A5100458058- Nanoplatforms for cancer theranostics
- Catalytic Processes in Materials Science
- Nanocluster Synthesis and Applications
- Catalysis and Oxidation Reactions
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- X-ray Diffraction in Crystallography
- Luminescence Properties of Advanced Materials
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Catalysis and Hydrodesulfurization Studies
- Photodynamic Therapy Research Studies
- Bone Tissue Engineering Materials
- Quantum Dots Synthesis And Properties
- Luminescence and Fluorescent Materials
- Photoacoustic and Ultrasonic Imaging
- Graphene and Nanomaterials Applications
- Industrial Gas Emission Control
- Advanced Optical Network Technologies
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Nanomaterials for catalytic reactions
- Epigenetics and DNA Methylation
Northeast Forestry University
2012-2025
Nanjing Agricultural University
2023-2025
Nanjing University of Chinese Medicine
2023-2025
Shanghai Jiao Tong University
2014-2024
Shenyang Normal University
2021-2024
Chinese Academy of Sciences
2012-2024
University of Science and Technology of China
2024
Shandong Normal University
2024
Peking University
2024
Peking University Third Hospital
2024
Novel theranostics based on photosensitizer-conjugated carbon dots is reported. The prepared C-dots–Ce6 has good stability and high water dispersibility solubility, non-cytotoxicity, biocompatibility, enhanced photosensitizer fluorescence detection remarkable photodynamic efficacy upon irradiation. conjugate a candidate with excellent imaging tumor-homing ability for NIR monitored PDT treatment. Detailed facts of importance to specialist readers are published as "Supporting Information"....
Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer well non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cells followed irradiation.The use nanomaterials carriers PSs is a very approach to improve development PDT in clinical medicine.In this study, novel folic acid-conjugated graphene oxide (GO) was strategically designed prepared targeting drug delivery system achieve higher specificity.The second generation...
Fourteen volatile organic compound (VOC) biomarkers in the breath have been identified to distinguish early gastric cancer (EGC) and advanced (AGC) patients from healthy persons by gas chromatography–mass spectrometry coupled with solid phase microextraction (SPME). Then, a analysis approach based on surface-enhanced Raman scattering (SERS) sensor was developed detect these biomarkers. Utilizing hydrazine vapor adsorbed graphene oxide (GO) film, clean SERS is facilely prepared situ formation...
A red-emitting BODIPY-based fluorescent-resonance-energy-transfer (FRET) molecular probe 1 for selective detection of cysteine and homocysteine was designed. The fluorescence OFF–ON switch is triggered by cleavage the 2,4-dinitrobenzensulfonyl (DNBS) unit from fluorophore thiols. FRET energy donor (λabs = 498 nm, λem 511 nm) a parent BODIPY moiety acceptor based on 4-hydroxylstyryl 568 586 nm). unique C–C linker between established using Suzuki cross-coupling reaction. polyether chain also...
Abstract A novel OA/ionic liquid two‐phase system combining the merits of thermal decomposition method, IL‐based strategy, and approach is introduced to synthesize high‐quality lanthanide‐doped NaGdF 4 upconversion nanocrystals with different crystal‐phases in OA‐phase IL‐phase through a one‐step controllable reaction. Oil‐dispersible cubic‐phase :Yb, Er (Ho, Tm) ultra‐small size (∼5 nm) monodispersity are obtained OA phase via an More importantly, water‐soluble hexagonal‐phase same simply...
Gold nanoclusters (GNCs) attract increasing attention due to their potential applications in sensing, catalysis, optoelectronics, and biomedicine. Herein, the formation of highly fluorescent glutathione (GSH)‐capped GNCs is achieved through delicate control reduction kinetics thermodynamic selection Au(I)–SG complexes. Furthermore, GNCs‐based nanoprobes are developed by covalent coupling folic acid (FA) PEG (polyethylene glycol) on surface directly, followed trapping photosensitizer (chlorin...
