A5071643360- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Endometrial and Cervical Cancer Treatments
- Immunotherapy and Immune Responses
- Medical Research and Treatments
- Consumer Perception and Purchasing Behavior
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
Tianjin Medical University
2012-2024
Second Hospital of Tianjin Medical University
2012-2024
Cervical cancer is one of the most common malignant tumors and leading cause cancer-related mortality in women. Persistent cervical infection by high-risk human papillomavirus (hrHPV) related to cancer. MicroRNAs could regulate autophagy caused viral infection. The aim present study was investigate regulation miR-155-5p In HPV+ lesion tissues, expression found be markedly decreased. Compared C33A cells (HPV−), significantly lower Siha HeLa (HPV+), which are both hrHPV positive. level higher...
Abstract Ovarian cancer (OC) is the fifth‐leading cause of cancer‐related death in women with a pathogenesis involving activation regulatory T cells (Tregs). The T‐cell immunoglobulin and ITIM domain (TIGIT) well‐known immune checkpoint molecule that inhibits responses. However, role TIGIT OC not comprehensively understood. In this study, we revealed crucial functions development progression OC. ID8 were used to establish murine model. expression was increased mice, particularly CD4 + Tregs....
Immune checkpoint-based immunotherapy has shown limited efficacy in the treatment of ovarian cancer. In recent years, emergence immune checkpoint co-targeting therapies, led by combination targeting TIGIT and FAK, promise cancer treatment. Our preliminary research indicates that is predominantly expressed regulatory T cells during However, therapeutic impact based on remains to be elucidated. We utilized ID8 establish a mouse model Through flow cytometry co-culture methods, we validated...