A5101601558- Optical Coherence Tomography Applications
- Maternal and fetal healthcare
- Hedgehog Signaling Pathway Studies
- Cervical Cancer and HPV Research
- Ectopic Pregnancy Diagnosis and Management
- Diverticular Disease and Complications
- Laser Material Processing Techniques
- Global Cancer Incidence and Screening
- Microwave Engineering and Waveguides
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Ocular and Laser Science Research
- Advanced Fluorescence Microscopy Techniques
- Kruppel-like factors research
- Hormonal and reproductive studies
- Cancer survivorship and care
- Radio Frequency Integrated Circuit Design
- Gestational Diabetes Research and Management
- Reproductive Health and Contraception
- Genital Health and Disease
- Photoacoustic and Ultrasonic Imaging
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Prostate Cancer Diagnosis and Treatment
State Key Laboratory of Respiratory Disease
2020-2024
Guangzhou Medical University
2010-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2019-2023
Sun Yat-sen University
2019-2023
Huazhong University of Science and Technology
2008-2023
Yangtze University
2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2022
Guangzhou Women and Children Medical Center
2010-2020
Second Affiliated Hospital of Guangzhou Medical University
2015-2020
Affiliated Hospital of North Sichuan Medical College
2010-2020
Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China's national cervical cancer screening program.To evaluate hrHPV as a new modality for program.This population-based, multicenter, open-label, randomized clinical trial took place across 20 primary health care centers in urban and rural areas China. At least 3000 women aged 35 to 64 years per site were invited participate, total 60 732 evaluated.At baseline, randomly assigned cytology,...
Persistent human papillomavirus (HPV) infections is necessary for the development of cervical cancers. An increasing number retrospective studies have found depletion Lactobacillus microbiota in cervico-vagina facilitate HPV infection and might be involved viral persistence cancer development. However, there been no reports confirming immunomodulatory effects isolated from cervico-vaginal samples clearance women. Using persistent women, this study investigated local immune properties mucosa....
Objective. To examine the association of polycystic ovary syndrome (PCOS) in early pregnancy with gestational diabetes mellitus (GDM) and adverse birth outcomes. Methods. In this retrospective cohort study including 2389 pregnant women, medical records 352 women diagnosed PCOS were evaluated. Outcomes included GDM, preterm birth, low weight, macrosomia, being small large for age. Multivariable logistic regression models used to risk GDM outcomes after adjusting confounders. Results. Women...
Breast cancer is the most frequently occurring in women globally, using radical mastectomy as main clinical treatment. This study aims to investigate quality of life and related factors patients after breast reconstruction.Female undergoing reconstruction between February 20, 2014 2019 Department Tumor or Thyroid Surgery Affiliated Hospital North Sichuan Medical College Nanchong Central were surveyed. The patients' basic information was collected a questionnaire prepared by research team,...
Diabetic retinopathy (DR) is a major microvascular complication in diabetics, and its mechanism not fully understood. Toll-like receptor 4 (TLR4) plays pivotal role the maintenance of inflammatory state during DR, deletion TLR4 eventually alleviates diabetic state. To further elucidate we used bone marrow transplantation to establish reciprocal chimeric animals mutant mice WT combined with diabetes mellitus (DM) induction by streptozotocin (STZ) treatment identify different cell types...
Damaged endothelial progenitor cells (EPCs) are associated with poor prognosis in diabetic myocardial infarction (DMI). Our previous studies revealed that an impaired Sonic hedgehog (Shh) pathway contributes to insufficient function EPCs; however, the roles of Shh EPC apoptosis under basal and hypoxic/ischemic conditions remain unknown. Therefore, present study investigated whether revitalized EPCs consequently improved deteriorative status DMI. For this purpose, streptozotocin injection was...
Aims: SUMOylation is a post-translational modification that plays crucial role in the cellular stress response. We aimed to demonstrate whether and how SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods Results: Adenovirus expressing was administrated by multipoint injection border zone of heart immediately after MI C57BL/6 mice. Neonatal rat cardiomyocytes (NRCMs) were also infected, oxygen glucose deprivation (OGD) followed. In vivo, adenovirus-injected...
Our previous study demonstrated that an impaired sonic hedgehog (Shh) pathway contributed to cardiac dysfunction in type 1 diabetic mice with myocardial infarction (MI). The present aimed test the hypothesis oxidative stress may contribute Shh and MI. Streptozotocin‑induced (C57/Bl6, male) rat neonatal cardiomyocytes were used study. Mice randomly assigned undergo ligation of coronary artery or pseudosurgery. A potent antioxidant Tempol was administered vivo vitro. Cardiac function assessed...
This letter presents the design of magic-T using low-temperature co-fired ceramic (LTCC) technology by microstrip-slotline transitions and aperture-coupled structures. The is designed to work at center frequency 21 GHz with bandwidth 8 GHz. size circuit only 6 mm × due LTCC multilayer Measured data numerical simulations show good amplitude phase characteristics, high isolation also achieved.
Covalent modification of cellular proteins by chemically reactive compounds/metabolites has the potential to disrupt biological function and elicit serious adverse drug reactions. Information on nature binding patterns protein targets are critical toward understanding mechanism induced toxicity. Protein covalent studies established in liver microsomes can quantitively estimate extent modification, but they provide little information modified proteins. In this article, we describe a...
This retrospective, cohort study examined the association between maternal pre-pregnancy body mass index (BMI), independent of glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), for which there are few previous studies. Medical records from 2012 to 2015 at Guangzhou Women Children's Center, China were reviewed previously diagnosed PCOS normal 2-h 75-g oral test (OGTT) results (n = 1249). The separate joint effects BMI levels on assessed. Maternal...
A Fourier domain optical coherence tomography (OCT) system with 1310 nm light was demonstrated to study inflammatory human skin and the coated a moisturizer in vivo. By using graphics processing unit (GPU), display rate could reach 20 frames/s 1000 A-scans contained one image. The field of view (FOV) cross-sectional image is 7 mm lateral direction penetration depth ∼1 skin. result shows that, skin, epidermis became thicker had decreased scattering; furthermore, region severe lesion present...
We previously suggested that endogenous glucocorticoids (GCs) may inhibit myocardial inflammation induced by lipopolysaccharide (LPS) in vivo. However, the possible cellular and molecular mechanisms were poorly understood. In this study, we investigated role of physiological concentration GCs LPS cardiac fibroblasts explored mechanisms. The results showed hydrocortisone at dose 127 ng/mL (equivalent to basal level GCs) inhibited (100 ng/mL)-induced productions TNF-α IL-1β fibroblasts....
Abstract Background Diverticulum, one of the long-term sequelae cesarean section, can cause abnormal uterine bleeding, dysmenorrhea and chronic pelvic pain. Hysteroscopic resection diverticula is thought to reduce bleeding In this study, we aim describe improvement after hysteroscopic section (CSD) in women without childbearing intention, explore variables associated with poor prognosis. Methods A retrospective cohort study aged 25–48 CSD diagnosis by transvaginal ultrasonography (TVS)...
This study clarifies the ablation differences in air and water for hard biological tissues, which are irradiated by fiber-guided long-pulsed holmium lasers. High-speed photography is used to record dynamic characteristics of plumes vaporization bubbles induced pulsed The morphologies depth tissues quantitatively measured optical coherence microscopy. Explosive effects play a positive role contact process directly responsible significant enhancement. Furthermore, layer can also contribute...