A5101757840- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Vitamin C and Antioxidants Research
- Nanoparticle-Based Drug Delivery
- Healthcare and Venom Research
- Free Radicals and Antioxidants
- Psoriasis: Treatment and Pathogenesis
- Lymphatic System and Diseases
- RNA Interference and Gene Delivery
- Aldose Reductase and Taurine
- Inflammation biomarkers and pathways
- Hops Chemistry and Applications
- Salivary Gland Disorders and Functions
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Heme Oxygenase-1 and Carbon Monoxide
- Biochemical Acid Research Studies
- Alkaloids: synthesis and pharmacology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Childhood Cancer Survivors' Quality of Life
- Bioactive Compounds and Antitumor Agents
- Caveolin-1 and cellular processes
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Shanxi Agricultural University
2024
China Medical University
2009-2024
China National Institute of Standardization
2019-2024
First Hospital of China Medical University
2024
Shandong University of Traditional Chinese Medicine
2018-2024
Xijing Hospital
2022-2023
Air Force Medical University
2022-2023
Shandong First Medical University
2019-2022
Magnetic resonance imaging (MRI) contrast agents with high relaxivity are highly desirable because they can significantly increase the accuracy of diagnosis. However, be potentially toxic to patients. In this study, using a mouse model, we investigate effects and subsequent tissue damage induced by three T1 MRI agents: gadopentetate dimeglumine injection (GDI), clinically used gadolinium (Gd)-based agent (GBCAs), oxide nanoparticle (NP)-based agents, extremely small-sized iron NPs (ESIONs)...
The aim of the present study was to investigate protective effects (−)-epigallocatechin-3-gallate (EGCG), main polyphenolic constituent green tea, in aging mice induced by D-galactose (D-gal). model subcutaneous (s.c.) injection D-gal (150 mg/kg) once daily for 6 weeks. EGCG (2 mg/kg or administered intragastrically (i.g.) 4 weeks after 2-week injection. water maze test used evaluate learning and memory function mice. activities total superoxide dismutase (T-SOD) glutathione peroxidase...
Inflammation has a recognized role in nonalcoholic fatty liver disease (NAFLD) progression. In the present work, we studied effect of high-fat diet (HFD) on arachidonic acid metabolism and investigated farnesoid X receptor (FXR, NR1H4) eicosanoid biosynthetic pathways nuclear factor <i>κ</i> light-chain enhancer activated B cells (NF-kB) signaling, major modulators inflammatory cascade. Mice were fed an HFD to induce NAFLD then treated with FXR ligand obeticholic (OCA). Histology gene...
Abstract Exosomes are vesicles with sizes ranging from 30 to 150 nm. The analysis and detection of blood exosomes offers an effective route for cancer diagnosis, prognosis assessment, therapeutic evaluation diseases. Due the difference in separation procedure, collection method usage anticoagulants, serum plasma samples show diversity test results. In order evaluate isolation effect samples, two commonly used exosomal methods, ultracentrifugation polymer‐based precipitation kit, were used,...
Neuropathic pain is a complex condition that usually lasts lifetime and has major negative impact on life after injury. Improving management an important unmet need. Astaxanthin (AST) natural marine medicine with effective antioxidant anti-inflammatory properties neuroprotective effects. However, few mechanisms can explain the role of AST in treatment neuropathic pain. In present study, we examined its potential to eliminate spinal nerve ligation (SNL) damage by inhibiting phosphorylation...
Fibromyalgia is characterised by widespread chronic pain and often accompanied comorbidities such as sleep disorders, anxiety, depression. Because it many adverse symptoms lack of effective treatment, important to search for the pathogenesis treatment fibromyalgia. Astaxanthin, a carotenoid pigment known its anti-inflammatory antioxidant properties, has demonstrated analgesic effects in neuropathic pain. However, impact on fibromyalgia remains unclear. Therefore, this study, we constructed...
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Myocardial dysfunction is well-recognized manifestations of organ in sepsis, which the leading cause death critically ill patients. The underlying mechanisms associated with sepsis-induced myocardial injury (SIMI) include cardiac contractility, inflammatory response, oxidative stress, and apoptosis. Kudzu celery decoction (KCD) composed a variety traditional Chinese medicine (TCM) such as kudzu celery. previous study found that main ingredients have also been proved to anti-inflammatory,...
Deep vein thrombosis (DVT) is a common peripheral vascular disease. Secondary pulmonary embolism (PE) caused by DVT leads to substantial patient death. Inflammation has been suggested as key factor in the pathophysiology of DVT, however, involvement pyroptosis-related inflammatory factors formation remains unclear. Here, we proposed that post-transcriptional modification caspase-1 might be crucial trigger for enhanced pyroptosis endothelial cells (VECs), and consequently contributed severer...
Inflammatory pain is a complex process that has substantial negative impact on post-injury quality of life. Astaxanthin (AST), which lipid-soluble red-orange carotenoid found in lobsters, inhibits the development and maintenance inflammation mice via its antioxidant anti-inflammatory activities. However, specific mechanisms underlying these effects remain unclear. In this study, we aimed to elucidate mechanism by astaxanthin alleviated using mouse model with Complete Freund's adjuvant...
To tune the efficiency of oxidized cofactor recycling between alcohol dehydrogenase (ADH) and NADH oxidase (NOX) for production aromatic chiral alcohols, we designed constructed four novel bifunctional fusion proteins composed thermostable ADH NOX from Thermococcus kodakarensis KOD1. was linked to N- or C-terminus with a typical rigid linker (EAAAK)3 flexible (GGGGS)3 , respectively. Compared parental enzymes, moieties in exhibited higher specific activities (141%-282%), while varying levels...
Abstract Antibodies are proteins secreted by plasma cells of the immune system to bind antigens and trigger effector activity. Genetic engineering antibodies novel recombinant antibody molecules with improved antigen specificities functions, which produced DNA protein technologies. The ability produce that directed against specific drives scientific discovery development clinical diagnosis therapy. This paper provides an overview current studies on principle, categories, generation...
Bacillus Calmette-Guerin extract (BCGE) has been proven to be clinically effective for anaphylactic disease, infectious diseases and cancer. In this study, we investigated the effect of intramuscular application BCGE on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). We established an AD model in BALB/c mice by repeated local exposure DNCB ear dorsal skin. Following BCGE, thickness, mast cell infiltration, serum total immunoglobulin E (IgE) histamine level were measured....
Abstract Heparinases, including heparinases I–III (HepI, HepII, and HepIII, respectively), are important tools for producing low‐molecular‐weight heparin, an improved anticoagulant. The poor thermostability of significantly hinders their industrial laboratory applications. To improve the heparinases, we applied a rigid linker (EAAAK) 5 (R) flexible (GGGGS) (F) to fuse maltose‐binding protein (MBP) HepI, HepIII from Pedobacter heparinus , replacing original plasmid pMAL‐c2X. Compared with...