A5101410628- Hormonal and reproductive studies
- Obstructive Sleep Apnea Research
- Neurobiology of Language and Bilingualism
- Pharmacogenetics and Drug Metabolism
- Urinary Bladder and Prostate Research
- Drug Transport and Resistance Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Reading and Literacy Development
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Gout, Hyperuricemia, Uric Acid
- Fungal Infections and Studies
- Synthesis and Biological Evaluation
- Esophageal and GI Pathology
- Prostate Cancer Treatment and Research
- Plant Toxicity and Pharmacological Properties
Guangzhou Medical University
2014-2024
Huzhou Central Hospital
2024
University of Malaya
2023-2024
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Dalian University
2023-2024
Liaoning Normal University
2023-2024
State Key Laboratory of Respiratory Disease
2020-2024
First Affiliated Hospital Zhejiang University
2023
Jining Medical University
2022-2023
Tumor necrosis factor-alpha (TNFα) plays a pivotal role in inflammation-related osteoporosis through the promotion of bone resorption and suppression formation. Numerous drugs have been produced to treat by inhibiting resorption, but they offer few benefits formation, which is what needed patients with severe loss. Melatonin, can exert both anti-inflammatory pro-osteogenic effects, shows promise overcoming TNFα-inhibited osteogenesis deserves further research. This study demonstrated that...
Abstract Research on the cognitive neural mechanisms of language control often overlooks role rewards. To investigate how reversal rewards affect bilingual switching during observational learning, we conducted a dual-brain electroencephalography (EEG) study. Participants, classified as direct learners or observers, performed voluntary language-switching task under dynamic reward conditions. Our results demonstrated that both and observers exhibited high correct acquisition rates for switch...
Four new curvularin-type macrolides were isolated from a marine fungus <italic>Penicillium Sumatrense</italic> and their absolute configurations determined by CD spectra modified Mosher's methods.
Malicious attacks in wireless cyber-physical systems have become more frequent recent years. With the development of attack methods used by attackers, security needs to progress match various attacks. Deep learning is a field that has developed rapidly years, and generative adversarial network (GAN) deep model shown promising results. GAN two interlocking subsystems, one generate fake samples another classify generated samples. Finally, system well trained subsystems are capable both...
Purpose: We aimed to develop a novel index, the hypoxia burden index (HBI), that reflects degree and duration of oxygen desaturation, determine whether this is better than apnea hypopnea-index (AHI) for evaluating obstructive sleep (OSA) cardiovascular diseases morbidities.Methods: retrospectively analyzed 459 adult subjects who underwent overnight polysomnography (PSG) in study. The HBI was calculated by dividing total desaturation area SpO2 below 90% TST measured seconds. Correlations...
Many evolutionary multi-objective optimization (EMOs) methodologies have been proposed and shown a great potential in approximating the entire Pareto front. While real world, what decision makers (DMs) want is one or several solutions to satisfy their requirements. It has become hot problem that dynamically using preference information provided by DMs during process guides search of EMO algorithms. An interactive reference region-based algorithm through decomposition proposed, denoted as...
Abstract Previous studies have debated whether the ability for bilinguals to mentally control their languages is a consequence of experiences switching between or it specific, yet highly‐adaptive, cognitive ability. The current study investigates how variations in language‐related gene FOXP2 and executive function‐related genes COMT, BDNF, Kibra/WWC1 affect bilingual language during two phases speech production, namely schema phase (i.e., selection one another) lexical response utterance...
Aims: SUMOylation is a post-translational modification that plays crucial role in the cellular stress response. We aimed to demonstrate whether and how SUMO E2 conjugation enzyme Ubc9 affects acute myocardial ischemic (MI) injury. Methods Results: Adenovirus expressing was administrated by multipoint injection border zone of heart immediately after MI C57BL/6 mice. Neonatal rat cardiomyocytes (NRCMs) were also infected, oxygen glucose deprivation (OGD) followed. In vivo, adenovirus-injected...
Abstract Compound words consist of two or more which combine to form a single word phrase that acts as one. In English, the head compound is usually, but not always, right-most root (e.g., “paycheck” noun because head, “check,” noun). The current study explores effects position on language control by examining switching performance through electroencephalography (EEG). Twenty-one pairs Chinese (L1)–English (L2) bilinguals performed cued in simultaneous production and comprehension task....
The selling price of a used car can be predicted based on its historical information. Accurate and reasonable evaluation will able to promote the healthy progress industry. Current prediction models are troubled by data quality inability provide estimates uncertain information, accuracy cannot meet needs real-world scenarios. In this work, we propose model Bayesian neural networks with latent factor (LFBNN) in cloud platform, which is capable performing extraction operations structured cars...
Summary Clinical treatment of Candida albicans infections has become more difficult due to the limited development antifungal agents and rapid emergence drug resistance. In this study, we demonstrate synthesis a series piperazine derivatives evaluation their inhibitory activity against C. virulence. Thirty‐four (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives, including 25 new compounds, were synthesized assessed for efficacy physiology pathogenesis . Several compounds strongly...
Colorectal cancer (CRC) is one of the leading causes death worldwide, with most mortalities being caused by metastases. However, underlying molecular mechanism CRC metastases remains largely unknown. Emerging evidence has shown role tripartite motif family, especially protein 6 (TRIM6), in carcinogenesis. In this study, we used cell lines TRIM6 knockdown and overexpression to investigate function metastasis. We found that promotes migration invasion both vitro vivo . slows down processes,...
Abstract Objectives Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(−)-NAF) used as racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF pooled human liver microsomes (HLMs) cytochrome P450 isozymes (CYPs) involved their metabolism. Methods Metabolism studies were conducted vitro using HLMs. Specific chemical inhibitors recombinant CYPs confirm that contributed enantiomers. Key findings Three metabolites found characterized...
Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention prostate cancer in elderly men. These patients receive a combination drugs, which involves high risk drug-drug interaction. exhibits superior efficacy but must be administered at much higher dosage than other therapeutic drugs. We previously showed that extensive glucuronidation naftopidil enantiomers caused poor bioavailability. However, metabolic pathway mechanism action enantiomer remain to...
In an inertial navigation system, especially in a pedestrian dead-reckoning gyroscope bias can demonstrably reduce positioning accuracy. A novel estimation algorithm is proposed, which estimates the of under any set angle observations. Moreover, method for obtaining Euler angles using map corridor information proposed. The heading obtained from used to estimate bias, and estimated correct trajectories. Experimental results show that it feasible gyroscope.
Abstract Candida albicans is an important human fungal pathogen. Our previous study disclosed that aryloxy‐phenylpiperazine skeleton was a promising molecule to suppress C. virulence by inhibiting hypha formation and biofilm formation. In order deeply understand the efficacy mechanism of action phenylpiperazine compounds, obtain new derivatives with excellent activity against , hence, we synthesized three series (1‐heteroaryloxy‐2‐hydroxypropyl)‐phenylpiperazines evaluated their inhibitory...