A5101154477- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Sulfur Compounds in Biology
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Chromatography
- Antimicrobial Peptides and Activities
- Supercapacitor Materials and Fabrication
- Photoacoustic and Ultrasonic Imaging
- Supramolecular Self-Assembly in Materials
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
- Ferroptosis and cancer prognosis
- Synthesis and Characterization of Pyrroles
- Bacterial Infections and Vaccines
- Advancements in Battery Materials
- Environmental Changes in China
- Remote Sensing and Land Use
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- Pharmacological Effects of Natural Compounds
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
Army Medical University
2025
Beijing University of Chemical Technology
2017-2024
Ministry of Education of the People's Republic of China
2024
Northwest University
2024
Shihezi University
2024
Xiamen University
2022
Tan Kah Kee Innovation Laboratory
2022
Beijing Technology and Business University
2022
University of Wollongong
2022
Beijing Advanced Sciences and Innovation Center
2019-2020
Photodynamic therapy (PDT) and photothermal (PTT) are two kinds of treatment for tumors. Herein, a new aggregation-induced emission (AIE)gen (MeO-TPE-indo, MTi) is synthesized with D-π-A conjugated structure. MTi, which has an electron donor acceptor on tetraphenylethene (TPE) skeleton, can induce the effective generation reactive oxygen species (ROS) PDT. With guide indolium group, MTi target image mitochondrion selectively. In order to get good dispersion in water long-time retention...
Background: Pseudomonas aeruginosa represents a good model of antibiotic resistance. These organisms have an outer membrane with low level permeability to drugs that is often combined multidrug efflux pumps, enzymatic inactivation the drug, or alteration its molecular target. The acute and growing problem resistance bacteria conventional antibiotics made it imperative develop new liposome formulations for antibiotics, investigate fusion between bacterium. Methods: In this study, factors...
As an important reactive oxygen species, hypochlorous acid (HClO) is produced in various physiological processes. The abnormal rise of the HClO level associated with a large number inflammatory diseases. In this work, we develop simple, aqueous-soluble aggregration-induced emission (AIE) probe for sensing significant aggregation-induced fluorescence (>1000 times). Two probes, CH3O–TPE–Py+–N+ (COTN) and OH–TPE–Py+–N+ (HOTN) (TPE, tetraphenylethylene), are synthesized by cleavage Py+–N+ group;...
During an ERCP procedure for bile duct stones, the patient experienced basket impaction during operation. We successfully removed impacted reticular without complications, utilizing a temporary salvage device modified with lithotripter, thereby avoiding other future procedures such as ESWL or surgery.
Background: Pseudomonas aeruginosa represents a good model of antibiotic resistance. These organisms have an outer membrane with low level permeability to drugs that is often combined multidrug efflux pumps, enzymatic inactivation the drug, or alteration its molecular target. The acute and growing problem resistance conventional antibiotics made it imperative develop new liposome formulations overcome these mechanisms, investigate fusion between bacterium. Methods: rigidity, stability charge...
Accurate discrimination of cancerous cells is a good solution for early diagnosis tumors. The mitochondrion plays an important role in cells. Herein, the five aggregation-induced emission luminogens (AIEgens) with various double positive charges are synthesized to image mitochondria. Tetraphenylethylene (TPE) molecules modified by methoxy groups, conjugated donor–acceptor, and different achieve multicolor emission. AIEgens form PTx-Sa (positive mitochondria-target molecular sensor array)...
Abstract The construction of organelle‐targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type composite nanomaterial named as PTTPB developed. composed aggregation‐induced emission photosensitizer TTPB polydopamine nanomaterials. With the functional modification TTPB, can recognize sialic acid on cell membrane present mitochondrial targeted capabilities. intake in cancerous cells be increased by recognition process membrane. generate singlet...
