A5101908552- Nanoplatforms for cancer theranostics
- Advanced Fiber Optic Sensors
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Photonic and Optical Devices
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Calibration and Measurement Techniques
- Extracellular vesicles in disease
- Thermography and Photoacoustic Techniques
- Combustion and Detonation Processes
- Gold and Silver Nanoparticles Synthesis and Applications
- Non-Destructive Testing Techniques
- Nanocluster Synthesis and Applications
- Optical Systems and Laser Technology
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Immunotherapy and Immune Responses
- Advanced Fiber Laser Technologies
- Biodiesel Production and Applications
- Surface Roughness and Optical Measurements
- Photonic Crystal and Fiber Optics
- Gallbladder and Bile Duct Disorders
- Welding Techniques and Residual Stresses
- Radiative Heat Transfer Studies
Shanghai Jiao Tong University
2016-2025
National Engineering Research Center for Nanotechnology
2020-2025
Henan Normal University
2018-2025
Guangdong Medical College
2025
Hangzhou Special Equipment Inspection and Research Institute
2010-2024
Harbin Engineering University
2005-2024
Nanjing University of Aeronautics and Astronautics
2024
Nanjing Tech University
2021-2022
China National Petroleum Corporation (China)
2022
Shenzhen University
2021
Gold nanoclusters (GNCs) attract increasing attention due to their potential applications in sensing, catalysis, optoelectronics, and biomedicine. Herein, the formation of highly fluorescent glutathione (GSH)‐capped GNCs is achieved through delicate control reduction kinetics thermodynamic selection Au(I)–SG complexes. Furthermore, GNCs‐based nanoprobes are developed by covalent coupling folic acid (FA) PEG (polyethylene glycol) on surface directly, followed trapping photosensitizer (chlorin...
How to improve effective accumulation and intratumoral distribution of plasmonic gold nanoparticles has become a great challenge for photothermal therapy tumors. Herein, we reported nanoplatform with therapeutic effects by fabricating Au nanorods@SiO2@CXCR4 loading the prepared into human induced pluripotent stem cells(AuNRs-iPS). In virtue prominent optical properties remarkable tumor target migration ability iPS cells, nanorods delivery mediated cells via AuNRs-iPS was found have prolonged...
The low efficiency of photodynamic therapy (PDT) is caused by tumor hypoxia and the adaptive immune resistance/evasion cells, while currently emerging checkpoint restores intrinsic capacities but can't directly attack cells. Methods: Herein we report an integrated nanoplatform that combines PDT with immunotherapy to enhance therapeutic effects simultaneously inhibit cells resistance/evasion. To achieve this, fabricated Mn@CaCO3/ICG nanoparticles loaded them PD-L1-targeting siRNA. Results:...
Mitochondria in cancer cells maintain a more negative membrane potential than normal cells.Mitochondria are the primary source of cellular reactive oxygen species (ROS), which necessary for photodynamic therapy.Thus, strategy targeting mitochondria can maximize therapeutic efficiency cancer.Here we report, first time, synthesis new mitochondria-targeting drug delivery system, ZnPc/CPT-TPPNPs.To synthesize this novel compound, polyethylene glycol was functionalized with thioketal...
Abstract Gastric cancer is the second leading cause of cancer-related death worldwide. RNA nanotechnology has recently emerged as an important field due to recent finding its high thermodynamic stability, favorable and distinctive in vivo attributes. Here we reported use thermostable three-way junction (3WJ) bacteriophage phi29 motor pRNA escort folic acid, a fluorescent image marker BRCAA1 siRNA for targeting, imaging, delivery, gene silencing regression gastric animal models. In vitro...
Different stimulus including pH, light and temperature have been used for controlled drug release to prevent inactivation minimize side-effects.Herein a novel nano-platform (GNS@CaCO3/ICG) consisting of calcium carbonate-encapsulated gold nanostars loaded with ICG was established couple the photothermal properties (GNSs) photodynamic indocyanine green (ICG) in photodynamic/photothermal combination therapy (PDT/PTT).In this study, carbonate worked not only keeper entrap on surface GNSs form...
Abstract Background Gene and chemical therapy has become one of the rising stars in field molecular medicine during last two decades. However, there are still numerous challenges development efficient, targeted, safe delivery systems that can avoid siRNA degradation reduce toxicity adverse effects chemotherapy medicine. Results In this paper, a highly efficient AS1411 aptamer modified, dsDNA MMP-2 cleavable peptide-fabricated gold nanocage vehicle, which could load doxorubicin hydrochloride...
Abstract Fresh sweat contains a diverse range of physiological indicators that can effectively reflect changes in the body. However, existing wearable detection systems face challenges efficiently collecting and detecting fresh real‐time. Additionally, they often lack necessary deformation capabilities, resulting discomfort for wearer. Here, fully elastic electrochemical system is developed integrates sweat‐collecting microfluidic chip, multi‐parameter sensor, micro‐heater, circuit board...
Abstract A kind of new modified computational fluid dynamics‐discrete element method (CFD‐DEM) was founded by combining CFD based on unstructured mesh and DEM. The turbulent dense gas–solid two phase flow the heat transfer in equipment with complex geometry can be simulated programs when k‐ε turbulence model multiway coupling among particles, walls gas were employed. CFD‐DEM that model, employed to simulate behaviors fluidized bed an immersed tube. microscale mechanism explored simulation...
The development of multifunctional nanoparticles for tumor theranostics has become a research hotspot.
The critical issue in nanoscale medicine delivery systems is the targeted efficiency to guarantee maximum accumulation of nanodrugs tumors exert better therapeutic action. In this study, we adopted an active and potent strategy based on mesenchymal stem cells (MSCs) certified with excellent tumor-tropism ability load ship MnO2@Ce6 nanoparticles into a tumor site. Notably, under premise negligible cellular toxicity MSCs, its considerable uptake by MSCs enabled nanoplatform (MnO2@Ce6-MSCs)...
Abstract The need for biosensing systems, which are capable of reliable and accurate detection physiological signals disease biomarkers along with biocompatible surface chemistry textures device–human interface, has driven the continuous search advanced sensing materials, strategies, device structures. Hydrogels hydrophilic polymers high water content thus akin to human tissues. They not only able act as polymeric matrices load functional materials bio‐signal transducing, but also...
Schematic illustration of the synthetic process Fe<sub>3</sub>O<sub>4</sub>@MnO<sub>2</sub>–Ce6/CSL and mechanism cellular uptake pH-/H<sub>2</sub>O<sub>2</sub>-triggered MRI/FL imaging CT/PDT combination treatment.