A5100422575- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Natural Compound Pharmacology Studies
- Synthesis of Organic Compounds
- Cancer Genomics and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Pluripotent Stem Cells Research
- PARP inhibition in cancer therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- CAR-T cell therapy research
- RNA modifications and cancer
- Renal and related cancers
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Peking Union Medical College Hospital
2020-2025
Hebei North University
2025
The First People’s Hospital of Lianyungang
2025
Nanjing Medical University
2025
Union Hospital
2025
Jilin University
2022-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Krirk University
2024
Hodges University
2024
Our research was designed to investigate the relationship between dietary inflammatory index (DII) and risk of ocular diseases, including glaucoma, cataract, age-related macular degeneration (ARMD), diabetic retinopathy. We used National Health Nutrition Examination Survey (NHANES) data from 2005 2008 conduct this study. The correlation DII diseases examined using weighted multivariable logistic regression analysis, restricted cubic spline (RCS) plots, subgroup analysis. In total, 2885...
The major clinical side effect of the ERBB2-targeted breast cancer therapy, trastuzumab, is a decline in left ventricular ejection fraction (LVEF). Improved markers are needed to better identify patients susceptible cardiotoxicity.The NCCTG N9831 trial compared adjuvant doxorubicin and cyclophosphamide followed by either weekly paclitaxel (arm A); then trastuzumab B); or concurrent C) with HER2-positive cancer. A genome-wide association study was performed on all available DNA (N=1446). We...
ABSTRACT The RNA-dependent RNA polymerase (RdRp) of influenza A virus is a heterotrimeric complex composed the PB1, PB2, and PA subunits. interplay between host factors three subunits RdRp critical to enable viral synthesis occur in nuclei infected cells. In this study, we newly identified factor DnaJA1, member type I DnaJ/Hsp40 family, acting as positive regulator for replication. We found that DnaJA1 associates with bPB2 enhances both vivo vitro . Moreover, could be translocated from...
Alzheimer's disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although neuropathologic diagnosis AD has been established for many years, metabolic changes in diagnosed samples have not fully investigated.To elucidate potential metabolism dysregulation postmortem human brain assessed by related pathological examination.We performed untargeted and targeted metabolomics 44 tissues. The differences hippocampus between group control (NC) were...
Epileptic seizures or status epilepticus (SE) can cause hippocampal neuronal death, which has detrimental effects. Parthanatos, a new form of programmed cell is characterized by hyperactivation poly (ADP-ribose) polymerase-1 (PARP-1), excessive synthesis ADP-ribose polymer, mitochondrial depolarization, and nuclear translocation apoptosis-inducing factor, observed in various neurodegenerative disorders but rarely reported epilepsy. We aimed to investigate whether parthanatos participates the...
The decline in oocyte quality with maternal age poses significant challenges for fertility and embryonic development. Traditional methods assessing rely on invasive techniques that limit their applicability clinical research settings. In this study, we present the first application of single-cell Raman spectroscopy imaging to profile age-related metabolic changes mouse oocytes at metaphase II (MII) stage. provided high-resolution, label-free fingerprints, enabling detailed spatial mapping...
<title>Abstract</title> Lung adenocarcinoma (LUAD), the most prevalent type of non-small cell lung cancer (NSCLC), has highest incidence and mortality rates among thoracic cancers worldwide. BIRC5, a protein linked to tumor proliferation, differentiation, migration, invasion, been insufficiently studied as potential LUAD biomarker. In this study, we used bioinformatics techniques analyze LUAD-related data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases identify...
Neurodegenerative comorbidities are common and critical, yet data specific to the Chinese population remains limited. The study aims investigate prevalence associations of neuropathologic changes comorbidities, their correlation with genetics cognition in a community-dwelling autopsy cohort China. Datasets 610 participants were obtained from National Human Brain Bank for Development Function at Academy Medical Sciences/Peking Union College. Neuropathological analysed included Alzheimer's...
Abstract The microenvironment of the central nervous system is highly complex and plays a crucial role in maintaining function neurons, which influences Alzheimer’s disease (AD) progression. pH value brain critical aspect regulating various physiological processes. However, specific mechanisms this mechanism are not yet fully understood. To better understand relationship between AD, we analyzed frontal lobe AD pathology scores postmortem samples from 368 donors National Human Brain Bank for...
The molecular mechanisms underlying cardioprotection against doxorubicin (DOX)-induced myocardial injury are poorly understood. Histone deacetylase 2 (HDAC2) plays a significant role in oxidative stress, apoptosis, and mitochondrial dysfunction is implicated many human diseases, This study investigated the relationship between HDAC2 expression DOX-induced using vivo rat model of cardiotoxicity vitro experiments with H9c2 cardiomyocytes. was established by administering DOX via...