Alzheimer's disease (AD) is a neurodegenerative disease, and β-amyloid (Aβ) believed to be causative factor in AD pathology. The abnormal deposition of Aβ responsible for progression AD. In order facilitate the imaging vivo, suitable probe molecules with near-infrared emission wavelength that can penetrate blood-brain barrier (BBB) were utilized. commercial fluorescent thioflavin-T (ThT) used image Aβ; however, because its short poor BBB penetration, ThT only vitro. With this research, based...
Shape memory alloy (SMA) wires are one of the widely used materials for soft artificial muscles. However, SMA muscles have two problems, including limited load holding ability due to their nature and slow response long cooling time. The main contributions this article developments a controllable magnetorheological fluid (MRF) exoskeleton fast-response elastomer-SMA muscle as effective approaches solve above-mentioned problems. MRF provides variable stiffness so that it can be flexible enough...
Abstract Semiconducting polymer nanoparticles (SPNs) have potential in biological applications. While some SPNs significant photothermal conversion efficiencies (PCEs) as and photoacoustic agents, other offer high fluorescence yields photoluminescent agents. However, the energy balance distribution inhibits their successful applications photoluminescence/photoacoustic (PL/PA) dual‐modality imaging. Additionally, ultrastability of vivo may cause damage to organisms. This work reports...
Hypochlorous acid (HOCl)/hypochlorite (OCl-), an important reactive oxygen species, plays a number of roles in various physiological processes. However, abnormal levels OCl- can cause many serious diseases, such as atherosclerosis, rheumatoid arthritis, cardiovascular disease, and cancer. The development efficient methods to monitor biological systems is therefore particular importance. Thus, we herein report novel isophorone-based fluorescent probe, i.e., DCOH-FR-OCl, for detection. This...
Abstract A newly 8‐aminoquioline based fluorescent probe ( NQA ) was designed and synthesized as a good turn‐on fluorescence sensor to reversibly detect Zn 2+ . The can in an aqueous solution with selectivity without interference from other metal ions (Cd particular). And the limit of detection calculated be 2.15×10 −9 M. efficiently monitor change concentration broad pH range 4.0 11.0. on coordination interaction. is biocompatibility used living cells similar cations, especially Cd
Microorganism are ubiquitous and intimately connected with human health disease management. The accurate fast identification of pathogenic microorganisms is especially important for diagnosing infections. Herein, three tetraphenylethylene derivatives (S-TDs: TBN, TPN, TPI) featuring different cationic groups, charge numbers, emission wavelengths, hydrophobicities were successfully synthesized. Benefiting from distinct cell wall binding properties, S-TDs collectively utilized to create a...
Artemether and lumefantrine (also known as benflumetol) are difficult to formulate for parenteral administration because of their low aqueous solubility. Cremophor EL an emulsion excipient has been shown cause serious side effects. This study reports a method preparation the therapeutic efficacies novel lipid (LE) delivery systems with artemether, lumefantrine, or artemether in combination administration. Their physical chemical stabilities were also evaluated. Furthermore, vivo antimalarial...
Background: Liposomes containing pH-sensitive polymers are promising candidates for the treatment of tumors and localized infection. This study aimed to identify parameters influencing extent contents release from poly(ethylacrylic acid) (PEAA) vesicles, focusing on effects polymer size, lipid composition, vesicle surface charge, temperature. Methods: Anchored PEAA was synthesized using with a molecular weight 8.4 kDa. vesicles were prepared by insertion lipid-anchored into preformed large...
Mitochondria play a key role in variety of physiological processes, and mitochondria-targeting drug delivery is helpful effective cancer therapy. Rhodamine123 (Rhod123) Doxorubicin (Dox) are not new chemical molecules, they both can inhibit the growth cancerous cells. Here, we combine these two "old" chemicals with polydopamine nanoparticles (PDA NPs) to strengthen antitumor effect aid near-infrared irradiation. PDA NPs carry tightly by hydrogen bonds π–π stacking besides bonds. The better...
A red mitochondria-targeted AIEgen with greater conjugate and more positive charges for visualizing H<sub>2</sub>S in cells tumours.