A5079649458- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Bioinformatics
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Genetic Associations and Epidemiology
- Virology and Viral Diseases
- RNA and protein synthesis mechanisms
- Functional Brain Connectivity Studies
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Cerebrovascular and genetic disorders
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Neurogenesis and neuroplasticity mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Fractal and DNA sequence analysis
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Fudan University Shanghai Cancer Center
2024
Peking Union Medical College Hospital
2020-2024
Academy of Medical Sciences
2021-2024
Tsinghua–Berkeley Shenzhen Institute
2023-2024
China Internet Network Information Center
2023
China Academy of Chinese Medical Sciences
2023
Qingdao Academy of Intelligent Industries
2022
Robert Bosch (Germany)
2021
Laboratoire de Chimie Moléculaire et Thioorganique
2021
Abstract Motivation Mitochondria are an essential organelle in most eukaryotes. They not only play important role energy metabolism but also take part many critical cytopathological processes. Abnormal mitochondria can trigger a series of human diseases, such as Parkinson's disease, multifactor disorder and Type-II diabetes. Protein submitochondrial localization enables the understanding protein function studying disease pathogenesis drug design. Results We proposed new method,...
Neurodegenerative comorbidities are common and critical, yet data specific to the Chinese population remains limited. The study aims investigate prevalence associations of neuropathologic changes comorbidities, their correlation with genetics cognition in a community-dwelling autopsy cohort China. Datasets 610 participants were obtained from National Human Brain Bank for Development Function at Academy Medical Sciences/Peking Union College. Neuropathological analysed included Alzheimer's...
// Bin Yu 1, 2, 3, * , Shan Li Wen-Ying Qiu Cheng Chen 2 Rui-Xin Lei Wang 4 Ming-Hui and Yan Zhang 5 1 College of Mathematics Physics, Qingdao University Science Technology, 266061, China Bioinformatics Systems Biology Research Center, 3 CAS Key Laboratory Geospace Environment, Department Geophysics Planetary Science, Technology China, Hefei 230026, Eco-Chemical Engineering, Ministry Education, Inorganic Synthesis Applied Chemistry, Chemistry Molecular 266042, Electromechanical These authors...
Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. proteins subcellular localization information very important for understanding the mechanism of programmed cell death development drugs. Therefore, prediction apoptosis protein still a challenging task. In this paper, we propose novel method predicting localization, called PsePSSM-DCCA-LFDA. Firstly, sequences are extracted by combining pseudo-position...
Alzheimer's disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although neuropathologic diagnosis AD has been established for many years, metabolic changes in diagnosed samples have not fully investigated.To elucidate potential metabolism dysregulation postmortem human brain assessed by related pathological examination.We performed untargeted and targeted metabolomics 44 tissues. The differences hippocampus between group control (NC) were...
The whole world is suffering from the coronavirus disease 2019 (COVID-19) pandemic, induced by severe acute respiratory syndrome 2 (SARS-CoV-2) through angiotensin-converting enzyme (ACE2). Neurological manifestations in COVID-19 patients suggested invasion of SARS-CoV-2 into central nervous system. present study mapped expression level ACE2 12 brain regions immunohistochemistry and detected endothelial cells non-vascular cells. comparison among found that pons, visual cortex, amygdala...
Abstract The hippocampal–entorhinal system supports cognitive function and is selectively vulnerable to Alzheimer's disease (AD). Little known about global transcriptomic changes in the subfields during AD. Herein, large‐scale analysis performed five of postmortem brain tissues (262 unique samples). Differentially expressed genes are assessed across states, integrated genotype data from an AD genome‐wide association study. An integrative gene network bulk single‐nucleus RNA sequencing...
Abstract INTRODUCTION Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. METHODS Twelve decedents ADNC and 15 matched controls were selected from Brain Bank. The in median tunica basement membrane‐related extracellular matrix (ECM) contents quantified compared. Additionally, we explored related mechanisms agrin pericytes. RESULTS Venular collagenosis was...
Abstract BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) cognitive impairment in an autopsy‐confirmed cohort donated a human brain bank Beijing, China. METHODS A total 483 subjects were neuropathologically evaluated based on standardized protocols. Descriptive statistics ordinal logistic regression models used estimate correlation between CAA, AD, apolipoprotein E ( APOE ) genotyping, function proximal...
Amyloid beta (Aβ) plaques are one of the hallmarks Alzheimer's disease (AD). However, currently available anti-amyloid therapies fail to show effectiveness in treatment AD humans. It has been found that there different types Aβ plaque (diffuse and focal types) postmortem human brain. In this study, we aimed investigate correlations among AD-related neuropathological cognitive changes based on a brain bank China. The results indicated plaques, but not diffuse significantly increased with age...
Abstract Adult hippocampal neurogenesis (AHN), essential for the plasticity of structure and function, may be disrupted in Alzheimer‘s disease (AD). However, relationship between changes AHN AD‐related pathology humans remains uncertain. By utilizing advanced immunostaining techniques, we could identify multiple biomarkers representing different stages postmortem human tissue that exhibited various neuropathological changes. In this study, observed a significant presence neurogenic cells...
Dysfunctional Wnt signaling is associated with Alzheimer's disease (AD), and activation of the pathway inhibits AD development. Dickkopf 3 (Dkk3) a modulator physiologically expressed in brain. The role Dkk3 pathogenesis has not been evaluated. In present study, we determined that expression was significantly decreased brain tissue from patients transgenic mouse model APPswe/PS1dE9 (AD mice). Transgenic mice tissue-specific were generated or crossed to study effects on AD. mice, improved...
Genetic variations in the vacuolar protein sorting 10 (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from Vps10p sortilin at senile plaques (SPs) aged and AD human cerebrum. Sortilin changes were characterized postmortem brains with antibodies against extracellular intracellular C-terminal domains. The two exhibited identical labeling normal cerebrum, occurring somata dendrites cortical hippocampal neurons. antibody also marked...
Abstract Rho‐associated coiled‐coil kinase 1 (ROCK1) is proposed to be implicated in Aβ suppression; however, the role for ROCK1 amyloidogenic metabolism of amyloid precursor protein (APP) produce was unknown. In present study, we showed that activity and its APP binding were enhanced AD brain, resulting increased β‐secretase cleavage APP. Furthermore, firstly confirmed served as a substrate major phosphorylation site located at Ser655. The level Ser655 observed brain APP/PS1 mice patients...