A5103213747- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Biomedical Research and Pathophysiology
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Neurogenesis and neuroplasticity mechanisms
- Advanced Optical Imaging Technologies
- Amino Acid Enzymes and Metabolism
- GABA and Rice Research
- Silymarin and Mushroom Poisoning
- Peripheral Neuropathies and Disorders
- Optical measurement and interference techniques
- Uterine Myomas and Treatments
- Photodynamic Therapy Research Studies
- Complement system in diseases
- Gaze Tracking and Assistive Technology
- Pregnancy-related medical research
- Plant responses to water stress
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Peking Union Medical College Hospital
2019-2024
Washington University in St. Louis
2024
Tianjin University of Traditional Chinese Medicine
2024
Academy of Medical Sciences
2022
Beijing Institute of Technology
2022
Institute of Hematology & Blood Diseases Hospital
2021
Yangzhou University
2018
Abstract Background The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathological conditions. Multiple cytokines are released into the cerebrospinal fluid (CSF), potentially inducing activation of an cascade at remote segments through CSF flow. However, detailed alteration in neuropathic and its specific role remain obscure. Methods A chronic constriction injury infraorbital nerve (CCI-ION) model was constructed, pain-related...
As a classic innate immunity pathway, Toll-like receptor 4 (TLR4) signaling has been intensively investigated for its function of pathogen recognition. The is located not only on immune cells but also sensory neurons and spinal glia. Recent studies revealed the involvement neuronal TLR4 in different types pain. However, specific role pain symptom endometriosis (EM) remains obscure.The rat model was established by transplanting uterine horn tissue into gastrocnemius. Western blotting and/or...
Polyamines, including putrescine, spermidine, and spermine, play essential roles in a wide variety of prokaryotic eukaryotic organisms. Rice (Oryza sativa) contains four putative spermidine/spermine synthase (SPMS)-encoding genes (OsSPMS1, OsSPMS2, OsSPMS3, OsACAULIS5), but none have been functionally characterized. In this study, we used reverse genetic strategy to investigate the biological function OsSPMS1. We generated several homozygous RNA interference (RNAi) overexpression (OE) lines...
The whole world is suffering from the coronavirus disease 2019 (COVID-19) pandemic, induced by severe acute respiratory syndrome 2 (SARS-CoV-2) through angiotensin-converting enzyme (ACE2). Neurological manifestations in COVID-19 patients suggested invasion of SARS-CoV-2 into central nervous system. present study mapped expression level ACE2 12 brain regions immunohistochemistry and detected endothelial cells non-vascular cells. comparison among found that pons, visual cortex, amygdala...
Abstract Adult hippocampal neurogenesis (AHN), essential for the plasticity of structure and function, may be disrupted in Alzheimer‘s disease (AD). However, relationship between changes AHN AD‐related pathology humans remains uncertain. By utilizing advanced immunostaining techniques, we could identify multiple biomarkers representing different stages postmortem human tissue that exhibited various neuropathological changes. In this study, observed a significant presence neurogenic cells...
Neuropathic pain (NP) is the cardinal symptom of neural injury, and its underlying molecular mechanism needs further investigation. Complements, especially complement 3 (C3), are involved in pathophysiology many neurological disorders, while specific role C3 NP still obscure. In this study, we found that both receptor C3aR were upregulated spinal dorsal horn a rat chronic constriction injury (CCI) model. addition, was mainly detected astrocytes, expressed microglia neuron. Intrathecal...
Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that neuronal Fc-gamma-receptor type I (FcγRI) of dorsal root ganglion (DRG) mediates antigen-specific pain. However, FcγRI neuropathic remain be explored. Here, it found activation FcγRI-related signals primary neurons induces a rat model. This work first reveals sciatic nerve injury persistently activates signaling DRG, conditional...
Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies have demonstrated that functional Fcγ receptor I (FcγRI) expressed in dorsal root ganglion (DRG) neurons might contribute to rodent models of antigen-induced (AIA). This study was undertaken elucidate the roles nociceptive neuronal FcγRI-coupled signaling development AIA.RNA sequencing used investigate transcriptome profile changes DRG a rat model AIA. A primary sensory neuron-specific Fcgr1a...
Abstract Recent studies have noted the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in developing neuropathic pain, but underlying mechanisms are obscure. We found that PTEN was mainly expressed astrocytes rat spinal cord dramatically downregulated after chronic constriction injury (CCI). Intrathecal injection a inhibitor induced pain-related behaviors naive rats. By contrast, administration protector effectively mitigated CCI-induced pain. Adeno-associated...
