A5034961174- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Immune cells in cancer
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Cerebrovascular and genetic disorders
- Cancer-related gene regulation
- Acute Kidney Injury Research
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Connective Tissue Growth Factor Research
Westmead Institute for Medical Research
2016-2025
The University of Sydney
2016-2025
Shanxi Medical University
1996-2025
Second Hospital of Shanxi Medical University
2022-2025
Shaoxing Second Hospital
2015-2025
Affiliated Hospital of Guangdong Medical College Hospital
2025
Guangdong Medical College
2025
Westmead Institute
2005-2024
Nanjing University of Chinese Medicine
2024
Metabolism and Renal Physiology
2014-2024
Recent studies have demonstrated that mesenchymal stem cells (MSCs) modulate the immune response and reduce lung injury in animal models. Currently, no clinical of effects MSCs acute respiratory distress syndrome (ARDS) exist. The objectives this study were first to examine possible adverse events after systemic administration allogeneic adipose-derived ARDS patients second determine potential efficacy on ARDS. Twelve adult meeting Berlin definition with a PaO2/FiO2 ratio < 200 randomized...
Two types of alternatively activated macrophages, M(2a) induced by IL-4/IL-13 and M(2c) IL-10/TGF-β, exhibit anti-inflammatory functions in vitro protect against renal injury vivo. Since their relative therapeutic efficacy is unclear, we compared the effects these two macrophage subsets murine adriamycin nephrosis. Both significantly reduced inflammation injury; however, macrophages more effectively glomerulosclerosis, tubular atrophy, interstitial expansion, proteinuria than macrophages....
IL-10/TGF-β–modified macrophages, a subset of activated produce anti-inflammatory cytokines, suggesting that they may protect against inflammation-mediated injury. Here, macrophages modified ex vivo by IL-10/TGF-β (IL-10/TGF-β Μ2) significantly attenuated renal inflammation, structural injury, and functional decline in murine adriamycin nephrosis (AN). These cells deactivated effector inhibited CD4+ T cell proliferation. Μ2 expressed high levels the regulatory co-stimulatory molecule B7-H4,...
Macrophages have heterogeneous phenotypes and complex functions within both innate adaptive immune responses. To date, most experimental studies been performed on macrophages derived from bone marrow, spleen peritoneum. However, differences among these particular sources remain unclear. In this study, the features of murine peritoneum were compared. We found that peritoneal (PMs) appear to be more mature than marrow (BMs) splenic (SPMs) based their morphology surface molecular...
Objectives: The goal of this study was to determine the role microRNA transfer in mediating effects mesenchymal stem cell–derived extracellular vesicles acute lung injury. Design: Experimental cell and animal studies. Setting: University-based research laboratory. Subjects: THP-1 monocytes, bone marrow–derived macrophages, C57BL/6 mice. Interventions: To vitro, cells were cultured with macrophages then assayed for expression target cells. examine vivo, administered mice...
Old age is a known risk factor for mortality in acute respiratory distress syndrome (ARDS)/acute lung injury. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties, while aging MSCs have reduced capacity. Recent studies demonstrated that MSC-derived extracellular vesicles (MSC-EVs) are able to mimic alleviating The goals of this study were determine whether EVs from young and had differential effects on lipopolysaccharide (LPS)-induced injury mice unravel the underlying...
The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative importance of this immune pathway for immunotherapy against inflammation damage remains unclear. Here, we show that treatment with recombinant mouse IL-33 prevented renal structural functional injury reduced mortality mice subjected to ischemia-reperfusion (IRI). Compared control-treated IRI mice, IL-33–treated had increased levels IL-4 IL-13...
Studies of mechanisms disease regulation by CD4+CD25+ regulatory T cells (Treg) have been focused on their interaction with effector cells; however, the possibility that might involve noncognate has not explored in detail. This study investigated effect Treg macrophage proinflammatory properties and phenotype vitro found they modulate macrophages inhibiting activation, leading to reduced cytokine production a downregulated phenotype. For testing vivo significance this effect, expressed high...
Conventional markers of macrophages (Mфs) and dendritic cells (DCs) lack specificity often overlap, leading to confusion controversy regarding the precise function these in kidney other diseases. This study aimed identify phenotype renal mononuclear phagocytes (rMPs) expressing key both Mфs DCs. F4/80+CD11c+ accounted for 45% total rMPs normal kidneys those from mice with Adriamycin nephropathy (AN). Despite expression DC marker CD11c, double-positive displayed features Mфs, including...
<i>Background:</i> Alternatively activated macrophages (M2 macrophages) are able to reduce renal injury in murine adriamycin nephropathy. However, the effect of M2 other diseases such as diabetic nephropathy remains unknown. <i>Methods:</i> Macrophages were separated from splenocytes and polarized with IL-4 IL-13 into a protective phenotype. Mice underwent adoptive transfer macrophages, then diabetes was induced by tail vein injection streptozotocin (STZ). Blood...
TGF-β is a key profibrotic factor, but targeting to prevent fibrosis also abolishes its protective anti-inflammatory effects. Here, we investigated the hypothesis that can redirect signaling by preventing downstream interaction of β-catenin with T cell factor (TCF), thereby enhancing Foxo, transcription controls differentiation induced regulatory cells (iTregs), and thus, enhance effects In iTregs derived from EL4 treated recombinant human TGF-β1 (rhTGF-β1) in vitro, inhibition β-catenin/TCF...
Abstract Background Atherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation, endothelial dysfunction macrophages infiltration. Nobiletin (NOB) has been reported to alleviate atherosclerosis; however, the underlying mechanism remains incompletely understood. Methods This study involved comprehensive bioinformatic analysis, multidatabase target prediction; GO KEGG enrichment analyses for function pathway exploration;...
The kidney contains receptors for the cytokine IL-25, but effects of IL-25 in CKD are unknown. Here, we induced adriamycin nephropathy both BALB/c mice and severe combined immunodeficient (SCID) mice, injected 7 consecutive days starting at day 5 after administration. treated with had less glomerulosclerosis, tubular atrophy, interstitial expansion, proteinuria than control 28. increased levels IL-4 IL-13 serum, kidney, renal draining lymph nodes, CD4+ lymphocytes. also directly suppressed...