A5100333126- RNA modifications and cancer
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Bacterial Genetics and Biotechnology
- Neuroscience and Neuropharmacology Research
- Advancements in Battery Materials
- Ion channel regulation and function
- Cancer-related gene regulation
- Advanced Battery Materials and Technologies
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Advanced Battery Technologies Research
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Connective tissue disorders research
- Bacteriophages and microbial interactions
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
- Genetic Associations and Epidemiology
- Virus-based gene therapy research
- DNA Repair Mechanisms
- Orbital Angular Momentum in Optics
Shanghai Advanced Research Institute
2024-2025
Chinese Academy of Sciences
2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Southwestern Medical Center
2023-2024
Rockefeller University
2014-2024
Howard Hughes Medical Institute
2014-2024
The University of Texas Southwestern Medical Center
2019-2024
Kunming Medical University
2015-2024
Beijing Institute of Technology
2022-2024
GIRK channels control spike frequency in atrial pacemaker cells and inhibitory potentials neurons. By directly responding to G proteins, PIP2 Na(+), is under the of multiple signaling pathways. In this study, mammalian GIRK2 channel has been purified reconstituted planar lipid membranes effects Gα, Gβγ, Na(+) analyzed. Gβγ must be present simultaneously activate GIRK2. not essential but modulates effect over physiological concentrations. Gαi1(GTPγS) no effect, whereas Gαi1(GDP) closes...
Accumulated evidence highlights the significance of crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) N6-methyladenosine (m6A). Herein, we conducted a widespread analysis regarding 5mC m6A regulators in hepatocellular carcinoma (HCC).Pan-cancer genomic was presented at transcriptomic, genomic, epigenetic, other multi-omics levels. Hub were summarized to define an module eigengene (EME), which reflected both pre- post-transcriptional...
We have fabricated a high-performance Sb anode, applied it for use in PIBs, and explored its reversible potassiation/depotassiation mechanism.
Microorganisms such as Pseudomonas putida play important roles in the mineralization of organic wastes and toxic compounds. To comprehensively accurately elucidate key processes nicotine degradation putida, we measured differential protein abundance levels with MS-based spectral counting P. S16 grown on or glycerol, a non-repressive carbon source. In silico analyses highlighted significant clustering proteins involved functional pathway degradation. The transcriptional regulation...
The level of fat deposition in carcass is a crucial factor influencing meat quality. Guangling Large-Tailed (GLT) and Small-Tailed Han (STH) sheep are important local Chinese fat-tailed breeds that show distinct patterns depots. To gain better understanding deposition, transcriptome profiles were determined by RNA-sequencing perirenal, subcutaneous, tail tissues from both the breeds. common highly expressed genes (co-genes) all six tissues, differentially (DE genes) between these two...
TRAAK is a membrane tension-activated K+ channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal antibodies in mice show localized exclusively nodes of Ranvier, the action potential propagating elements myelinated nerve fibers. Approximately 80 percent fibers throughout central and peripheral nervous system contain what likely an all-nodes or no-nodes per axon fashion. not observed at initial segment where potentials are first...
Atherosclerosis is a chronic inflammatory disease, in which macrophages determine the progression of atherosclerotic plaques. However, no studies have investigated how METTL3 (methyltransferase like 3) affects plaque formation vivo. Additionally, whether Braf mRNA modified by METTL3-dependent N6-methyladenosine (m6A) methylation remains unknown.We analyzed single-cell sequencing data plaques mice fed with high fat diet for different periods. Mettl3fl/fl Lyz2cre Apoe-/- and littermate control...
pH-dependent temperature- sensitive poly(ε-caprolactone)-graft-poly(2-(dimethylamino) ethyl methacrylate) (PCL-g-PDMAEMA), a kind of degradable, amphiphilic, cationic copolymer, was synthesized. PCL-g-PDMAEMA self-assembled into core-shell nanoparticles with an ultralow critical association concentration at about 8.1 × 10−4 g L−1. It found that were able to simultaneously entrap hydrophobic paclitaxel and load DNA. Hydrophobic drug paclitaxel, loaded by NPs, could be released faster in...
G protein gated inward rectifier K+ (GIRK) channels open and thereby silence cellular electrical activity when inhibitory coupled receptors (GPCRs) are stimulated. Here we describe an assay to measure neuronal GIRK2 as a function of membrane-anchored concentration. Using this show that four Gβγ subunits bind cooperatively GIRK2, intracellular Na+ – which enters neurons during action potentials further amplifies opening mostly by increasing affinity. A amplification is characterized used...
Increasing evidence has shown that chemo-resistance is related to the process of epithelial-mesenchymal transition (EMT) and increased invasiveness by tongue squamous cell carcinoma (TSCC) cells. Long non-coding RNAs (lncRNAs) play pivotal roles in tumor metastasis progression. However, mechanisms lncRNAs cisplatin-resistance-induced EMT are not well understood. In this study, a chemotherapy-induced lncRNA 1 (CILA1) was discovered using microarrays functionally identified as regulator...
The pursuit of advanced battery chemistries with enhanced energy density necessitates the exploration new materials, a process intricately tied to synthesis science. Despite promise O3-type sodium oxygen anionic redox cathodes as high-capacity their development has been severely hindered by lack understanding regarding synthetic mechanisms. Here, we elucidate pivotal role atmospheric conditions, particularly content, in such materials synchronizing multiple operando characterization...
Nickel-rich layered cathode materials, such as LiNixMnyCo1-x-yO2 (NMC), are essential for high-energy-density lithium-ion batteries used in electric vehicles due to their higher specific capacities compared lower nickel-content analogs. However, these materials suffer from structural instability, which becomes increasingly severe the nickel content rises. Despite significant importance, intrinsic change mechanisms of nickel-rich cathodes, especially at practical cycling rates, remain...
Hfq is a bacterial post-transcriptional regulator. It facilitates base-pairing between sRNA and target mRNA. mediates DsrA-dependent translational activation of rpoS mRNA at low temperatures. encodes the stationary-phase σ factor S , which central regulator in general stress response. However, structural information on Hfq–DsrA interaction not yet available. Although reported to hydrolyze ATP, ATP-binding site still unknown. Here, we report ternary crystal complex structure Escherichia coli...