Classical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process. However, treatments target mediators or immune cells are often unsatisfying in relieving the stubborn symptom. This additional mechanisms responsible for ACJ. In this study, we aim to determine role neuronal FcεRIa itch.Calcium imaging was applied observe effect IgE-immune complex trigeminal neurons. Genomic knockout mice and adeno-associated virus (AAV)...
Although previous reports have linked DNA damage with both transmissions across generations as well our own survival, it is unknown how to reverse the lesion. Based on data from a Randomized, Double-blind, Placebo Controlled Clinical Trial, this study aimed assess efficacy of folic acid supplementation (FAS) oxidative reversal. In randomized clinical trial (RCT), total 450 participants were enrolled and randomly assigned 3 groups receive (FA) 0.4 mg/day (low-FA), 0.8 (high-FA), or placebo...
To compare the prognosis of elderly patients with gastric and colorectal cancer treated different nutritional support methods.
Abstract Injury of peripheral nerves may quickly induce severe pain, but the mechanism remains obscure. We observed a rapid onset spontaneous pain and evoked hypersensitivity after acute transection L5 spinal nerve (SNT) in awake rats. The outburst was associated with development activities hyperexcitability nociceptive neurons adjacent uninjured L4 dorsal root ganglion (DRG), as revealed by both vivo electrophysiological recording high-throughput calcium imaging . Transection or intrathecal...
Neuropeptide Y (NPY) signaling plays an essential role in gating the pruritic afferent information spinal cord. Recent studies revealed that aging process down-regulated expression of NPY central nervous system. We propose lack may be involved certain types pruritus elderly population. This study was designed to investigate aging-induced itch using senile mouse model. The dorsal horn compared between young (2 months old) and aged (24 mice. Western blotting immunohistochemistry showed...
Sneezing and coughing are primary symptoms of many respiratory viral infections allergies. It is generally assumed that sneezing involve common sensory receptors molecular neurotransmission mechanism. Here we show the nasal mucosa innervated by several discrete populations neurons, but only one population (MrgprC11+MrgprA3-) mediates responses to a multitude irritants, allergens viruses. Although this also innervates trachea, it does not mediate as revealed our newly established cough model....
患者女性，36岁。临床主要表现为反复水肿、大量蛋白尿，既往肾组织穿刺活检病理诊断局灶增生性IgA肾病，予足量泼尼松（50 mg/d）联合免疫抑制剂（环磷酰胺累积剂量8.2 g）治疗，未达完全缓解。入院时24 h尿蛋白定量1.36 g，血白蛋白32 g/L，血肌酐75 μmol/L，总胆固醇6.55 mmol/L，IgG 3.56 g/L，抗核抗体H 1∶80。再次行肾组织穿刺活检病理示，轻度系膜增生性肾小球肾炎伴节段硬化，电镜示纤维样肾小球病，免疫组化示DNA-J热休克蛋白家族成员B9（DNAJB9）染色阳性，但蛋白质谱示DNAJB9阴性。诊断纤维性肾小球肾炎，继续小剂量环孢素A治疗（25 mg，每日2次），此后患者门诊规律随诊，尿蛋白逐渐减低，尿总蛋白肌酐比2 001 mg/g Cr，血肌酐86 μmol/L。纤维性肾小球肾炎是一种罕见的肾小球疾病，对治疗效果不佳的难治病例，应及时思考诊断与治疗的合理性，适当重复肾脏病理检查，为患者争取正确诊断、早期治疗的机会。.
Nervous system manifestations caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of great concern. Neurological symptoms and the neurological effects induced SARS-CoV-2, such as loss various sensory perceptions, indicate direct viral invasion into neurons. Therefore, it is very important to identify distribution angiotensin-converting enzyme (ACE2), receptor in human nervous system. However, autofluorescence from lipofuscin obviously impacted immunofluorescence...
<title>Abstract</title> <bold>Background: </bold>Astrocytes activation, which is polarized into neurotoxic A1, neuroprotective A2, and classical A-pan, thought to be involved in the transition from acute chronic post-thoracotomy pain. The C3aR receptor associated with astrocyte-neuron -microglia interactions necessary for A1 astrocytes polarization. This study aimed determine whether mediates pain by inducing expression rats thoracotomy model. <bold>Methods: </bold>Thoracotomy model was made...