A5066796472- Protein Degradation and Inhibitors
- Alzheimer's disease research and treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- Genomics and Chromatin Dynamics
- Ophthalmology and Visual Impairment Studies
- Ubiquitin and proteasome pathways
- Electric Power System Optimization
- RNA and protein synthesis mechanisms
- Occupational Health and Safety Research
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Insect Resistance and Genetics
- HIV Research and Treatment
- Perovskite Materials and Applications
- HIV/AIDS drug development and treatment
- Vector-Borne Animal Diseases
- Conducting polymers and applications
- Integrated Energy Systems Optimization
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Melanoma and MAPK Pathways
- Drug Transport and Resistance Mechanisms
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
Harbin Institute of Technology
2022
Heilongjiang Institute of Technology
2022
Shenyang Jianzhu University
2020
Sun Yat-sen University
2015-2020
Xiamen University
2006-2016
Cornell University
2003
University of Arkansas for Medical Sciences
2000
Background Electronic medical records provide large-scale real-world clinical data for use in developing decision systems. However, sophisticated methodology and analytical skills are required to handle the datasets necessary optimisation of prediction accuracy. Myopia is a common cause vision loss. Current approaches control myopia progression effective but have significant side effects. Therefore, identifying those at greatest risk who should undergo targeted therapy great importance. The...
This study aims to explore the effect of implant apex design, osteotomy preparation, intraosseous depth and bone quality on immediate placement insertion torque establish a more sophisticated decision model with multi-factor analysis based machine learning for improving success rate placement. Six replicas each three systems different design were placed in polyurethane foam block densities(soft, medium hard) via two preparation protocols (normal undersized preparation) at depths (3 mm, 5 mm...
The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general mechanism for inducing promoter-proximal pausing Pol II. However, it remains largely unclear how paused released in response to stimulation. Here, we show that release cooperatively regulated by multiple P-TEFbs which are recruited bromodomain-containing protein Brd4 super elongation complex (SEC) via different recruitment mechanisms. Upon stimulation, recruits P-TEFb Spt5/DSIF a pathway consisting...
The proteolytic cleavage of Alzheimer beta-amyloid precursor protein (APP) and signaling receptor Notch is mediated by the PS/gamma-secretase complex, which consists presenilins, nicastrin, APH-1, PEN-2. Although four components are known to coordinately regulate each other at level, information regarding their transcription regulation scarce. Here we characterized 5'-flanking region human APH-1A gene identified a 271-bp fragment containing initiation site for promoter activity. Sequence...
Bromodomain-containing protein Brd4 is shown to persistently associate with chromosomes during mitosis for transmitting epigenetic memory across cell divisions. During interphase, also plays a key role in regulating the transcription of signal-inducible genes by recruiting positive elongation factor b (P-TEFb) promoters. How chromatin-bound transits into transcriptional regulation mode response stimulation, however, largely unknown. Here, analyzing dynamics ultraviolet or hexamethylene...
The Mediator is a multi-subunit complex that transduces regulatory information from transcription regulators to the RNA polymerase II apparatus. Growing evidence suggests plays roles in multiple stages of eukaryotic transcription, including elongation. However, detailed mechanism by which regulates elongation remains elusive. In this study, we demonstrate MED23 subunit controls basal level recruiting factor P-TEFb, via an interaction with its CDK9 subunit. mRNA Egr1, MED23-controlled model...
Faced with the challenge of population aging, a prolonged working life is increasingly important in today's society. Maintaining work ability employees one effective ways to cope challenges sustainability workforce presented by aging. Researchers have shown ongoing interest exploring determinants restricted ability. The aim this study was evaluate effects stress on among power supply workers Guangdong, China. A cross-sectional conducted during August 2014 September 2014. total 805 subjects...
Avian infectious bronchitis virus (IBV) causes a highly contagious and economically significant disease in chickens. Establishment of carrier state IBV infection the potential for persistent to undergo mutations recombination chicken tissues have important consequences management. Nevertheless, whether chickens can maintain absence reinfection from exogenous sources or presence antibody host modulate persistence remains unclear. Indeed, not genome genetic changes during vivo has been...
