A5100714386- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Chromosomal and Genetic Variations
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- RNA modifications and cancer
- Food Allergy and Anaphylaxis Research
- Adipose Tissue and Metabolism
- Space Satellite Systems and Control
- Inertial Sensor and Navigation
- Protease and Inhibitor Mechanisms
- Inflammatory mediators and NSAID effects
- GNSS positioning and interference
- Mesenchymal stem cell research
- Chronic Kidney Disease and Diabetes
- Gout, Hyperuricemia, Uric Acid
University of Shanghai for Science and Technology
2020-2025
Chinese PLA General Hospital
2015-2024
South Dakota State University
2020-2024
Southeast University
2024
Beihang University
2006-2024
Nanjing Sport Institute
2023
Shanghai Jiao Tong University
2008-2023
University of North Carolina at Chapel Hill
2003-2023
Hainan Normal University
2019-2023
First Affiliated Hospital Zhejiang University
1995-2023
Human adipose-derived mesenchymal progenitor cells (haMPCs) are stem with multiple differentiation potential and immunomodulatory function. Re-Join® comprises in vitro expanded haMPCs from adipose tissue of patients combined cell suspension solution. This study was undertaken to evaluate the efficacy safety symptomatic knee osteoarthritis (OA). Patients Kellgren–Lawrence grade 1–3 OA were recruited two centers randomized receive intra-articular injection or HA. Pain function assessed by...
Cardiac troponin is the preferred biomarker for diagnosis of acute myocardial infarction (AMI). The recent development a high-sensitive cardiac T (hs-cTnT) assay permits detection very low levels cTnT. Using hs-cTnT improves overall diagnostic accuracy in patients with suspected AMI, while negative result also has high predictive value. gain sensitivity may be particularly important short duration from symptom onset to admission. Measurement provide strong prognostic information coronary...
Background MicroRNA (miRNA) has been found in human blood. It increasingly suggested that miRNAs may serve as biomarkers for diseases. We examined the potential of circulating miRNA to predictors atrial fibrillation (AF). Methodology/Principal Findings During discovery stage this project, we used massively parallel signature sequencing (MPSS) carry out an in-depth analysis expression profile (miRNome) 5 healthy controls, patients with paroxysmal (PAF) alone, and persistent (PersAF) alone....
Diabetic cardiomyopathy (DCM) is a common complication of diabetes and characterized by chronic myocardial inflammation. Mesenchymal stem cell (MSC) infusions have recently been suggested to alleviate injury ameliorate cardiac function. However, few studies focused on the effects MSCs in DCM. Therefore, we explored MSC-regulated macrophage polarization repair
Long interspersed element type 1 (L1) retrotransposons are ubiquitous mammalian mobile elements and potential tools for in vivo mutagenesis; however, native L1 relatively inactive mice when introduced as transgenes. We have previously described a synthetic element, ORFeus, containing two synonymously recoded ORFs relative to mouse L1. It is significantly more active retrotransposition cell culture than all tested. To study its activity vivo, we developed transgenic model which ORFeus...
Evidence from experimental studies suggests that fetal exposure to the endocrine-disrupting chemical bisphenol A (BPA) has adverse reproductive effects in both males and females. Studies our laboratory suggest developing female fetus produces a unique, multigenerational effect. Specifically, maternal affects earliest stages of oogenesis ovary, resulting subtle meiotic defects increase likelihood embryos produced by exposed adulthood (i.e., grandchildren) will be chromosomally abnormal. To...
We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from CSPPT (China Stroke Primary Prevention Trial), double-blind, randomized controlled trial.A 20 702 hypertensive adults without history major cardiovascular disease were randomly assigned double-blind daily treatment an enalapril 10-mg and 0.8-mg tablet or alone. The primary outcome was stroke.The median...
Abstract Background Diabetic cardiomyopathy (DCM) is a cardiac complication of long-term uncontrolled diabetes and characterized by myocardial fibrosis abnormal function. Mesenchymal stem cells (MSCs) are multipotent with immunoregulatory secretory functions in heart diseases. However, very few studies have focused on the effect underlying mechanism MSCs DCM. Therefore, we aimed to explore therapeutic potential its vivo vitro. Methods A DCM rat model was induced using high-fat diet (HFD)...
Abstract This study aims to explore the recurrence rate and overall survival for patients with cervical cancer after first treatment related risk factors. A retrospective cohort was conducted on enrolled in a specialist hospital Hunan Province, China from January 1992 December 2005 followed up until 2010. Kaplan–Meier analysis used estimate cumulative rate, Cox proportional hazards model utilized identify factors associated prognosis. total of 4358 were median follow-up 7.4 years (range 5–19...
Renal Cell Carcinoma (RCC) poses challenges for conventional treatment methods, but recent advancements indicate the potential of nanoparticles (NPs) in enhancing chemotherapy efficacy. This study focuses on developing non-toxic NPs from sucrose and l-serine via hydrothermal synthesis to produce Sucrose Carbon Dots (Suc CDs), designed renal clearance deliver hydrophilic drugs RCC. Suc CDs with a size 4 nm exhibit high fluorescence quantum yield 58% drug loading capacity without toxicity...
Cardiac fibrosis is the primary cause of deteriorated cardiac function in various cardiovascular diseases. Numerous studies have demonstrated that microRNAs (miRNAs) are critical regulators myocardial fibrosis. Specifically, many reported miR-150 downregulated diseases, such as acute infarction (AMI), hypertrophy and However, exact role these pathological processes remains unknown.We used transverse aortic constriction (TAC) mouse model to study induced by pressure overload. After TAC...
Patients suffering from breast cancer (BC) still have a poor response to treatments, even though early detection and improved therapy contributed reduced mortality.Recent studies been inspired on the association between microRNAs (miRs) therapies of BC.The current study set out investigate role miR-216b in BC, further analyze underlining mechanism.Firstly, hexokinase 2 (HK2) were characterized BC tissues cells by RT-qPCR Western blot assay.In addition, interaction HK2 was analyzed using dual...