A5017051467- Pain Mechanisms and Treatments
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Exercise and Physiological Responses
- Pain Management and Opioid Use
- Botulinum Toxin and Related Neurological Disorders
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Acupuncture Treatment Research Studies
- Pediatric Pain Management Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Smoking Behavior and Cessation
- Cancer-related molecular mechanisms research
- Bioactive Natural Diterpenoids Research
- Silymarin and Mushroom Poisoning
- Ion Channels and Receptors
- Musculoskeletal pain and rehabilitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Tianjin Medical University
2024-2025
Army Medical University
2025
Zhejiang University
2022-2024
Sir Run Run Shaw Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Peking Union Medical College Hospital
2020-2022
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
First Hospital of China Medical University
2018
Jinzhou Medical University
2018
Cervical cancer is one of the most common malignant tumors and leading cause cancer-related mortality in women. Persistent cervical infection by high-risk human papillomavirus (hrHPV) related to cancer. MicroRNAs could regulate autophagy caused viral infection. The aim present study was investigate regulation miR-155-5p In HPV+ lesion tissues, expression found be markedly decreased. Compared C33A cells (HPV−), significantly lower Siha HeLa (HPV+), which are both hrHPV positive. level higher...
Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients, but currently available treatments are often ineffective. Novel therapeutic targets for alleviation neuropathic urgently needed. Rhodojaponin VI, grayanotoxin from Rhododendron molle, showed remarkable antinociceptive efficacy in models pain, its biotargets mechanisms unknown. Given reversible action rhodojaponin VI narrow range over which structure can be modified, we perforwmed thermal...
China has approximately 300 million current smokers, and smoking cessation services are limited. This study aimed to assess the efficacy of a Cognitive Behavioral Theory-based intervention ('WeChat WeQuit') via most popular social media platform in China, WeChat.A parallel, single-blind, two-arm randomised controlled trial was conducted WeChat between March 19, 2020 November 16, 2022. Chinese-speaking adult smokers (n = 2000) willing quit within one month were recruited 1:1 ratio. The group...
Abstract Background The spinal inflammatory signal often spreads to distant segments, accompanied by widespread pain symptom under neuropathological conditions. Multiple cytokines are released into the cerebrospinal fluid (CSF), potentially inducing activation of an cascade at remote segments through CSF flow. However, detailed alteration in neuropathic and its specific role remain obscure. Methods A chronic constriction injury infraorbital nerve (CCI-ION) model was constructed, pain-related...
Acute lung injury (ALI) is a serious yet common complication in patients with traumatic brain (TBI), often associated poor prognosis. The development of TBI-induced ALI closely excessive oxidative stress and NLRP3 inflammasome activation. Fingolimod, an immunomodulatory agent, has been reported to attenuate inflammatory responses, restore blood-brain barrier integrity, reduce cerebral edema, mitigate neurological deficits. This study aimed investigate the mechanistic role activation evaluate...
Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that neuronal Fc-gamma-receptor type I (FcγRI) of dorsal root ganglion (DRG) mediates antigen-specific pain. However, FcγRI neuropathic remain be explored. Here, it found activation FcγRI-related signals primary neurons induces a rat model. This work first reveals sciatic nerve injury persistently activates signaling DRG, conditional...
Rheumatoid arthritis (RA) is often accompanied by joint pain and inflammation. Previous studies have demonstrated that functional Fcγ receptor I (FcγRI) expressed in dorsal root ganglion (DRG) neurons might contribute to rodent models of antigen-induced (AIA). This study was undertaken elucidate the roles nociceptive neuronal FcγRI-coupled signaling development AIA.RNA sequencing used investigate transcriptome profile changes DRG a rat model AIA. A primary sensory neuron-specific Fcgr1a...
Efficacy and safety are fundamental qualities to uphold improve when developing an extended-release carrier system for local anesthetics (LAs). This is especially true as diverse analgesics applied in multimodal analgesia regimens interactions between drugs may lead adverse events. Here we propose a new formulation of LA delivery: PLGA nanomembrane produced by electrospinning technique that allows improved better compatibility with combination regimen. In vitro release profile this exhibited...
Abstract Recent studies have noted the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in developing neuropathic pain, but underlying mechanisms are obscure. We found that PTEN was mainly expressed astrocytes rat spinal cord dramatically downregulated after chronic constriction injury (CCI). Intrathecal injection a inhibitor induced pain-related behaviors naive rats. By contrast, administration protector effectively mitigated CCI-induced pain. Adeno-associated...
Classical understanding of allergic conjunctivitis (ACJ) suggests that ocular itch results from a mast cell-dependent inflammatory process. However, treatments target mediators or immune cells are often unsatisfying in relieving the stubborn symptom. This additional mechanisms responsible for ACJ. In this study, we aim to determine role neuronal FcεRIa itch.Calcium imaging was applied observe effect IgE-immune complex trigeminal neurons. Genomic knockout mice and adeno-associated virus (AAV)...