In the current research, YouTube Addiction Scale (YAS) developed by Pakpour et al. (2023) was adapted to Turkish culture, and scale's psychometric properties were examined. A cross-sectional survey conducted with 779 adults (Mage = 25.16 years, 56% female). Confirmatory factor analysis (CFA) performed validate whether original structure of YAS retained in version. addition, tests internal consistency, concurrent validity external criterion measures (Bergen Social Media Scale, Smartphone...
The aim of this study was to explore the association systemic inflammatory biomarkers (systemic immune-inflammation (SII) index and response (SIRI)) with prevalence ocular disease in general population United States (U.S.). We conducted a cross-sectional subjects National Health Nutrition Examination Survey 2005–2008 years. For analysis SII index, SIRI (glaucoma, cataract, age-related macular degeneration (ARMD), diabetic retinopathy), restricted cubic spline (RCS) plot, multivariable...
Forward genetic screens using mammalian embryonic stem (ES) cells have identified genes required for numerous cellular processes. However, loss-of-function are more difficult to conduct in diploid because, most cases, both alleles of a gene must be mutated exhibit phenotype. Recently, haploid ES cell lines were successfully established and applied several recessive screens. all these performed mixed pools mutant mainly based on positive selection. In general, negative screening is not easy...
Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject, we aimed to reveal expression pattern clinical value ALDH3A1 in OSCC biological function lines. Materials methods: The level paired tissues adjacent noncancerous were detected by quantitative real-time PCR, Western blot immunohistochemistry. between characteristics was analyzed. Besides, cell-counting kit 8, colony...
To define how the incidence of peripheral artery disease (PAD) in chronic kidney differs according to sex and age.The Chronic Renal Insufficiency Cohort (CRIC) is a multicenter, prospective cohort study participants. Fine Gray methods were used determine cumulative PAD, defined by an ankle brachial index <0.90 or confirmed PAD event, with death as competing event. Adjusted subdistribution hazard ratios from model determined risk sex. A priori, we hypothesized that relationship between...
Abstract Background N6-methyladenosine(m6A) methylation modification affects the tumorigenesis, progression, and metastasis of breast cancer (BC). However, expression characteristics prognostic value m6A in BC are still unclear. We aimed to evaluate relationship between clinicopathological characteristics, explore underlying mechanisms. Methods Three public cohorts our clinical cohort were included: 1091 samples 113 normal from TCGA database, 1985 METABRIC 1764 KM Plotter website, 134...
ABSTRACT The noncoding regions (NCRs) of the eight-segmented viral RNAs (vRNAs) influenza A virus consist highly conserved promoter region and nonconserved segment-specific NCRs at both 3′ 5′ ends. roles eight segments have been extensively studied. However, diversities in same two subtype-determinant hemagglutinin (HA) neuraminidase (NA) received little attention. In this study, we bioinformatically analyzed all available HA NA vRNAs viruses found that nucleotides are subtype specific vary...
Amyloid beta (Aβ) plaques are one of the hallmarks Alzheimer's disease (AD). However, currently available anti-amyloid therapies fail to show effectiveness in treatment AD humans. It has been found that there different types Aβ plaque (diffuse and focal types) postmortem human brain. In this study, we aimed investigate correlations among AD-related neuropathological cognitive changes based on a brain bank China. The results indicated plaques, but not diffuse significantly increased with age...
Abstract Background It was unknown whether surgery for primary tumor would affect the occurrence of local symptoms caused by progression in patients with de novo stage IV breast cancer (BC). Our work attempted to probe effect resection on controlling and improving quality life BC patients. Methods study included presenting at Cancer Hospital Chinese Academy Medical Sciences from January 2008 December 2014. In this study, we defined a new term called “local progress/recurrence symptoms”...
Objective: The choice of chemotherapeutic regimen for triple-negative breast cancer (TNBC) remains controversial. Homologous recombination deficiency (HRD) has attracted increasing attention in informing chemotherapy treatment. This study was aimed at investigating the feasibility HRD as a clinically actionable biomarker platinum-containing and platinum-free therapy. Methods: Chinese patients with TNBC who received between May 1, 2008 March 31, 2020 were retrospectively analyzed customized...
BackgroundThe proportion of young breast cancer patients in China is significantly higher than Western countries, and the clinicopathological characteristics clinical problems faced by are different from those countries too, so there an urgent need to conduct some studies for Asia.MethodsThis study consisted two cohorts China. The population-based cohort involved cases diagnosed 2000–2017 via registration system, we describe epidemiological hospital-based cohort, eligible enrollment were...