A5102817642- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Chinese history and philosophy
- Fatty Acid Research and Health
- Domain Adaptation and Few-Shot Learning
- Aortic Disease and Treatment Approaches
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- RNA Research and Splicing
- Pituitary Gland Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Neurological Disease Mechanisms and Treatments
- Central Venous Catheters and Hemodialysis
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Immunotherapy and Immune Responses
- Cardiovascular Health and Disease Prevention
- Infectious Aortic and Vascular Conditions
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Peking Union Medical College Hospital
2018-2025
Nanchang University
2016-2025
University of Hong Kong
2022-2025
Hong Kong University of Science and Technology
2023-2025
Tianjin Fire Research Institute
2022-2024
Tianjin Third Central Hospital
2022-2024
Tianjin Medical University
2016-2024
Tianjin International Joint Academy of Biomedicine
2022-2024
Shantou University
2016-2024
The identification of cancer-associated long non-coding RNAs and the investigation their molecular biological functions are important for understanding biology progression cancer. HOTAIR (HOX transcript antisense intergenic RNA) has been implicated in several cancers; however, its role non-small cell lung cancer (NSCLC) is unknown. aim present study was to examine expression pattern NSCLC evaluate clinical significance tumor progression.Expression analyzed 42 tissues four lines by...
Abstract Background MicroRNAs (miRNAs) are short, non-coding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Although miR-196a has been implicated several other cancers, its role non-small cell lung cancer (NSCLC) is unknown. The aim present study was to examine expression pattern NSCLC and clinical significance, as well biological tumor progression. Methods Expression analyzed 34 tissues five lines quantitative...
Long noncoding RNAs (lncRNAs) have emerged as critical regulators in a variety of human cancers, including gastric cancer (GC). However, the function and mechanisms responsible for these molecules GC are not fully understood. In our previous study, we found that associated lncRNA HOXA11-AS is significantly upregulated tissues. Over-expressed promotes cells proliferation invasion through scaffolding chromatin modification factors PRC2, LSD1 DNMT1.HOXA11-AS expression levels was detected by...
Human sperm cryopreservation in assisted reproductive technology is the only proven method that enables infertile men to father their own children. However, freezing and thawing reduces spermatozoon motility, viability, fertilizing ability. An association between dysfunctional spermatozoa due cryoinjury protein changes has not been established. We investigated through proteomic analysis differential characteristics freeze-thawed fresh samples obtained from nine normozoospermic donors....
Study Design. A retrospective study. Objective. The purpose of this study was to identify the independent risk factors for postoperative surgical site infection (SSI) after posterior lumbar spinal surgery based on perioperative analysis. Summary Background Data. SSI is one most common complications surgery. Previous studies have identified different However, were focused patient and procedure-related factors. Few reported correlation between laboratory tests SSI. Methods. carried out in a...
The purpose of this paper was to develop a machine learning algorithm with good performance in predicting bone metastasis (BM) non-small cell lung cancer (NSCLC) and establish simple web predictor based on the algorithm.Patients who diagnosed NSCLC between 2010 2018 Surveillance, Epidemiology End Results (SEER) database were involved. To increase extensibility research, data patients first at First Affiliated Hospital Nanchang University January 2007 December 2016 also included study....
Small extracellular vesicle (sEV) is an emerging source of potential biomarkers Alzheimer's disease (AD), but the role microRNAs (miRNAs) in sEV not well understood. In this study, we conducted a comprehensive analysis sEV-derived miRNAs AD using small RNA sequencing and coexpression network analysis. We examined total 158 samples, including 48 from patients, patients with mild cognitive impairment (MCI), 62 healthy controls. identified miRNA module (M1) that was strongly linked to neural...
Intensive care units (ICUs) in China primarily focus on active rescue efforts, and it is not common to provide palliative services within the ICU. As nurses play a primary role as caregivers for end-of-life patients ICU, necessary explore factors that impede or facilitate from their perspective. To barriers facilitators associated with implementing Chinese adult ICUs nurses' perspectives. This study utilized descriptive phenomenological research approach purposive sampling conduct...
The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated present study. DHA at 5-50 microg/ml successfully protected neurons against cytotoxicity, markedly increased cell viability, inhibited both nitric oxide (NO) production and calcium influx, activities antioxidant enzymes glutathione peroxidase (GSH-Px) reductase (GR). However, it did not alter levels (GSH) as compared to control. These results suggest...
Masked Autoencoder (MAE) has demonstrated superior performance on various vision tasks via randomly masking image patches and reconstruction. However, effective data augmentation strategies for MAE still remain open questions, different from those in contrastive learning that serve as the most important part. This paper studies prevailing mixing MAE. We first demonstrate naïve will contrast degenerate model due to increase of mutual information (MI). To address, we propose homologous...
Diffusion models have proven to be highly effective in generating high-quality images. However, adapting large pre-trained diffusion new domains remains an open challenge, which is critical for real-world applications. This paper proposes DiffFit, a parameter-efficient strategy fine-tune that enable fast adaptation domains. DiffFit embarrassingly simple only fine-tunes the bias term and newly-added scaling factors specific layers, yet resulting significant training speed-up reduced model...
// Chen-Chen Wei 1, * , Feng-Qi Nie Li-Li Jiang 2, Qin-Nan Chen 1 Zhen-Yao Xin Xuan Pan 3 Zhi-Li Liu 4 Bin-Bin Lu Zhao-Xia Wang Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, People's Republic China 2 Haimen Haimen, University Cancer Hospital Jiangsu Province, Institution The Jiangyin School Medicine, Southeast Jiangyin, These authors contributed equally to this work and should be regarded as joint first Correspondence to: Wang, email:...
This study explores the factors influencing death anxiety in patients with advanced cancer, and to investigate role of family function on anxiety, correlation between meaning life anxiety.Patients cancer who were hospitalized three institutions from November 2020 May 2021 recruited this cross-sectional study. The Chinese version Death Dying Distress Scale, Meaning Life Scale For Advanced Cancer Patients Family APGAR Index used assess function. Pain symptoms evaluated by Numeric Rating Scale....
Objective To explore the prevalence and risk factors of carotid artery (CA) stenosis among subclavian steal syndrome (SSS) patients to record their prognoses. Methods This observational study was retrospective. From January 2015 October 2022, 169 were diagnosed with SSS. Among them, 51 combined CA have surgical indications for both diseases. In this cohort, 24 treated (23 endovascular, 1 open), 12 (6 6 5 (1 open, 3 hybrid). The primary end point mortality, secondary points vessel re-stenosis...
Study Design. Subgroup analysis of a retrospective clinical and animal trial [Study different doses methylprednisolone on functional recovery spinal cord injury]. Objective. The aimed to investigate the efficacy low-dose regimens in promoting neural repair after SCI. Summary Background Data. Spinal injury (SCI) can result sensory, motor, autonomic nerve dysfunction, often leading disability or death. Methylprednisolone (MP) is preferred medication for treatment Low-dose regimen may be safer...
The present study is to evaluate the anxiolytic-like activities underlying ginsenoside Rg3 (GRg3). were induced by GRg3 (20 and 40 mg/kg, i.g), evidenced blocking decreased time entries in open arms elevated plus maze test reversing increased latency feed novelty-suppressed feeding test. In addition, levels on progesterone, allopregnanolone, serotonin (5-HT) prefrontal cortex hippocampus of chronic unpredictable stress (CUS) blocked i.g). Furthermore, corticotropin releasing hormone,...