How to improve effective accumulation and intratumoral distribution of plasmonic gold nanoparticles has become a great challenge for photothermal therapy tumors. Herein, we reported nanoplatform with therapeutic effects by fabricating Au nanorods@SiO2@CXCR4 loading the prepared into human induced pluripotent stem cells(AuNRs-iPS). In virtue prominent optical properties remarkable tumor target migration ability iPS cells, nanorods delivery mediated cells via AuNRs-iPS was found have prolonged...
Abstract The onset of implant‐associated infection (IAI) triggers a cascade immune responses, which are initially dominated by neutrophils. Bacterial aggregate formation and hypoxic microenvironment, occur shortly after implantation, may be two major risk factors that impair neutrophil function lead to IAI. Here, the implant surface with phytic acid–Zn 2+ coordinated TiO 2 nanopillar arrays (PA–Zn@TiNPs) oxygen self‐supporting CaO nanoparticles, named as CPZTs, is mechanochemically...
Because of their special physicochemical properties, pore-structured metal oxide catalysts are widely used in environmental catalysis, energy chemicals, fuel cells, medicine, and other related fields. In recent years, these oxides have also been increasingly studied the catalytic purification diesel engine exhaust gases. this paper, research progresses preparation methods porous application were reviewed. The advantages disadvantages different for synthesis elaborated, as well mechanism...
Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release.However, few report is associated with the ROS responsive release.Herein, a thioketal linker-based (camptothecin conjugated linker, abbreviated TL-CPT) was prepared linker could be cleaved by ROS(reactive oxygen species).To achieve cancer simultaneous optical imaging, photodynamic therapy chemotherapy, photosensitizer Chlorin...
Developing safe and effective nanoprobes for targeted imaging selective therapy of gastric cancer stem cells (GCSCs) has become one the most promising anticancer strategies.Herein, gold nanostars-based PEGylated multifunctional were prepared with conjugated CD44v6 monoclonal antibodies (CD44v6-GNS) as targeting ligands.It was observed that had high affinity towards GCSC spheroid colonies destroyed them completely a low power density upon near-infrared (NIR) laser treatment (790 nm, 1.5 W/cm...
Fluorescent carbon dots (Cdots) have attracted increasing attention due to their potential applications in sensing, catalysis, and biomedicine. Currently, intensive research has been concentrated on the synthesis imaging-guided therapy of these benign photoluminescent materials. Meanwhile, Cdots explored as nonviral vector for nucleic acid or drug delivery by chemical modification purpose. We developed a microwave assisted one-step with citric source tryptophan (Trp) both nitrogen...
Gastric cancer (GC) is the second most common in China and leading cause of cancer-related death world.Identifying circulating biomarkers helpful to improve theranostics gastric cancer.Herein, we are for first time report miR-16-5p miR-19b-3p were identified be novel potential plasma detect cancer.Differentially expressed miRNAs initially screened out by genome-wide miRNA profiling microarrays between 16 samples 18 matched normal controls, then quantified validated quantitative reverse...
Mitochondria in cancer cells maintain a more negative membrane potential than normal cells.Mitochondria are the primary source of cellular reactive oxygen species (ROS), which necessary for photodynamic therapy.Thus, strategy targeting mitochondria can maximize therapeutic efficiency cancer.Here we report, first time, synthesis new mitochondria-targeting drug delivery system, ZnPc/CPT-TPPNPs.To synthesize this novel compound, polyethylene glycol was functionalized with thioketal...
The development of visual tumor theranostic nanoparticles has become a great challenge. In this study, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was conjugated to acid-sensitive cis-aconitic anhydride-modified doxorubicin (CAD) obtain pH-sensitive anti-tumor prodrug (TCAD NPs) via self-assembling. Subsequently, the photosensitizer chlorin e6 (Ce6) loaded into resulting prepare novel near-infrared fluorescence imaging and chemo-photodynamic combination therapy system (TCAD@Ce6...
Rationale:Recently, there is one-fifth of human deaths caused by cancer, leading to cancer treatment remains a hard nut crack in the medical field.Therefore, as an emerging diagnostic technology, mesoporous nanomaterials-based drug delivery systems integrated diagnosis and therapy have aroused tremendous interest owing visually targeting effect superior efficacy compared with traditional treatment.Methods: In this work, we successfully synthesized carbon-gold hybrid nanozyme nanoprobes,...