A5056983219- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Olfactory and Sensory Function Studies
- Cancer-related gene regulation
- Schizophrenia research and treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- HER2/EGFR in Cancer Research
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- RNA modifications and cancer
- Epilepsy research and treatment
- Coenzyme Q10 studies and effects
- Radiomics and Machine Learning in Medical Imaging
Central South University
2004-2024
Hunan Cancer Hospital
2004-2024
Dalian Medical University
2021-2024
Xinqiao Hospital
2023-2024
Army Medical University
2023-2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Qingdao University
2021
Qingdao Municipal Hospital
2021
Capital Medical University
2012-2016
To determine whether antibiotic treatment is a risk factor for immune-related adverse events (irAEs) across different patients with cancer receiving anti-PD-1/PD-L1 therapies.The retrospective analysis includes clinical information from 767 treated at Hunan Cancer Hospital 2017 to 2020. The pharmacovigilance data individual cases of 38,705 safety reports the US Food and Drug Administration Adverse Event Reporting System (FAERS) 2014 2020, 25,122 World Health Organization database VigiBase...
Abstract Background The protective effect of Coenzyme Q10 (CoQ10) on the cardiovascular system has been reported, however, whether it can promote early recovery cardiac function and alleviate remodeling after myocardial infarction (MI) remains to be elucidated. Whether CoQ10 may regulate macrophage-mediated pro-inflammatory response MI its potential mechanism are worth further exploration. Methods To determine baseline plasma levels by LC-MS/MS, healthy controls patients ( n = 11 each) with...
Patients with peripheral T-cell lymphomas (PTCL) in the relapsed or refractory (r/r) setting have only a limited number of therapies available, and prognosis is extremely poor. SHR2554 an oral inhibitor against EZH2, rational therapeutic target for lymphomas.
Conclusions: The olfactory and intranasal trigeminal systems are closely connected. With regard to event-related potential (ERP), patients with dysfunction (OD) showed longer latency lower amplitude, which indicated decreased sensitivity. Different age, etiology, status also affect sensitivity differently. Objective: OD is a common symptom in the rhinology clinic. ERP considered an important method evaluate chemosensitivity. aim of this study was investigate changes sense postviral (PVOD)...
Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis.There an increasing evidence that MCs and their mediators are participated in remodeling of tumor microenvironment facilitate growth, epithelial-to-mesenchymal transition (EMT) metastasis.Methods: The transwell was conducted to evaluate correlations between non-small cell lung cancer (NSCLC) vitro.The RNA interference β-catenin performed further explore signaling pathway.Lung adenocarcinoma...
<h3>Importance</h3> There is currently no standard treatment strategy for patients with advanced non–small cell lung cancer (NSCLC) without driver gene variation after failure of 2 or more lines chemotherapy. <h3>Objective</h3> To assess the efficacy and safety apatinib combined oral vinorelbine. <h3>Design, Setting, Participants</h3> This phase prospective nonrandomized clinical trial evaluating plus vinorelbine recruited from Hunan Cancer Center, Hunan, China, January 1, 2017, to November...
Background: The relationship between alcohol consumption and Alzheimer’s disease (AD) pathology is unclear. Amyloid-β (Aβ) tau biomarkers in cerebrospinal fluid (CSF) have been proven valuable establishing prognosis pre-clinical AD. Objective: We sought to examine the associations CSF AD cognitive intact subjects. Methods: A total of 806 cognitively participants who had measurements Aβ, pTau, Tau proteins drinking characteristics were included from Chinese Biomarker Lifestyle (CABLE) study....
To explore the potential of CT radiomics in detecting acquired T790M mutation and predicting prognosis patients with advanced lung adenocarcinoma progression after first- or second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy.Contrast-enhanced thoracic was collected from 250 (with mutation, n = 146, without 104) on TKIs. Radiomic features were extracted each volume interest. The maximum relevance minimum redundancy least absolute shrinkage...
Conclusions: This hospital-based study found a gender differences in Chinese subjects with post-viral olfactory disorder (PVOD). Women appear to face higher susceptibility PVOD, finding that appears be magnified age and duration of loss.Objectives: PVOD is one the most common reasons for acquired dysfunction, but there little data populations. We analyzed order determine demographic risk factors clinical features this major population group.Methods: Data from 143 consecutive 117 other...
8572 Background: Taletrectinib (AB-106 / DS-6051b) is a next-generation, potent, CNS- penetrant, selective ROS1 tyrosine kinase inhibitor. The ongoing TRUST study (NCT04395677) multicenter, open-label, single-arm, Phase 2 of taletrectinib in Chinese ROS1-positive NSCLC patients who are TKI -naïve or crizotinib-pretreated. Here we present the updated efficacy and safety results study. Methods: eligible were enrolled into either TKI-naïve crizotinib-pretreated cohorts, treated with 600mg once...
Abstract Background Anomalous aortic origin of a coronary artery (AAOCA) is rare congenital anomaly with the potential to cause adverse cardiac events. However, there limited data on association between AAOCA and disease (CAD). Therefore, aim this study determine prevalence symptoms patients AAOCA, as well investigate correlation CAD in population referred for computed tomographic angiography (CTA). Methods results All consecutive who underwent CTA from 2010 2021 were included....
Abstract Background Omicron variant of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global threat to public health. Numerous asymptomatic and mild cases had been admitted in shelter hospitals quickly win fight against pandemic Shanghai. However, little is known about influencing factors for deterioration length stay (LOS) among these non-severe cases. Methods This study included 12,555 with COVID-19 largest hospital Shanghai, aiming explore prognostic...