outputs with consensus expert opinions.Methods: 362 consecutive sourced from a weekly international webinar series (April 2020 July 2023) were submitted tumor board renowned experts. The same clinical also prompted ChatGPT-4.0 three separate times.Findings: Only 46% ChatGPT-generated content was entirely concordant experts, only 39% ChatGPT's...
The purpose of this study was to investigate the correlation between tau expression in primary breast cancer and sensitivity taxanes during neoadjuvant chemotherapy patients with cancer. We used immunohistochemistry examine biopsies from 113 evaluated taxane sensitivity. Twenty-eight (24.78 %, 28/113) were positive for expression. After taxanes-based chemotherapy, 40 achieved pathological complete response (pCR) (35.4 %). Among pCR, five (12.5 %) In univariate analysis, estrogen receptor...
Dyslipidemia International Study II (DYSIS II)-China was conducted to determine the low-density lipoprotein cholesterol (LDL-C) goal (<1.8 mmol/L) attainment rate in patients with post-acute coronary syndrome (ACS).Compliance treatment guideline recommendations improves LDL-C post-ACS patients.This multicenter prospective observational study at 28 tertiary hospitals determined rates admission and 6-month follow-up on lipid-lowering (LLT) for ≥3 months those not LLT (LLT-naive or off months)...