A5100732330- Thyroid Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Plant biochemistry and biosynthesis
- Cancer Cells and Metastasis
- Renal and Vascular Pathologies
- Chromatography in Natural Products
- Abdominal vascular conditions and treatments
- Advanced biosensing and bioanalysis techniques
- Aerogels and thermal insulation
- Thyroid and Parathyroid Surgery
- bioluminescence and chemiluminescence research
- Transition Metal Oxide Nanomaterials
- Conducting polymers and applications
- Cancer-related molecular mechanisms research
- Electrochemical Analysis and Applications
- Circular RNAs in diseases
- Analytical Chemistry and Chromatography
- Advanced Cellulose Research Studies
- Lipid Membrane Structure and Behavior
Wuhan Botanical Garden
2022-2025
Chinese Academy of Sciences
2025
Academy of Military Medical Sciences
2024
Kumamoto University
2022
Cancer Institute (WIA)
2022
Liaoning Cancer Hospital & Institute
2020-2022
Shaanxi University of Science and Technology
2009-2021
First Hospital of China Medical University
2005-2020
China Medical University
2005-2020
Tsinghua University
2019
Abstract Lotus, an economically significant aquatic crop within the genus Nelumbo (family naceae), includes two extant species nucifera and lutea . Renowned for its ornamental, culinary, medicinal value, lotus has seen notable advancements in genomics molecular biology, particularly reference genome sequencing assembly, bioactive compound biosynthetic pathways, mechanisms underlying key traits. Critical genes linked to horticultural characteristics, edible quality, properties, stress...
Bacterial cellulose/polyaniline (BC/PANI) nanocomposites display many potential applications in various fields. However, the conductivity and mechanical properties remain a challenge. Here, we developed novel method to prepare BC/PANI via chemical grafting of PANI onto epoxy modified BC (EBC), followed by polyacrylamide (PAM). For comparison, an situ sample was also prepared. The reaction between EBC retention on were confirmed FTIR, X-ray photoelectron spectroscopy, elemental analysis....
An unhealthy diet has been linked to increased incidence of chronic diseases. To investigate the relationship between and intestinal inflammation, mice in two experimental groups were fed on a high-fat or high-fructose diet, respectively. The result showed that defecation volume was significantly reduced compared with control group, levels pro-inflammatory cytokines (interleukin (IL)-1β IL-6) IgG serum significantly. In addition, inflammatory cell infiltration observed tissue, indicating can...
Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic radioresistance cancer cells limits therapeutic efficacy. We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase an attractive radiosensitizing target. Here we tested our hypothesis MLN4924, newly discovered investigational small molecule inhibitor NAE (NEDD8 Activating Enzyme) inactivates ligase, could act as novel agent in cells. Indeed, found MLN4924 effectively...
Inflammation and excessive proliferation of vascular smooth muscle cells (VSMCs) have key roles in various disorders, including restenosis, atherosclerosis pulmonary artery hypertension. However, the underlying mechanism remains unclear. The present study investigated role nuclear factor-κB (NF-κB) microRNA (miRNA) regulation VSMC under inflammatory conditions. It was demonstrated that miR‑17 stimulated VSMCs, enhanced cell cycle G1/S transition, increased levels proliferating antigen E2F1....
To investigate the clinical significance of ubiquitin-specific peptidase 19 (USP19) expression in gastric cancer (GC) compared with that normal tissues and cell lines.USP19 protein was analyzed 212 paired GC samples using immunohistochemical staining. Quantitative real-time PCR (qRT-PCR) Western blotting were used to detect level USP19 lines. The biological functions investigated by MTT assay, colony-forming wound healing assay gelatin zymography, apoptotic cells detected...
MicroRNAs play an important role in the development and progression of Ewing's sarcoma (ES). Especially, expression let-7a has been reported to be significantly downregulated various cancers, can affect initiation maintenance tumor progression. However, relative effects on ES cells mechanisms are largely unknown. In this study, we identified underexpression human comparing with mesenchymal stem cells. Then, sought compensate for its loss through exogenous transfection mimic into cell lines...
