A5101873471- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- RNA Interference and Gene Delivery
- Sulfur Compounds in Biology
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- S100 Proteins and Annexins
- Cancer Mechanisms and Therapy
- melanin and skin pigmentation
- Underwater Acoustics Research
- Glutathione Transferases and Polymorphisms
- Melanoma and MAPK Pathways
- Bioactive Natural Diterpenoids Research
- Hippo pathway signaling and YAP/TAZ
- Extracellular vesicles in disease
- Kruppel-like factors research
- Metabolism and Genetic Disorders
- Nanoparticle-Based Drug Delivery
- Biomarkers in Disease Mechanisms
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
Huazhong University of Science and Technology
2013-2025
Wuhan Children's Hospital
2025
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Fudan University
2017-2023
Zhongshan Hospital
2017-2023
Shanghai Tenth People's Hospital
2021
Chinese University of Hong Kong
2020
Central South University
2020
Jining First People's Hospital
2020
Abstract Gastric cancer is the second leading cause of cancer-related death worldwide. RNA nanotechnology has recently emerged as an important field due to recent finding its high thermodynamic stability, favorable and distinctive in vivo attributes. Here we reported use thermostable three-way junction (3WJ) bacteriophage phi29 motor pRNA escort folic acid, a fluorescent image marker BRCAA1 siRNA for targeting, imaging, delivery, gene silencing regression gastric animal models. In vitro...
Abstract Hydrogen sulfide (H 2 S) is involved in cancer biological processes. However, there are several controversies concerning the role of H S development and progression. In this study, we found that growth migration hepatocellular carcinoma (HCC) cells were enhanced by 10–100 μM NaHS dose-dependently inhibited 600–1000 NaHS. The apoptotic levels reduced 25–100 but increased 400–1000 HCC cells. After treatment with 25–50 NaHS, protein p-EGFR, p-ERK, MMP-2, p-AKT increased, whereas PTEN...
Abstract Fibroblast growth factor receptor type 2 (FGFR2) has emerged as a key oncogenic that regulates gastric cancer (GC) progression, but the underlying mechanism of FGF–FGFR2 signaling pathway remains largely unknown. To identify potential molecular mechanisms FGFR2 in carcinogenesis and convey novel therapeutic strategy, we profiled FGFR alterations analyzed their clinical associations TCGA Hong Kong GC cohorts. We found overexpression cell lines primary tumors predicted poor survival...
PUF60 is a splicing variant of far upstream element binding protein 1-interacting repressor, which abnormally expressed in variety tumors and closely involved their progression. However, whether participates the occurrence development breast cancer remains unknown. Therefore, objective current study to explore effects mechanism progression cancer.PUF60 expression patterns tissues cells were determined by RT-PCR Western blotting. The relationship between patients' clinical features outcome...
Methionine sulfoxide reductase B1 (MsrB1) is a member of the selenoprotein family, which contributes to reduction methionine sulfoxides produced from reactive oxygen species (ROS) by redox processes in energy pathways. However, few studies have examined role MsrB1 human hepatocellular carcinoma (HCC). We observed that highly expressed HCC tissues and its expression correlated with prognoses patients after hepatectomy. In vitro, knockdown inhibits cell growth MTT EdU proliferation assay,...
Gene microarray and bioinformatic analysis showed that S100A8 was more abundant in the stroma surrounding tumor buddings (TBs) than primary cells colorectal carcinomas. Here, S100A8+ 419 carcinoma samples were stained by immunohistochemistry counted using Image-pro plus 6.0. TBs also biomarkers associated with epithelial–mesenchymal transition apoptosis assessed immunohistochemistry. We evaluated association between clinico-pathological variables as well survival. Migration invasion of...
Postoperative recurrence and metastasis are the major problems for current treatment of hepatocellular carcinomas (HCC) in clinic, including hepatectomy liver transplantation. Here, we report that arsentic-loaded nanoparticles (ALNPs) able to reduce invasion HCC cells vitro, and, more importantly, can strongly suppress vivo without adverse side effects. Compared free drug arsenic trioxide , ALNPs deliver into cancer efficiently, destroy structure microtubules aggregation microfilaments cell...
Renal cell carcinoma (RCC) is one of the most common malignant tumors in world. Vitexin (apigenin-8-C-D-glucopyranoside), a bioactive compound isolated from variety plants, has multiple protective effects on human health. The purpose this study was to investigate role vitexin RC and related molecular mechanism.Proliferation tested with Cell Counting Kit-8 Edu staining. Apoptosis studied flow cytometry. Immunofluorescent applied show LC3 spots. BALB/c nude mice bearing ACHN cells were...
Megakaryoblastic leukemia 1 (MKL1) was closely related to the pathogenesis of various human malignant cancers. MiR34a reported be cancer cell proliferation. Forkhead box protein 3 (FOXP3) a transcription factor that played different role in types. CDK6 involved cycle progression and upregulated several types The present study investigated effects MKL1/miR34a/FOXP3 axis on proliferation MGC803 gastric cells. Our results demonstrated overexpression MKL1 promoted MGC80-3 cells, directly binding...
The epithelial‑mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is an important underlying mechanism proliferative vitreoretinopathy (PVR). We previously found that L‑carnitine (β‑hydroxy‑γ‑N-trimethylammonium‑butyrate, LC) was significantly lower during the transforming growth factor‑β1 (TGF‑β1)‑induced EMT process in ARPE‑19 cells. present study assessed role LC RPE migration detected using a Transwell assay. Then, EMT‑related biomarkers were measured via western...
Sinigrin is a glucosinolate present in plants of the family Brassicaceae and has been considered for its anticancer potential. This study examines efficacy sinigrin on liver cancer caused by diethylnitrosamine (DEN) mice through analysis impact Nrf-2/HO-1, PI3K-Akt-mTOR, apoptotic pathways. Development was induced intraperitoneal injection at age 14 days with DEN (25 mg/kg) mice. Thereafter, orally administered doses 10 20 mg/kg body weight per day last 28 days. At end weeks, were sacrificed...
Pulmonary arterial hypertension (PAH) is a life-threatening disease without effective therapies. PAH associated with progressive increase in pulmonary vascular resistance and irreversible remodeling. SUMO1 (small ubiquitin-related modifier 1) can bind to target proteins lead protein SUMOylation, an important post-translational modification mechanism key role many diseases. However, the contribution of remains be fully characterized. In this study, we explored dedifferentiation smooth muscle...