A5101759712- Adipose Tissue and Metabolism
- Bat Biology and Ecology Studies
- Muscle Physiology and Disorders
- Virus-based gene therapy research
- Pesticide Exposure and Toxicity
- Mitochondrial Function and Pathology
- Exercise and Physiological Responses
- Cancer Research and Treatments
- Meat and Animal Product Quality
- Sesquiterpenes and Asteraceae Studies
- Environmental Toxicology and Ecotoxicology
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Ultrasound and Hyperthermia Applications
- Analytical Chemistry and Chromatography
- RNA modifications and cancer
- Circular RNAs in diseases
- Cholesterol and Lipid Metabolism
- Insect and Pesticide Research
Northwest University
2016-2025
Ministry of Education of the People's Republic of China
2015-2024
Institute of Zoology
2009-2024
Chinese Academy of Sciences
2011-2024
Northeast Agricultural University
2021-2024
Xuzhou Medical College
2014-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
First Affiliated Hospital Zhejiang University
2001-2024
Southwest Jiaotong University
2024
Recent studies suggested the involvement of Akt/mammalian target rapamycin (mTOR) pathway in pathogenesis diabetic nephropathy. The effect mTOR blockade by nephropathy was investigated, but vivo study treatment course early diabetes is still insufficient. This designed to determine therapeutic effects on at an stage.Diabetes induced Sprague-Dawley rats with streptozotocin, and (1 mg/kg) administered daily gavage for 4 weeks. Renal structural changes some factors involved were tested....
<b><i>Background/Aims: </i></b>Tempol is a protective antioxidant against ischemic injury in many animal models. The molecular mechanisms are not well understood. Nuclear factor erythroid 2-related (Nrf2) master transcription during oxidative stress, which enhanced by activation of protein kinase C (PKC) pathway. Another factor, tubular epithelial apoptosis, mediated phosphoinositide 3-kinase (PI3K)/protein B (PKB, Akt) signaling pathway renal injury. We tested the...
CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, plays its function by catalyzing the hydrolysis of AMP into adenosine phosphate. In addition to this, accumulating data have shown that is key regulatory molecule involved cancer growth metastasis, but this cervical cells not been well studied. was overexpressed pcDNA-NT5E expression vector transfection Hela SiHa Cell's proliferation migration were evaluated MTT scratch healing assay. The specific antagonist...
Mammalian hibernators experience repeated hypoxic ischaemia and reperfusion during the torpor–arousal cycle. We investigated levels of oxidative stress, antioxidant capacity, underlying mechanism in heart, liver, brain kidney tissue as well plasma different periods hibernation Daurian ground squirrels ( Spermophilus dauricus ). Our data showed that hydrogen peroxide significantly increased heart late torpor (LT) compared with summer active (SA) state. The content malondialdehyde (MDA) was...
The phenotypic transformation from differentiated to dedifferentiated vascular smooth muscle cells (VSMCs) plays a crucial role in VSMC proliferation and remodeling many cardiovascular diseases including hypertension. Nesfatin-1, multifunctional adipocytokine, is critically involved the regulation of blood pressure. However, it still largely unexplored whether nesfatin-1 potential candidate switch Experiments were carried out Wistar-Kyoto rats (WKY), spontaneously hypertensive (SHR), human...
Quercetin and 2-Methoxyestradiol (2-ME) are promising anti-cancer substances. Our previous in vitro study showed that quercetin synergized with exhibiting increased antiproliferative proapoptotic activity both androgen-dependent LNCaP androgen-independent PC-3 human prostate cancer cell lines. In the present study, we determined whether their combination could inhibit xenograft tumor growth vivo explored underlying mechanism. Human cells were inoculated subcutaneously male BALB/c nude mice....
Salusin-β is abundantly expressed in many organs and tissues including heart, blood vessels, brain kidneys. Recent studies have identified salusin-β as a bioactive peptide that contributes to various diseases, such atherosclerosis, hypertension, diabetes metabolic syndrome. However, the role of pathogenesis acute kidney injury (AKI) largely unclear. In present study, we investigated roles cisplatin or lipopolysaccharide (LPS)-induced renal injury. Herein, found expression was upregulated...
In this study, the physicochemical properties and flavour profile of traditional dry sausages (T-SH, T-DXAL, T-HG, T-MDJ, T-HRB) collected from various wet markets were compared with those conventional (C-QL, C-ND, C-YSD, C-YC, C-HRL) food companies in northeast China. Traditional characterised by a low moisture content, water activity, high shear force after long fermentation time sausages. Electronic nose electronic tongue signals combined chemometrics methods applied for comprehensive...
Chlorpyrifos (CPF) and carbaryl (CAR) have been widely used in agricultural domestic settings. Previous studies demonstrated that CPF CAR are generally neurotoxic to mammals, whereas the toxicities of these pesticides other organs their potential interactive effects remain unclear. The purpose this study assessed alterations histopathology, biochemical parameters, metabolic profiles serum rats following treatment with alone or combination. No histopathological changes were observed liver...
Bromodomain-containing protein Brd4 is shown to persistently associate with chromosomes during mitosis for transmitting epigenetic memory across cell divisions. During interphase, also plays a key role in regulating the transcription of signal-inducible genes by recruiting positive elongation factor b (P-TEFb) promoters. How chromatin-bound transits into transcriptional regulation mode response stimulation, however, largely unknown. Here, analyzing dynamics ultraviolet or hexamethylene...