A5101710597- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Gut microbiota and health
- Diet and metabolism studies
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Animal Nutrition and Physiology
- Plant Pathogenic Bacteria Studies
- Mycorrhizal Fungi and Plant Interactions
- Probiotics and Fermented Foods
- Marine and coastal ecosystems
- Microbial Community Ecology and Physiology
- Rabbits: Nutrition, Reproduction, Health
- Infant Nutrition and Health
- Ruminant Nutrition and Digestive Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Sesquiterpenes and Asteraceae Studies
- Food composition and properties
- Bacterial biofilms and quorum sensing
- Oral microbiology and periodontitis research
- Agriculture Sustainability and Environmental Impact
- Prenatal Screening and Diagnostics
- Natural product bioactivities and synthesis
- Clinical Nutrition and Gastroenterology
Southern Medical University
2018-2025
Chinese Academy of Sciences
2008-2024
University of Illinois Urbana-Champaign
2018-2024
Xinjiang Technical Institute of Physics & Chemistry
2010-2024
Nanjing Institute of Environmental Sciences
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
Ministry of Ecology and Environment
2021-2024
Shandong Freshwater Fisheries Research Institute
2024
Zhejiang Gongshang University
2022-2024
Fudan University
2024
A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide (1), a alkaloid, terremide C (2), aromatic butenolide, aspernolide E (3), together with 10 known compounds were isolated from the fermentation broth of marine-derived fungus Aspergillus terreus SCSGAF0162. Their structures elucidated by spectroscopic analysis, absolute configuration 1 was determined Mosher ester technique analysis acid hydrolysates using chiral-phase HPLC column. Compound contains rare 3-OH-N-CH3-Phe residue...
Abstract Cyhalothrin is a common environmental pollutant which poses increased risks to non-target organisms including human beings. This study reported for the first time newly isolated strain, Bacillus thuringiensis ZS-19 completely degraded cyhalothrin in minimal medium within 72 h. The bacterium transformed by cleavage of both ester linkage and diaryl bond yield six intermediate products. Moreover, novel degradation pathway strain was proposed on basis identified metabolites. In addition...
Arbuscular mycorrhizal (AM) fungi colonize roots improving plant water status and tolerance to drought. However, it is not clear whether the presence of AM would affect photosynthesis antioxidant gene-enzymes response, which help alleviate drought stress host plant. Here, pot experiments were performed investigate effects Rhizophagus irregularis, an fungus, on tissue content, photosynthesis, reactive oxygen species (ROS) production, enzyme activity gene expression in black locust (Robinia...
Significance Many bacteria sense their population density by a process called quorum sensing (QS). In addition, individual bacterial cells chemical and physical environment adjusting levels of the intracellular compound cyclic diguanosine monophosphate (c-di-GMP). Here, we show that RpfR, QS signal receptor protein from pathogenic bacterium Burkholderia cenocepacia , forms complex with c-di-GMP regulator named GtrR. This is not proficient to activate expression virulence genes. However, upon...
Two new dihydrothiophene-condensed chromones and a natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from culture broth of marine-derived fungus, Penicillium oxalicum. The structures 1-3 acetylated derivatives 1 (4-7) elucidated on the basis spectroscopic methods chemical reactions. absolute configuration 2 established by using modified Mosher ester method circular dichroism data an in situ formed [Rh2(OCOCF3)4] [Mo2(OAc)4] complex. (R)-MTPA showed cytotoxicity...
Abstract Ralstonia solanacearum is an important bacterial pathogen that can infect a broad range of plants worldwide. A previous study showed R. could respond to exogenous organic acids or amino modulate cell motility. However, it was unclear whether uses these compounds control infection. In this study, we found GMI1000 host plant metabolites enhance the biosynthesis virulence factors. We demonstrated l ‐glutamic acid from key active component associated with increased extracellular...
Abstract Prebiotics and dietary fibers are nondigestible ingredients that may confer benefits to the host by selectively stimulating beneficial intestinal bacteria microbial-derived metabolites support gut health. This experiment evaluated effects of a blend prebiotics on apparent total tract digestibility (ATTD) fecal related gastrointestinal health in adult dogs. Four diets containing either 5% cellulose (control; CT), fiber prebiotic (FP), 0.02% saccharin eugenol (SE), or plus (FSE) were...
Abstract Objectives The SOX5 gene has been identified as the pathogenic responsible for Lamb-Shaffer syndrome. In this study, we examined variant (c.221C > T, p.Thr74Met) within a Chinese family presenting with intellectual disability and evaluated functional implications of by in vitro experiment. Materials methods underwent clinical assessment development, which included precise exome sequencing to identify causative genetic variants. potential deleterious effects pathogenicity were...
Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3–9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 2 elucidated by extensive 1D 2D NMR mass spectroscopic data. All evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP prostate B16F10 mouse melanoma cells. Compound 6 showed significant activity cell lines IC50 values 0.62 2.78 μM, respectively. Further...
Summary Dickeya zeae is a causal agent of rice root rot disease. The pathogen known to produce range virulence factors, including phytotoxic zeamines and extracellular enzymes, but the mechanisms regulation remain vague. In this study, we identified SlyA/MarR family transcription factor SlyA in D. strain EC1. Disruption slyA significantly decreased zeamine production, enhanced swimming swarming motility, reduced biofilm formation pathogenicity on rice. Quantitative polymerase chain reaction...
Diffusible signal factor (DSF) represents a new class of widely conserved quorum sensing signals, which regulates various biological functions through intra- or interspecies signaling. The previous studies identified that there is an antagonistic interaction between Xanthomonas and Bacillus species bacteria in natural ecosystem, but the detailed molecular mechanism competition not clear. This study showed campestris pv. (Xcc) interfered with morphological transition sporulation thuringiensis...
Sugarcane smut is a fungal disease caused by Sporisorium scitamineum, which can cause severe economic losses in sugarcane industry. The infection depends on the mating of bipolar sporida to form dikaryon and develops into hyphae penetrate meristematic tissue sugarcane. In this study, we set isolate bacterial strains capable blocking evaluate their potential control disease. A ST4 from rhizosphere displayed potent inhibitory activity against S. scitamineum was selected for further study....
Summary Quorum sensing (QS) is widely utilized by bacterial pathogens to regulate biological functions and pathogenicity. Recent evidence has shown that QS subject regulatory cascades, especially two‐component systems often respond environmental stimulation. At least two different types of pathogenesis in Burkholderia cenocepacia . However, it remains unclear how this pathogen controls these systems. Here, we demonstrate a novel system RqpSR ( R egulating Q uorum P athogenicity), which plays...
Five new chromone derivatives, arthones A–E (1–5), together with eight known biogenetically related cometabolites (6–13), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. Their structures assigned by detailed analyses of spectroscopic data, while the absolute configurations 1 and 5 established electronic circular dichroism (ECD) calculations that 2 was determined modified Mosher ester method. Compounds 3 8 exhibited potent antioxidant property DPPH ABTS radical...
Abstract Periodontal disease (PD) is the most common clinical condition occurring in adult dogs. The objective of this study was to evaluate benefits daily dental chew administration on oral health outcomes Twelve (mean age = 5.31 ± 1.08 yr; mean BW 13.12 1.39 kg) female beagle dogs were used a replicated 4 × Latin square design consisting 28-d periods. On day 0 each period, teeth cleaned by veterinary dentist blinded treatments. Teeth then scored for plaque, calculus, and gingivitis same 28...