Abstract Injury of peripheral nerves may quickly induce severe pain, but the mechanism remains obscure. We observed a rapid onset spontaneous pain and evoked hypersensitivity after acute transection L5 spinal nerve (SNT) in awake rats. The outburst was associated with development activities hyperexcitability nociceptive neurons adjacent uninjured L4 dorsal root ganglion (DRG), as revealed by both vivo electrophysiological recording high-throughput calcium imaging . Transection or intrathecal...
Pain on the body surface can accompany disorders in deep tissue or internal organs. However, anatomical and physiological mechanisms are obscure. Here, we provided direct evidence of axon bifurcation primary C-nociceptive neurons that innervate both skin a visceral organ. Double-labeled dorsal root ganglion (DRG) Evans blue extravasation were observed 3 types chemically-induced inflammation (colitis, urocystitis, acute gastritis) rat models. In colitis model, mechanical hypersensitivity...
Abstract Neuropathic pain is stubborn and associated with the peripheral nerve regeneration process. Nicotine has been found to reduce pain, but whether it involved in regulation of underlying mechanism are unknown. In this study, we examined mechanical allodynia thermal hyperalgesia together after nicotine exposure two rat neuropathic models. spinal ligation model, which anatomic can be easily observed, reduced measures as well expression marker growth-associated protein 43 (GAP43). tibial...
Pain management plays an essential role in medical care. Previous studies showed that pain is a dynamic process involving multiple mechanisms, which inspired the concept of multimodal analgesia. Therefore, drug delivery system loaded with single analgesic may be insufficient for control. In this study, implantable thermogel/electrospun fiber (Gel/Fiber) bupivacaine hydrochloride (BUP-HCl) and acetaminophen (APAP) was synthesized. composite, BUP-HCl preferentially released from hydrophilic...
Despite pituitary neuroendocrine tumor (PitNET) being extra-axial tumors without direct damage to brain tissue, patients with PitNET exhibit neuropsychological impairments. However, it remains unclear whether there are differences between and intra-axial that directly destroy the parenchyma. This prospective study aims clarify this distinction inform decision-making for intracranial of diverse origins.
本文报道一例腹型偏头痛患者的诊治过程。患者表现为周期性腹痛伴恶心、呕吐，完善电子胃镜、全消化道造影、腹盆CT等检查后未能发现明显器质性病变；追问病史：患者偶尔头痛，母亲患偏头痛20年，考虑腹型偏头痛可能，予诊断性治疗后患者症状发作明显减少。该类患者极易误诊为肠易激综合征或急腹症，分享本例诊治体会旨在提高内科医生对腹型偏头痛的认知，重视病史收集，在充分除外其他器质性疾病基础上应考虑该病，诊断性治疗是明确诊断的重要手段。.
Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized the chronic may result from sensitization of itch-signaling pathways but mechanisms remain obscure. In this study, we established mouse model compression dorsal root ganglion (CCD) and injected various pruritogenic algogenic agents intradermally to calf skin ipsilateral compressed (DRG). Compared naïve mice, significant increase itch-related behaviors was CCD mice after injection...
Abstract Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized the chronic may result from sensitization of itch-signaling pathways but mechanisms remain obscure. In this study, we established mouse model compression dorsal root ganglion (CCD) and injected various pruritogenic algogenic agents intradermally to calf skin ipsilateral compressed (DRG). Compared naïve mice, significant increase itch-related behaviors was CCD mice after injection...
Abstract Background : Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized the chronic may result from sensitization of itch-signaling pathways but mechanisms remain obscure. Methods: In this study, we established mouse model compression dorsal root ganglion (CCD) and injected various pruritogenic algogenic agents intradermally to calf skin ipsilateral compressed DRG. We additionally investigated if pruritogen-evoked activities (DRG) neurons...
Pain management plays an essential role in medical care. The understanding of pain has evolved that is a dynamic process involving changing pain-inducing mechanisms, which inspired the concept multimodal analgesia. Herein extended-drug delivery system loaded with single analgesic insufficient for control. A thermogel/electrospun fiber (Gel/Fiber) bupivacaine hydrochloride (BUP-HCl) and acetaminophen (APAP) respectively was synthesized. In composite, BUP-HCl released preferentially from...
Abstract Background Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that Fcγ receptor I (FcγRI) expressed neurons of dorsal root ganglion (DRG) may be involved chronic pain. Methods Chronic constriction injury (CCI) was used induce neuropathic rats. Primary neuron-specific Fcgr1 conditional knockout (CKO) rats were established by crossing carrying a loxP+/+ with Pirt CRE + line....