A5060278303- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac and Coronary Surgery Techniques
- Phagocytosis and Immune Regulation
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Aortic aneurysm repair treatments
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Endoplasmic Reticulum Stress and Disease
- Cardiac Fibrosis and Remodeling
- Cardiac tumors and thrombi
- Chemokine receptors and signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trauma Management and Diagnosis
- Natural Products and Biological Research
- Apelin-related biomedical research
- Dietary Effects on Health
- Inflammation biomarkers and pathways
Air Force Medical University
2013-2025
Xijing Hospital
2012-2025
Northwest University
2022
The objective of this study was to evaluate the safety and efficacy surgical versus transcatheter approach correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial.pmVSD is common congenital heart disease children. Surgical closure pmVSD well-established therapy but requires open-heart surgery with cardiopulmonary bypass. Although associated significant incidence complete atrioventricular block, it may provide less invasive...
Abstract Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, biological cardiac-derived CTRP9 remains unclear. We hypothesize responds ischemia/reperfusion (MI/R) injury as cardiokine. explored MI/R via genetic manipulation CTRP9-knockout (CTRP9-KO) animal model. Inhibition exacerbated, whereas its overexpression...
Cardiac fibrosis is the primary cause of deteriorated cardiac function in various cardiovascular diseases. Numerous studies have demonstrated that microRNAs (miRNAs) are critical regulators myocardial fibrosis. Specifically, many reported miR-150 downregulated diseases, such as acute infarction (AMI), hypertrophy and However, exact role these pathological processes remains unknown.We used transverse aortic constriction (TAC) mouse model to study induced by pressure overload. After TAC...
ABSTRACT Ischemia reperfusion‐induced myocardial injury is a prominent pathological feature in patients with coronary artery disease, contributing to significant mortality and morbidity rates. Mangiferin (MGF), the main active ingredient extracted from Anemarrhena asphodeloides Bge , has anti‐inflammatory, anti‐oxidation, anti‐diabetes, anti‐tumor effects. The present study confirmed that GAS6/Axl pathway was identified as promising novel target for treatment of ischemia reperfusion (IR)...
To investigate the application of transesophageal echocar-diography assessment for mitral valve in patients with atrial septal defects undergoing repair surgery. Thirty-two adult defect underwent thoracoscopic surgery at First Affiliated Hospital Military Medical University PLA Air Force from March to September 2022 were collected (study group). The two-dimensional and real-time three-dimensional ultrasonography performed after anesthesia. parameters structure late diastolic systolic stages...
As a newly identified adiponectin paralog, C1q/TNF‐related protein 9 (CTRP9) reduces myocardial ischemia reperfusion (IR) injury through partially understood mechanisms. In the present study, we sought to identify role of endoplasmic reticulum stress (ERS) in CTRP9 induced cardioprotection diabetic heart. Isolated hearts from high‐fat‐diet (HFD) type 2 Sprague‐Dawley rats were subjected ex vivo IR protocol via Langendorff apparatus at presence globular CTRP9. significantly improved post‐IR...
Myocardial dysfunction is well-recognized manifestations of organ in sepsis, which the leading cause death critically ill patients. The underlying mechanisms associated with sepsis-induced myocardial injury (SIMI) include cardiac contractility, inflammatory response, oxidative stress, and apoptosis. Kudzu celery decoction (KCD) composed a variety traditional Chinese medicine (TCM) such as kudzu celery. previous study found that main ingredients have also been proved to anti-inflammatory,...
The present study was designed to investigate the effect of κ-opioid receptor stimulation with U50,488H on endothelial function and underlying mechanism in rats hypoxic pulmonary hypertension (HPH). Chronic hypoxia-induced HPH simulated by exposing 10% oxygen for 2 wk. After hypoxia, mean arterial pressure (mPAP), right ventricular (RVP) hypertrophy index (RVHI) were measured. Relaxation artery response acetylcholine (ACh) determined. Expression activity nitric oxide (NO) synthase (eNOS)...
Impairment of pulmonary endothelium function in the artery is a direct result chronic hypoxia. This study to investigate vasculoprotective effects U50,488H (a selective κ-opioid receptor agonist) and its underlying mechanism hypoxia-induced endothelial functional injury. Chronic hypoxia was simulated by exposing rats 10% oxygen for 2 wk. After hypoxia, right ventricular pressure (RVP) hypertrophy index (RVHI) were measured. The vascular dysfunction, effect nitric oxide synthase inhibitor...
<p>The purpose of this study is to compare early clinical outcomes surgical repair for isolated atrial septal defect (ASD) with a totally thoracoscopic approach without robotic assistance versus conventional open procedure.</p><p>Between September 2010 and June 2012, 254 consecutive patients ASD underwent surgery in seven institutions participating the nationwide multi-centered registry China. During same period, these were matched using propensity score methodology who had...