A5056293782- Gut microbiota and health
- Probiotics and Fermented Foods
- Genomics and Phylogenetic Studies
- Nanoplatforms for cancer theranostics
- Catalytic Cross-Coupling Reactions
- Animal Nutrition and Physiology
- Clostridium difficile and Clostridium perfringens research
- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Cell Adhesion Molecules Research
- Catalytic C–H Functionalization Methods
- Peroxisome Proliferator-Activated Receptors
- Organoboron and organosilicon chemistry
- Advanced Nanomaterials in Catalysis
- Luminescence Properties of Advanced Materials
- Cerebrovascular and genetic disorders
- Adipose Tissue and Metabolism
- Animal Diversity and Health Studies
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
- Microbial Metabolites in Food Biotechnology
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Selenium in Biological Systems
Shanghai Jiao Tong University
2016-2025
Tianjin Chest Hospital
2024-2025
Tianjin University
2025
Guangxi University
2024
Peking University
2012-2024
Inner Mongolia University
2021-2024
Peking University Cancer Hospital
2023-2024
Southwest Jiaotong University
2024
Shanghai First People's Hospital
2024
Central South University
2023-2024
Novel theranostics based on photosensitizer-conjugated carbon dots is reported. The prepared C-dots–Ce6 has good stability and high water dispersibility solubility, non-cytotoxicity, biocompatibility, enhanced photosensitizer fluorescence detection remarkable photodynamic efficacy upon irradiation. conjugate a candidate with excellent imaging tumor-homing ability for NIR monitored PDT treatment. Detailed facts of importance to specialist readers are published as "Supporting Information"....
Metagenome of gut microbes has been implicated in metabolism, immunity, and health maintenance its host. However, most previous studies, the microbiota was sampled from feces instead gastrointestinal (GI) tract. In this study, we compared microbial populations at four different developmental stages contents intestinal segments maturity to examine dynamic shift pigs investigated whether adult porcine fecal samples could be used represent GI Analysis results revealed that ratio Firmicutes...
Host genotype and gender are among the factors that influence composition of gut microbiota. We studied population structure microbiota in two lines chickens maintained under same husbandry dietary regimes. The lines, which originated from a common founder population, had undergone 54 generations selection for high (HW) or low (LW) 56-day body weight now differ by more than 10-fold at age. Of 190 microbiome species, 68 were affected (line), interactions. Fifteen species belong to...
Abstract A novel OA/ionic liquid two‐phase system combining the merits of thermal decomposition method, IL‐based strategy, and approach is introduced to synthesize high‐quality lanthanide‐doped NaGdF 4 upconversion nanocrystals with different crystal‐phases in OA‐phase IL‐phase through a one‐step controllable reaction. Oil‐dispersible cubic‐phase :Yb, Er (Ho, Tm) ultra‐small size (∼5 nm) monodispersity are obtained OA phase via an More importantly, water‐soluble hexagonal‐phase same simply...
In mammals, the microbiota can be transmitted from placenta, uterus, and vagina of mother to infant. Unlike development avian embryo is a process isolated thus in gut microbial developmental remains elusive. To explore establishment inheritance microbiome embryo, we used chicken as model organism investigate composition embryos, chicks maternal hens. We observed: (1) 28 phyla 162 genera microbes embryos where dominated genus was Halomonas (79%). (2) 65 were core all stages with 42% 62% found...
Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events. Although antiphospholipid antibodies have been shown to promote thrombosis in mice, the role neutrophils has not explicitly studied. The aim this study was characterize context new model antibody-mediated venous thrombosis.Mice were administered fractions IgG obtained from patients with APS. At same time, blood flow through inferior vena cava reduced by induction stenosis. Resulting thrombi characterized for...
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with syndrome (APS). Surface adenosine receptors trigger cyclic AMP (cAMP) formation neutrophils, and this has been proposed to regulate NETosis some contexts. Here we report that selective agonism the A2A receptor (CGS21680) suppresses aPL Ab-mediated protein kinase A-dependent fashion. CGS21680 also reduces thrombosis inferior vena...
Background and Purpose— Advanced age is associated with a decrease in brain plasticity compared the young adult. Sildenafil, phosphodiesterase type 5 (PDE5) inhibitor promotes improves functional outcome after stroke animal. Here, we test hypothesis that sildenafil provides restorative therapeutic benefit to aged Methods— Male Wistar rats (aged, 18-month old; young, 3-month old) were subjected embolic stroke. Saline or was administered daily at dose of 2 mg/kg orally 10 subcutaneously for 7...
