A5051884399- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Kruppel-like factors research
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Nanowire Synthesis and Applications
Jiangsu Province Hospital
2015-2025
Nanjing Medical University
2016-2025
First Affiliated Hospital of Chinese PLA General Hospital
2022
The University of Texas MD Anderson Cancer Center
2006-2021
Nanjing University
2008-2013
Vanderbilt University Medical Center
2013
University of Oxford
2013
Genomics (United Kingdom)
2013
Neurological Surgery
2013
Government of Jiangsu Province
2008
Abstract Background Long non-coding RNAs play an important role in tumorigenesis, hence, identification of cancer-associated lncRNAs and investigation their biological functions molecular mechanisms are for understanding the development progression cancer. Recently, downregulation lncRNA MEG3 has been observed various human cancers. However, its non-small cell lung cancer (NSCLC) is unknown. The aim this study was to examine expression pattern NSCLC evaluate clinical significance tumor...
HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin organization promote tumor progression. However, little known about roles of this gene in development chemoresistance phenotype lung adenocarcinoma (LAD). Thus, we investigated involvement HOTAIR resistance LAD cells cisplatin. In study, show that expression was significantly upregulated cisplatin-resistant A549/DDP compared parental A549 cells....
Glioblastoma is refractory to conventional therapies. The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind acetylated lysine residues on histone tails. These recently emerged as important therapeutic targets in NUT midline carcinoma several types of hematopoietic cancers. In this study, the potential a novel BET inhibitor, JQ1, was assessed panel genetically heterogeneous glioblastoma samples.
Long noncoding RNAs (lncRNAs) have been identified as oncogenes or tumor suppressors that are involved in tumorigenesis and chemotherapy drug resistance. Maternally expressed gene 3 (MEG3) is an imprinted located at 14q32 encodes lncRNA, decreased MEG3 expression plays important role multiple cancers. However, its biological the development of chemoresistance phenotype human lung adenocarcinoma (LAD) unknown. This study aimed to observe LAD evaluate clinical significance resistance cells...
Background: Early multiple organ dysfunction syndrome appears to be facilitated with bacterial translocation in severe burn injury, yet the mechanisms of remain dispute. The aim this study was characterize potential role intestinal bifidobacteria pathogenesis gut-derived after burns and analyze effects bifidobacterial supplement on gut barrier function. Methods: Wistar rats were randomly divided into group (Burn, n = 60), sham (SB, 10) experiment 1, + saline (BS, 30), (BB, sham-burn (SS, 30)...
Abstract Background MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated several other cancers, its role non-small cell lung cancer (NSCLC) is unknown. The aim present study was to examine expression pattern NSCLC and clinical significance, as well biological tumor progression. Methods Expression analyzed 34 tissues five lines quantitative...
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in a variety of human cancers, including gastric cancer (GC). However, the function and mechanisms responsible for these molecules GC are not fully understood. In our previous study, we found that associated lncRNA HOXA11-AS is significantly upregulated tissues. Over-expressed promotes cells proliferation invasion through scaffolding chromatin modification factors PRC2, LSD1 DNMT1.HOXA11-AS expression levels was detected by...
BackgroundNSCLC (non-small-cell lung cancer) is the leading cause of cancer-related mortality worldwide. Both epigenetic and genetic changes contribute to initiation, development metastasis NSCLC. Recently, accumulating data have begun support notion that long noncoding RNAs (lncRNAs) function as new crucial regulators diverse biological processes, including proliferation, apoptosis metastasis, play roles in tumorigenesis. Nevertheless, further study warranted comprehensively determine...
Long non-coding RNAs are emerging as crucial regulators and prognostic markers in multiple cancers including non small cell lung cancer (NSCLC). In this study, we screened LINCO1133 a new candidate lncRNA which promotes NSCLC development progression, two independent datasets (GSE18842 GSE19804) from the Gene Expression Omnibus (GEO). LINC01133 is previously found to be over-expressed squamous (LSCC) knockdown its expression inhibits LSCC cells invasion. However, its' molecular mechanism...
Abstract Lung squamous cell carcinoma (LUSC) is a subtype of lung cancer for which precision therapy lacking. Chimeric antigen receptor T-cells (CAR-T) have the potential to eliminate cells by targeting specific antigens. However, tumor microenvironment (TME), characterized abnormal metabolism could inhibit CAR-T function. Therefore, aim this study was improve efficacy in solid TME investigating effects amino acid metabolism. We found that B7H3 highly expressed LUSC and developed DAP12-CAR-T...
Taletrectinib, a highly potent, CNS-active,
Long non-coding RNAs (lncRNAs) have emerged as major players in governing fundamental biological processes, and many of which are misregulated multiple cancers likely to play a functional role tumorigenesis. Therefore, identification cancer-associated lncRNAs investigation their functions molecular mechanisms important for understanding the development progression cancer. lncRNA associated with microvascular invasion HCC (lncRNA MVIH) was found be generally upregulated HCC. Moreover, MVIH...
Abstract Background Polo-like kinase 1 (PLK1) is highly expressed in many human cancers and regulates critical steps mitotic progression. Previously, we have reported that PLK1 was overexpressed non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms are not well understood. By using microRNA (miR) target prediction algorithms, identified miR-100 might potentially bind 3’-untranslated region of transcripts. The purpose this study to investigate roles its association with...
8502 Background: Sacituzumab Tirumotecan (SKB264/MK-2870)is a TROP2 ADC developed with novel linker to conjugate the payload, belotecan-derivative topoisomerase I inhibitor. The hydrolytically permits both extracellular pH-sensitive cleavage and intracellular enzymatic release membrane permeable payload enabling “bystander effect”. Here, we report initial results from phase II study of SKB264 combined KL-A167 in patients (pts) advanced NSCLC (OptiTROP-Lung01, NCT05351788). Methods: Pts...
Abstract Objectives To investigate the function and regulatory mechanism of Krüppel‐like factor 3 (KLF3) in lung cancer. Materials Methods KLF3 expression was analysed by qRT‐PCR Western blot assays. The proliferation, migration, invasion, cycle apoptosis were measured CCK‐8 EdU, wound‐healing Transwell, flow cytometry tumour growth detected nude mouse tumorigenesis assay. In addition, interaction between Sp1 accessed luciferase reporter, EMSA ChIP JAK2, STAT3, PI3K p‐AKT levels evaluated...
Abstract The THO complex (THOC) is ubiquitously involved in RNA modification and various THOC proteins have been reported to regulate tumor development. However, the role of THOC3 lung cancer remains unknown. In this study, we identified that was highly expressed squamous cell carcinoma (LUSC) negatively associated with prognosis. knockdown inhibited LUSC growth, migration, glycolysis. expression regulated by TRiC proteins, such as CCT8 CCT6A, which supported protein folding. Furthermore,...
Homeobox genes, a superfamily of evolutionarily conserved developmental function as critical master regulatory factors in controlling body plan specification and cell fate determination. Recently, substantial evidence indicates that the aberrant (HOX) genes also play key roles development cancers. Many reports have shown not only HOX gene expression is upregulated or downregulated many cancers but specific tends to differ based on tissue type. A5 (HOXA5) regulator morphogenesis...
Background: HER2 mutations are rare driver events in advanced NSCLC, with limited relief from current targeted therapies. This study aimed to characterize the molecular features of HER2-mutant NSCLC and evaluate clinical efficacy pyrotinib-based combination therapy as a first-line treatment, providing evidence for optimizing treatment strategies. Methods: patients diagnosed at Jiangsu Province People’s Hospital 2016 2024 were enrolled. HER2-positive cases screened by IHC/FISH further...