Lotus (Nelumbo nucifera) is a large aquatic plant that accumulates pharmacologically significant benzylisoquinoline alkaloids (BIAs). However, little known about their biosynthesis and regulation. Here, we show the two group III WRKY transcription factors (TFs), NnWRKY70a NnWRKY70b, positively regulate BIA in lotus. Both NnWRKY70s are jasmonic acid (JA) responsive, with expression profiles highly correlated to concentration pathway gene expression. A dual-luciferase assay showed could...
Many studies have revealed that microRNAs (miRNAs) play crucial roles in cancer development and progression. miRNA-30a (miR-30a), as a member of the miR-30 family, has been implicated various cancers. However, role miR-30a osteosarcoma remains unclear. In current study, we found was significantly downregulated tissues cell lines by using quantitative real-time polymerase chain reaction (qRT-PCR). addition, could inhibit growth, migration, invasion vitro. Furthermore, bioinformatics miRNA...
Primary thyroid lymphoma (PTL) is a rare malignant tumor; its pathogenesis closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics prognosis, but the specific reasons are not clear. Wnt5a representative protein non-canonical Wnt signaling. It plays an important role in many types tumors. This study explore changes receptor Ror2 development process significance their represent. We collected 22 patient...
Thyroid cancer is a common endocrine malignancy that has rapidly increased in global incidence. Inhibitor of growth 4 (ING4) been identified various types carcinoma; however, to the best our knowledge, no previous studies have investigated effects ING4 on thyroid cancer. In present study, SW579 cells were treated with recombinant protein, and results confirmed protein was able reduce rate proliferation, increase apoptosis inhibit mobility cells. These obtained using colony formation,...
A novel biosensor was prepared by using gold nanoparticles (AuNPs) signal amplification technology combined with liquid crystal to detect Cecropin B (CB). The surface of the substrate modified (3-aminopropyl)-triethoxysilane/N,N-dimethyl-N-octadecyl-(3-aminopropyl)-trimethoxysilyl chloride (APTES/DMOAP), glutaraldehyde (GA) as crosslinking, AuNPs and antibody (anti-CB) complex could be fixed on basal surface. CB anti-CB can bind make (LC) changes in a vertical orientation, so achieve purpose...
β-Elemene is commonly used as an anti-cancer agent in different types of cancers and its effects on glioblastoma have been studied through pathways. However, effect ring finger protein 135 (RNF135, OMIM 611358) (RNF135), which upregulated glioblastomas, has not yet explored. The current study focused the β-elemene human cell lines U251, U118, A172 U87 RNF13 5. A counting kit-8 assay wound healing utilized to test proliferation migration cells. Western blot quantitative real-time-polymerase...
Disruption of Wnt signaling often happens in tumorigenesis, but whether affects the early stages thyroid tumor, such as papillary carcinoma, is still a question, especially carcinoma without genomic RET/PTC mutation. In this study, we demonstrated important function K1 cells, which have no We found that cells enhanced comparison to normal cells. further require for growth and survival. Interestingly, identified enhancing E2F activity by either knockdown Rb or overexpression Cyclin D1 induces...
Primary thyroid lymphoma (PTL) is a rare malignant tumor; its pathogenesis closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics prognosis, but the specific reasons are not clear. Wnt5a representative protein non-canonical Wnt signaling. It plays an important role in many types tumors. This study explore changes receptor Ror2 development process significance their represent. We collected 22 patient...
Abstract Background: Hypoxia and inflammation tumor microenvironment (TME) play a crucial role in development progression. Although increased understanding of TME contributed to gastric cancer (GC) progression prognosis, the direct interaction between macrophage GC cells was not fully understood. Methods: normoxia microarrays GEO database analyzed. The peripheral blood mononuclear cell acquired from healthy volunteers. expression CXCL8 tissues lines detected by quantitative reverse...