Bactrian camels serve as an important means of transportation in the cold desert regions China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both wild domestic bactrian camel. We estimate camel to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that shared common ancestors with other even-toed ungulates about 55–60 million years ago. Rapidly evolving genes lineage are significantly enriched metabolic pathways, these changes may...
A metal-free borylation process based on Sandmeyer-type transformation using arylamines derivatives as the substrates has been developed. Through optimization of reaction conditions, this novel conversion can be successfully applied to a wide range aromatic amines, affording products in moderate good yields. Various functionalized arylboronates, which are difficult access by other methods, easily obtained with transformation. Moreover, followed Suzuki-Miyaura cross-coupling without...
The homeostasis of host-microbiota interactions is great importance to host health. Previous studies demonstrated that disruption autophagy was linked inflammatory bowel disease. However, the interaction mechanism gut microbiota regulated by obscure. In an intestinal epithelium-specific autophagy-related 5 ( Atg5 ) knockout mouse model, we observed a significant alteration and decreased diversity in -deficient mice compared with wild-type mice. Although numbers some organisms (e.g.,...
Antiphospholipid antibodies, present in one-third of lupus patients, increase the risk thrombosis. We recently reported a key role for neutrophils - neutrophil extracellular traps (NETs), particular thrombotic events that define antiphospholipid syndrome (APS). To further elucidate APS, we performed comprehensive transcriptome analysis isolated from patients with primary APS. Moreover, APS-associated venous thrombosis was modeled by treating mice IgG prepared APS followed partial restriction...
Background Systemic Immune-inflammation Index (SII) and body composition parameters are easily assessed, can predict overall survival (OS) in various cancers, allowing early intervention. This study aimed to assess the correlation between CT-derived SII OS patients with advanced gastric cancer receiving dual programmed death-1 (PD-1) human epidermal growth factor receptor 2 (HER2) blockade. Materials methods retrospective enrolled treated PD-1 HER2 blockade from March 2019 June 2022. We...
Abstract Tumor metastasis and relapse mainly results in therapy failure becomes a big challenge oncology. Immunogenic cell death (ICD) of tumors mediated immunotherapy (IT) is attracting widely for solving that problem although achieving sufficient ICD strong immune response challenging nanoparticles‐based cancer IT. Herein, multifunctional polypeptide coordinate nanocomposite possesses near infrared photothermia (PT) responsive releases nitric oxide (NO) iron ions constructed, which...
The sole use of single modality data often fails to capture the complex heterogeneity among patients, including variability in resistance anti-HER2 therapy and outcomes combined treatment regimens, for HER2-positive gastric cancer (GC). This deficit has not been fully considered many studies. Furthermore, application artificial intelligence predicting response, particularly diseases such as GC, is still its infancy. Therefore, this study aimed a comprehensive analytic approach accurately...
mineralocorticoid receptor (MR) antagonists have protective effects in rodent models of ischemic stroke, but the cell type-specific actions these drugs are unknown. In present study, we examined contribution myeloid MR during focal cerebral ischemia using myeloid-specific knockout mice.myeloid-specific mice were subjected to transient (90 minutes) middle artery occlusion followed by 24 hours reperfusion (n=5 7 per group). Ischemic infarcts identified hematoxylin and eosin staining quantified...
Development of multimodal contrast agents for in vivo simultaneous multimodality imaging is an emerging interdiscipline that paving the avenue toward goal personalized medicine. Herein, folic acid-conjugated silica-modified LaF3:Yb,Tm upconversion nanoparticles (UCNPs@SiO2-FA) with high La content a single particle were strategically designed and prepared simultaneously targeting dual-modality luminescence (UCL) X-ray computed tomography (CT). LaF3 UCNPs synthesized by novel oleic acid...
Karyotypic diversification is more prominent in Equus species than other mammals. Here, using next generation sequencing technology, we generated and de novo assembled quality genomes sequences for a male wild horse (Przewalski's horse) domestic (Mongolian horse), with about 93-fold 91-fold coverage, respectively. Portion of Y chromosome from assemblies (3 M bp) Mongolian (2 were also sequenced assembled. We confirmed Robertsonian translocation event through the horse's chromosomes 23 24,...