Study Design. A retrospective study. Objective. The purpose of this study was to identify the independent risk factors for postoperative surgical site infection (SSI) after posterior lumbar spinal surgery based on perioperative analysis. Summary Background Data. SSI is one most common complications surgery. Previous studies have identified different However, were focused patient and procedure-related factors. Few reported correlation between laboratory tests SSI. Methods. carried out in a...

The purpose of this paper was to develop a machine learning algorithm with good performance in predicting bone metastasis (BM) non-small cell lung cancer (NSCLC) and establish simple web predictor based on the algorithm.Patients who diagnosed NSCLC between 2010 2018 Surveillance, Epidemiology End Results (SEER) database were involved. To increase extensibility research, data patients first at First Affiliated Hospital Nanchang University January 2007 December 2016 also included study....

Early detection of bone metastases is helpful for the treatment bladder cancer (BC). In this study, we investigated potential risk factors metastasis in newly diagnosed patients with BC. A total 902 BC between January 2000 and August 2016 were retrospectively reviewed. Of these patient, 50 (5.5%) identified metastasis. The serum levels alkaline phosphatase (ALP) calcium significantly higher than those without (P = 0.015 P<0.001). And concentration hemoglobin (HB) was significant lower...

The prognosis for renal cell carcinoma (RCC) is related to a high rate of metastasis, including 30% bone metastasis. In this study, we investigate the correlation between diverse clinical factors and metastases secondary from cancer (RCC), identify potential risk metastasis in newly diagnosed patients those who have already received treatment. data 372 with RCC were reviewed January 2000 August 2016. correlations age, gender, histopathologic types, alkaline phosphotase (ALP), CEA, AFP,...

MicroRNAs play an important role in the development and progression of Ewing's sarcoma (ES). Especially, expression let-7a has been reported to be significantly downregulated various cancers, can affect initiation maintenance tumor progression. However, relative effects on ES cells mechanisms are largely unknown. In this study, we identified underexpression human comparing with mesenchymal stem cells. Then, sought compensate for its loss through exogenous transfection mimic into cell lines...

Dysphagia is a common complication following anterior cervical spine surgery (ACSS). The incidences of dysphagia were variable and controversial. purpose this study was to determine the incidence early after ACSS with new scoring system, identify risk factors it. A prospective carried out patients who underwent from March 2014 August in our hospital included study. self-designed questionnaire delivered all first day fifth ACSS. Perioperative characteristics recorded, analyzed. total 104...

The transcript factor LHX2 is dysregulated in many cancers but its role osteosarcoma (OS) remains unclear.In this study, we confirm that up-regulated osteosarcoma, and silencing inhibits OS malignancy induces autophagy via mTOR signaling.We further demonstrate miR-129-5p negatively regulates suppresses the malignant phenotypes of OS.LHX2 overexpression could restore phenotypes.In conclusion, tumorigenesis regulated by miR-129-5p.Targeting miR-129-5p/LHX2/mTOR axis therefore represents a...

Thoracolumbar fracture is one of the most common fractures spine. And short-segment posterior fixation including fractured vertebra (SSPFI) usually used for surgical treatment it. However, outcomes SSPFI different types thoracolumbar are not clear, and whether it necessary to perform transpedicular bone grafting still controversial. This study was conducted determine clinical efficacy single-level fracture, make clear what kind need during surgery.Patients with undergoing surgery between...

Surgical intervention is an important option for treating spinal tuberculosis. Previous studies have reported different surgical procedures and bone grafts it. To our knowledge, few demonstrated the clinical results of using nonstructural autogenous graft in treatment The purpose this study to compare outcomes management lumbar tuberculosis by one-stage posterior debridement with grafting instrumentation versus anterior debridement, strut combined instrumentation. A total 58 consecutive...

Study Design. A retrospective study. Objective. The purpose of this study was to identify the rates and reasons, risk factors for unplanned reoperation lumbar spinal surgery during primary admission in terms a multicenter large patient population Summary Background Data. Unplanned is suggested be useful quality indicator surgery. However, patients underwent are not well established. Methods. This performed review all who at three institutions from January 2010 April 2015. Patients with...

Spinal tuberculosis is still prevalent in some developing countries. The purpose of this study to investigate the efficacy and safety one-stage posterior debridement, autogenous bone grafting, transpedicular screw fixation treating monosegmental thoracic lumbar adults. 37 patients were retrospectively reviewed study. data images, operative time blood loss volume, perioperative complications, achieve bony fusion, VAS score, neurologic function preoperatively postoperatively collected. mean...

Fatty acid synthase (FASN) is overexpressed in a variety of human cancers, and may be involved cancer metastasis. Hence, the strategies targeted on FASN have therapeutic potential for treating metastasis.The aim this study to investigate correlation expression with metastasis osteosarcoma.Human osteosarcoma cell lines U2-OS biopsy specimens were employed study. The protein was detected by IHC (immunohistochemistry) relationship analyzed. We performed cerulenin, an inhibitor FASN, inhibit...

Abstract This retrospective analysis aim to evaluate the potential risk factors for bone metastases (BM) in patients who were diagnosed with colorectal cancer (CRC). A total of 2790 CRC between January 2006 and December 2016 collected this study. All divided into 2 groups, BM no BM. The associations biomarkers (including age, gender, histopathological types, alkaline phosphatase (ALP), carcinoembryonic antigen (CEA), 125, so on), analyzed. analyses conducted by SPSS software (version 22.0,...

Accumulating studies showed that the expression of microRNAs (miRNAs) was dysregulated in osteosarcoma (OS). In this study, we sought to investigate effect let-7a on OS progression and its potential molecular mechanism.Quantitative real-time PCR (qRT-PCR) performed evaluate level Aurora-B (AURKB) tissues cells. The cells were treated with mimic, let7a inhibitor, negative mimic Lv-AURKB combined let-7a. ability cell proliferation, migration invasion measured using Cell Counting Kit-8 (CCK-8)...

<b>Background and Aim:</b> The strategies of targeting valosin-containing protein (VCP) may have therapeutic potential for treating cancer metastasis. In this study, we aim to investigate the correlation VCP expression in osteosarcoma (OS) tissues with pulmonary metastasis its possible molecular mechanism. <b>Materials Methods:</b> Expression 60 OS specimens was detected by immunohistochemistry (IHC) relationship analyzed. An artificial micro ribonucleic acid, VCP, performed silence U2-OS...