A5030561871- Renal and related cancers
- Immune Cell Function and Interaction
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Healthcare Systems and Reforms
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Renal Diseases and Glomerulopathies
- Health Systems, Economic Evaluations, Quality of Life
- Hematological disorders and diagnostics
- T-cell and B-cell Immunology
- Healthcare cost, quality, practices
- Complement system in diseases
- Immunotherapy and Immune Responses
- Parathyroid Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Renal cell carcinoma treatment
- Pharmaceutical Economics and Policy
- Organ Donation and Transplantation
- Transcranial Magnetic Stimulation Studies
- Biomedical Research and Pathophysiology
- Acute Kidney Injury Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Magnesium in Health and Disease
The University of Sydney
2018-2025
Westmead Institute for Medical Research
2018-2025
Westmead Hospital
2014-2024
Beijing Normal University - Hong Kong Baptist University United International College
2023
Beijing Normal University
2023
Hong Kong Baptist University
2023
RELX Group (United States)
2022
Metabolism and Renal Physiology
2018
Liverpool Hospital
2015-2016
Australian National University
2010
The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative importance of this immune pathway for immunotherapy against inflammation damage remains unclear. Here, we show that treatment with recombinant mouse IL-33 prevented renal structural functional injury reduced mortality mice subjected to ischemia-reperfusion (IRI). Compared control-treated IRI mice, IL-33–treated had increased levels IL-4 IL-13...
Essential medicines are defined as those that "satisfy the priority health care needs of population" and selected with due regard to public relevance based on their efficacy, safety, comparative cost-effectiveness.1World Health Organization The Selection Use Medicines. Report WHO Expert Committee (Including 12th Model List Medicines). WHO, 2003Google Scholar They intended be accessible within context functioning systems in adequate quantities, appropriate dosage forms, ensured quality...
Renal Cell Carcinoma (RCC) poses challenges for conventional treatment methods, but recent advancements indicate the potential of nanoparticles (NPs) in enhancing chemotherapy efficacy. This study focuses on developing non-toxic NPs from sucrose and l-serine via hydrothermal synthesis to produce Sucrose Carbon Dots (Suc CDs), designed renal clearance deliver hydrophilic drugs RCC. Suc CDs with a size 4 nm exhibit high fluorescence quantum yield 58% drug loading capacity without toxicity...
Dialysis patients have an exceedingly high mortality rate. Biomarkers may be useful tools in risk stratification of this population. We evaluated the prognostic value high-sensitivity cardiac troponin T (hs-cTnT) and CRP (C-reactive protein) predicting adverse outcomes stable hemodialysis peritoneal dialysis (PD) patients. Variability hs-cTnT was also examined.
Transforming growth factor β (TGF-β) is the key cytokine involved in causing fibrosis through cross-talk with major profibrotic pathways. However, inhibition of TGF-β to prevent would also abrogate its anti-inflammatory and wound-healing effects. β-catenin a common co-factor most signaling binds T-cell (TCF) activate genes Forkhead box O (Foxo) promote cell survival under oxidative stress. Using proximity ligation assay human kidney biopsies, we found that β-catenin/Foxo interactions were...
Abstract Background Chronic kidney disease (CKD) is a global public health problem, which lacks effective treatment. Previously, we have shown that CD103+ dendritic cells (DCs) are pathogenic in adriamycin nephropathy (AN), model of human focal segmental glomerulosclerosis (FSGS). Fms-like tyrosine kinase 3 (Flt3) receptor expressed with high specificity on tissue resident DCs. Methods To test the effect DCs and injury inhibition Flt3, used selective Flt3 inhibitor (AC220) to treat mice AN....
Fibrosis is characterized by progressively excessive deposition of matrix components and may lead to organ failure. Transforming growth factor-β (TGF-β) a key cytokine involved in tissue repair fibrosis. TGF-β's profibrotic signaling pathways converge at activation β-catenin. β-Catenin an important transcription cofactor whose function depends on its binding partner. Promoting β-catenin forkhead box protein O (Foxo) via inhibition T-cell factor (TCF) reduces kidney fibrosis experimental...
β-Catenin is an important co-factor which binds multiple transcriptional molecules and mediates fibrogenic signaling pathways. Its role in kidney transplantation unknown. We quantified binding of β-catenin within renal tubular epithelial cells to transcription factors, TCF1 FoxO1, using a proximity ligation assay 240 transplanted kidneys, evaluated their pathological clinical outcomes. β-Catenin/FoxO1 1-month protocol biopsies inversely correlated with contemporaneous chronic fibrosis,...
Background cDC1 is a subset of conventional DCs, whose most recognized function cross-presentation to CD8 + T cells. We conducted this study investigate the number and location cDC1s in various human kidney diseases as well their correlation with clinico-pathological features Methods analyzed 135 biopsies samples. Kidney included: acute tubular necrosis (ATN), interstitial nephritis (AIN), proliferative glomerulonephritis (GN) (IgA nephropathy, lupus nephritis, pauci-immune GN, anti-GBM...
Although type 2 innate lymphoid cells (ILC2s) were originally found to be liver-resident lymphocytes, the role and importance of ILC2 in liver injury remains poorly understood. In current study, we sought determine whether is an important regulator hepatic ischaemia/reperfusion (IRI).ILC2-deficient mice (ICOS-T or NSG) genetically modified ILC2s used investigate murine IRI. Interactions between eosinophils macrophages studied coculture. The human was assessed immunocompromised mouse model...
In Non-Hodgkin Lymphoma (NHL), bone marrow histology is the gold standard against which ancillary investigations such as immunophenotyping and gene rearrangement studies are interpreted. There currently no data on reproducibility of histological findings. This study was conducted to determine rates inter- intra-observer agreement in detection involvement two major subtypes NHL, Diffuse Large B-cell (DLBCL), Follicular (FL).The slides randomly selected DLBCL FL cases were independently...
Introduction: Lanthanum carbonate (LC) and sevelamer hydrochloride (SH) are non-calcium-based phosphate binders (NCPB), used to manage hyperphosphatemia in patients with chronic kidney disease. We compared the efficacy of LC SH lowering serum level on haemodialysis or continuous ambulatory peritoneal dialysis. Methods: Treatment profiles a group dialysis NCPB were retrospectively analyzed between 2010 2014 for mean duration one year. The treatment included (n = 28) who initially switched...