We retrospectively examined a large cohort of esophageal carcinoma patients who received early enteral nutrition (EEN) to clarify the validity EEN compared with total parenteral (TPN). Included were 665 consecutive histologically confirmed esophagus or esophagogastric junction; and all underwent esophagectomy. The divided into two groups: TPN (n = 262) 403). group consisted only intravenous support after operation. postoperative length hospital stay (PLOS), anastomotic leakage, mortality...
Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's beta-amyloid precursor protein (APP), signaling receptor Notch, and many other substrates, a multiprotein complex consisting at least four components: presenilin (PS), nicastrin, APH-1, PEN-2. Despite fact that PEN-2 known to mediate endoproteolytic full-length PS APH-1 nicastrin are required maintaining stability complex, detailed physiological function each component remain elusive. Unlike PS,...
Prader-Willi syndrome (PWS) is a genetic disease characterized by persistent hunger and hyperphagia. The lack of the Snord116 small nucleolar RNA cluster has been identified as major contributor to PWS symptoms. deletion (Snord116del) mouse model manifested subset symptoms including hyperphagia hyperghrelinemia. In this study, male Snord116del mice were tested for their acute chronic responses anorexic substances related ghrelin pathway. comparison with wild-type littermates, food intake...
Metal perovskite halides have led to the development of light-emitting diodes due their excellent optical and electrical properties. However, compared near-infrared, red, green diodes, blue-emitting lag far behind in poor stability low quantum efficiency. In this review, latest advances blue are described, including three-dimensional perovskites, two-dimensional/quasi-two-dimensional nanocrystals. section, choices halide composition, electron transport layer hole enable tunable light...
Wearable pressure sensors have great potential for applications in electronic skin, patient rehabilitation, and touch interfaces. In this paper, state-of-the-art achievements on typical low-dimensional nanostructured wearable hybrid are reviewed. the two-dimensional-nanostructure section, two-dimensional transition metal carbides (MXenes) a large specific area excellent hydrophilicity, which ensures high sensitivity detection. Graphene can also represent sensing materials due to its...
Elevated creatine kinase (CK) in the circulation was generally regarded to be a passive release from muscle damage. We utilized proteomic methodologies characterize amphioxus humoral fluid APPs response caudal trauma, and found several spots of CK alterations with up-regulation pI shift. Its amount enzyme activity showed dynamic pattern APP accompanied reduction muscle, whereas there no significant difference other tissues between different time points sample collection following trauma. In...
The majority of rare diseases are complex caused by a combination multiple morbigenous factors. However, uncovering the etiology and pathogenesis is difficult due to limited clinical resources conventional statistical methods. This study aims investigate interrelationship effectiveness potential factors pediatric cataract, for exploration data mining strategy in scenarios diseases.We established pilot disease specialized care center systematically record all information entire treatment...
Prostratin has been proposed as a promising reagent for eradicating the latent HIV-1 provirus by inducing transcription activation. The molecular mechanism of this activation, however, is far from clear. Here, we show that protein kinase D3 (PKD3) essential prostratin-induced activation provirus. First, silencing PKD3, but not other members PKD family, blocked HIV-1. Second, overexpressing constitutively active form wild-type or kinase-dead augmented expression Consistent with observation,...
The deposition of amyloid-beta is a pathological hallmark Alzheimer's disease. Amyloid-beta derived from amyloid precursor protein through sequential proteolytic cleavages by β-secretase (beta-site protein-cleaving enzyme 1) and γ-secretase. To further elucidate the roles beta-site 1 in development disease, yeast two-hybrid system was used to screen human embryonic brain cDNA library for proteins directly interacting with intracellular domain 1. A potential 1-interacting identified positive...
Abstract This paper proposes a bilevel optimal scheduling model considering the flexibility and peak shaving benefits of gas-steam combined cycle units, which realizes “thermoelectric decoupling” unit by configuring electric boilers, adds benefit to upper maximize profit unit. Among them, is bidding benefits, lower power market-clearing maximization social welfare. The bilayer transformed into mixed-integer linear programming problem through KKT conditions other solution methods....