A5028335544- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Renal and related cancers
- Plant Stress Responses and Tolerance
- Fetal and Pediatric Neurological Disorders
- Plant Parasitism and Resistance
- Congenital heart defects research
- Genomics, phytochemicals, and oxidative stress
- Landslides and related hazards
- Single-cell and spatial transcriptomics
- Wastewater Treatment and Nitrogen Removal
- RNA Research and Splicing
- Pediatric Urology and Nephrology Studies
- Coronary Interventions and Diagnostics
- Tumors and Oncological Cases
- Ovarian cancer diagnosis and treatment
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Antiplatelet Therapy and Cardiovascular Diseases
- Agricultural Science and Fertilization
- Williams Syndrome Research
- Plant pathogens and resistance mechanisms
- Chromium effects and bioremediation
- Plant Gene Expression Analysis
- Nitrogen and Sulfur Effects on Brassica
Tianjin Chest Hospital
2024-2025
Tianjin University
2025
Guangzhou Medical University
2018-2024
Chongqing University
2024
Central South University
2020-2023
Gansu Agricultural University
2020-2022
Panzhihua Academy of Agriculture and Forestry Sciences
2021
Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution
2020
Guangzhou Women and Children Medical Center
2018
Abstract Background Exome sequencing (ES) is becoming more widely available in prenatal diagnosis. However, data on its clinical utility and integration into management remain limited practice. Herein, we report our experience implementing ES (pES) a large cohort of fetuses with anomalies detected by ultrasonography using hospital-based in-house multidisciplinary team (MDT) facilitated three-step genotype-driven followed phenotype-driven analysis framework. Methods We performed pES 1618...
Background: Severe in-stent restenosis (ISR) following the implantation of drug-eluting stent (DES) can lead to recurrent angina pectoris or even acute myocardial infarction, thereby necessitating target lesion revascularization (TLR). Prior studies have confirmed correlation between monocyte high-density lipoprotein cholesterol ratio (MHR) and ISR after DES implantation. The potential MHR predict TLR remains an area ongoing research may significant clinical implications. Methods: A...
Background: Microcephaly is common in patients with neuropsychiatric problems, and it usually closely related to genetic causes. However, studies on chromosomal abnormalities single-gene disorders associated fetal microcephaly are limited. Objective: We investigated the cytogenetic monogenic risks of evaluated their pregnancy outcomes. Methods: performed a clinical evaluation, high-resolution microarray analysis (CMA), trio exome sequencing (ES) 224 fetuses prenatal followed outcome...
There are a few literature reports of prenatal ultrasound manifestations Williams-Beuren syndrome. We aimed to explore the diagnosis syndrome by and chromosomal microarray analysis describe performance this syndrome.In retrospective study, we reported eight cases diagnosed at our diagnostic center from 2016 2021. systematically reviewed clinical data these cases, including indications for invasive testing, sonographic findings, QF-PCR results, pregnancy outcomes.In common features were...
Abstract Objective To assess the value of chromosome microarray analysis (CMA) and whole exome sequencing (WES) in fetuses with cerebellar vermis defects (CVD). Methods From 2013 to 2019, we performed CMA on 43 CVD, who were divided into hypoplasia (CVH) group Dandy‐Walker malformation (DWM) according morphological subtypes. Subsequently, WES was 19 normal results identify diagnostic genetic variants (DGVs). Results Chromosome aneuploidies clinically significant copy number identified 23.3%...
Soil water repellency (SWR) is a physical phenomenon whereby cannot penetrate or has difficulty penetrating the soil surface. There are many factors involved in its occurrence, but main controlling emergence loess remain unclear. In this work, we have studied numerous physicochemical and biological functioning different dominant vegetations (Pinus tabulaeformis Carr., Robinia pseudoacacia L., Hippophae rhamnoides L.) hilly region by gas chromatography-mass spectrometry (GC-MS)...
Abstract To summarize the results of prenatal diagnoses and pregnancy outcomes fetuses with thickened nuchal fold (TNF) in second trimester. From 2009 to 2016, we studied 72 pregnant women fetal (NF) measurements over 5 mm at 14 19 + 6 weeks or 20 28 gestation who received diagnosis. Karyotypes were first used detect common chromosomal diseases, then chromosome microarray analysis (CMA) was performed if karyotypes normal. Prognoses followed up by documentation hospital telephone. In total,...
SHOX haploinsufficiency have been commonly found in isolated short stature (ISS) and Léri-Weill dyschondrosteosis (LWD) patients. However, few publications described the genetic analysis clinical characteristics of fetuses with haploinsufficiency.Chromosomal microarray (CMA) were applied 14,051 sequentially whole exome sequence (WES) 1340 who underwent prenatal diagnosis during 2016-2021. The summary molecular genetics, sonographic characteristics, follow-up results performed without other...
Abstract Background The molecular mechanism of fetal cystic hygroma (CH) is still unclear, and no study has previously reported the transcriptome changes single cells in CH. In this study, single-cell sequencing (scRNA-seq) was used to investigate characteristics cell subsets lesion tissues CH patients. Methods Lymphoid tissue collected from patients control donors for scRNA-seq analysis. Differentially expressed gene enrichment major subpopulations as well cell-cell communication were...
As common backfill materials, soil-rock mixtures (SRMs) are extensively employed in the construction of high-fill roadbed slopes. The stability slopes is determined by mechanical properties SRM, which complex and difficult to accurately measure. To assess safety constructed with SRMs, it crucial develop a more precise experimental approach for investigating shear SRMs. discrete element method (DEM) powerful tool analyzing heterogeneous geomaterials. In this paper, reverse model rock blocks...
17q12 copy number variants (CNVs) have variable presentations and incomplete penetrance, challenging prenatal counseling management. This study aims to investigate the intrauterine phenotype.
Several studies have shown that the monocyte count to high-density lipoprotein cholesterol ratio (MHR) serves as a predictive marker for in-stent restenosis (ISR) of bare-metal stents (BMSs). However, ability MHR predict ISR in patients with drug-eluting (DESs) remains uncertain. This study aimed investigate value unstable angina pectoris who undergone primary DES implantation. A total 474 consecutive underwent successful DES-based percutaneous coronary intervention (PCI) from 01-12-2014...
Background: Ovarian cancer is a gynecological neoplastic disease with high mortality rate. Its early detection difficult because of the lack specific clinical symptoms. This study aimed to identify key genes and prognosis factors associated ovarian provide new information thus better understanding cancer.Methods: Microarray data from Gene Expression Omnibus (GEO) database (accession number GSE38551) were used for analysis. Differentially expressed (DEGs) screened, functional enrichment...